Pregnancy: Nature's Experimental System

Scott, James S.

doi:10.1016/s0140-6736(76)90166-5

Cited by 25 publications

(3 citation statements)

References 33 publications

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“…2 In 1976 we discussed a case in which congenital heart block and maternal SLE were associated in relation to two others recorded, certain features suggesting that the association was not fortuitous. 4 Since then at least 30 cases have been reported and we have traced a further eight earlier case reports. It now appears that SLE is of major importance in the aetiology of CHB and that the relation extends to other connective-tissue United Kingdom, most of which were entered in the co-operative study of CHB organised by the Association of European Paediatric Cardiologists (AEPC).…”

Section: Introductionmentioning

confidence: 99%

Congenital heart block and maternal systemic lupus erythematosus.

Esscher¹,

Scott²

1979

BMJ

177

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Summary and conclusionsThe association between infants with congenital heart block (CHB) and the presence or later development of maternal systemic lupus erythematosus or other connective-tissue disease (CTD) was reviewed in 67 cases. In 24 cases CHB was diagnosed at or before birth. Of nine necropsies on affected infants, seven showed endomyocardial fibrosis. The results suggest that one in three mothers who deliver babies with CHB have or will develop CTD.The association is probably explained by placental transfer of a maternal antibody. Awareness of the association may lead to prevention of the birth of children with CHB and better neonatal care of affected children. IntroductionComplete congenital heart block (CHB) occurs in only about 1 in 20 000 pregnancies.1 About a quarter of the cases are associated with a heart malformation, but in the remainder the aetiology is unknown. Pregnancy in women with systemic lupus erythematosus (SLE) is also rare, occurring in about 1 in 1500.2 In 1976 we discussed a case in which congenital heart block and maternal SLE were associated in relation to two others recorded, certain features suggesting that the association was not fortuitous.4 Since then at least 30 cases have been reported and we have traced a further eight earlier case reports. It now appears that SLE is of major importance in the aetiology of

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Section: Introductionmentioning

confidence: 99%

Congenital heart block and maternal systemic lupus erythematosus.

Esscher¹,

Scott²

1979

BMJ

177

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“…We report here our finding of the presence of anti-Ro antibody in the serum of a mother with systemic lupus erythematosus (SLE) who had 2 infants with congenital heart block; these infants were the subjects of 2 of the original case reports described by Chameides et a1 in 1977 (2). One of us (NFR) observed this patient with SLE from 1969 until the patient's death in 1973.…”

Section: To the Editormentioning

confidence: 86%

Congenital heart block, systemic lupus erythematosus, and anti‐Ro antibodies

Parke

Rothfield

1985

Arthritis & Rheumatism

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“…In 1976 Scott discussed 3 cases of CCHB with maternal systemic lupus erythematosus (SLE) where certain features suggested that the association was not fortuitous (9) and in the following year McCue et al reported 22 children with CCHB among whom 14 had mothers with collagen disease (10).…”

Section: Putliogenesismentioning

confidence: 99%

Congenital Complete Heart Block

Esscher

Anderson³

et al. 1981

Acta Paediatrica

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Isolated congenital complete heart block has a heterogenous aetiology. In approximately one-third of the patients in the present material the mothers had symptoms or signs of connective tissue disease. The mortality is highest in the neonatal period, much lower during childhood and adolescence and increases slowly later in life. There are elderly patients who are completely asymptomatic but patients are also encountered with signs and symptoms of more or less severe myocardial damage. Stokes-Adams attacks may occur at any age. About 10% of patients below 15 years of age in this material and about 25% of those above 15 years (mean age 30 years) were paced. In the neonatal period the predominant indication for pacing was heart failure. It is difficult to make a prognosis in the individual patient. Apart from already known risk factors, a fixed or decreasing low ventricular rate neonatally and a prolonged QT time seem to be bad prognostic signs.

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Pregnancy: Nature's Experimental System

Cited by 25 publications

References 33 publications

Congenital heart block and maternal systemic lupus erythematosus.

Congenital heart block and maternal systemic lupus erythematosus.

Congenital heart block, systemic lupus erythematosus, and anti‐Ro antibodies

Congenital Complete Heart Block

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