Pregnancy Outcome among Women with Sickle Cell Disease in a Tertiary Health Institution in Abakaliki: A Retrospective Case-Control Study

Nwafor, Johnbosco Ifunanya; Ugoji, Darlington-Peter Chibuzor; Ibo, Chukwunenye Chukwu; Onwe, Blessing Idzuinya; Onuchukwu, Victor Jude Uchenna; Nobert, Chuka; Okwuchukwu, Vitus

doi:10.4236/ijcm.2019.108032

Cited by 8 publications

(11 citation statements)

References 14 publications

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“…This study reports that pregnancy complications are more frequent in HbSS than other genotypes. These findings are matched with the reports of several studies ( 6 , 15 , 57 , 58 ). The outcomes of pregnancy in the HbSS genotype were worse than HbAA and HbAS.…”

Section: Discussionsupporting

confidence: 92%

“…The decreased risk of adverse pregnancy outcome in women with HbSC is matched with the manner of the HbSC genotype. This genotype is frequently benign and may not be recognized until later in adult life ( 15 ). The results of a study in Brazil indicated that in women with SCD, the HbSS genotype was associated with a higher frequency of blood transfusion.…”

Section: Discussionmentioning

confidence: 99%

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Pregnancy in the Sickle Cell Disease and Fetomaternal Outcomes in Different Sickle cell Genotypes: A Systematic Review and Meta- Analysis

Aghamolaei¹,

Pormehr-Yabandeh²,

Hosseini³

et al. 2022

Ethiop J Health Sci

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BACKGROUND: Pregnancy is a major concern among women with the sickle cell disease (SCD), and it is associated with increased adverse outcomes. The aim of the present meta-analysis is to report the fetomaternal outcomes in different sickle cell genotypes.METHODS: In this systematic review and meta-analysis, a comprehensive search of databases and search engines such as PubMed, Scopus, Web of Science, ProQuest, Cochrane Library, Science Direct and Google Scholar were performed. Any observational studies that had compared at least one outcome such as maternal outcomes, fetal outcomes, and morbidity between two groups of pregnant women with different types of sickle cell genotypes and pregnant women without SCD were evaluated.RESULTS: A total number of 9,827 pregnant women with SCD were examined. The results showed that pregnancy in SCD increased the risk of adverse outcomes for the mothers (including postpartum hemorrhage, prematurity, pregnancy-induced hypertension, pre-eclampsia, eclampsia, cesarean section, lower segment cesareansection, maternal death), fetus (including live births, low birth weight, intrauterine growth restriction, APGAR score at 5 min <7, stillbirth, neonatal death, perinatal mortality, acute fetal distress, intrauterine fetal death) and morbidity among the SCD(severe anemia, urinary tract infection, blood transfusion, painful crisis, acute chest syndrome, vaso-occlusive crises).CONCLUSION: According to the results of this meta-analysis, pregnancy in the SCD is associated with an increased risk of maternal outcomes, fetal outcomes, and morbidity among SCD patients with different genotypes. Pregnancy in sickle cell hemoglobinopathies needs careful multidisciplinary management and cautious caring so as to decrease maternal and fetal morbidity and mortality.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Pregnancy in the Sickle Cell Disease and Fetomaternal Outcomes in Different Sickle cell Genotypes: A Systematic Review and Meta- Analysis

Aghamolaei¹,

Pormehr-Yabandeh²,

Hosseini³

et al. 2022

Ethiop J Health Sci

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“…21 Sickle cell disease-related maternal complications were present in 50% of cases, which in turn contributed to maternal mortality. Maximum cases were 23 There is a strong association between SCD and maternal pulmonary complications according to one meta-analysis. 24 To reduce the associated maternal morbidity and mortality in these patients, risk factors associated with pulmonary complications should be identified and treated preconceptionally.…”

Section: Discussionmentioning

confidence: 98%

Fetomaternal Outcomes among Patients with Sickle Cell Disease: A Retrospective Study

Chaudhary¹,

Pitre²

2023

Journal of South Asian Federation of Obstetrics and Gynaecology

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Introduction:We are presenting a study on pregnancy with sickle cell disease (SCD), which is the most common genetic disorder with high mortality and morbidity with varying severity. It is an increasing global health problem. Materials and methods: The cases were retrieved and a case-control study was done at GMERS Medical College and Hospital over a duration of 3 years from November 2019 to September 2022. General characteristics of 32 pregnancies and their fetomaternal complications were studied. A descriptive statistical analysis of the above-mentioned data was performed, and percentages were calculated. Results: Among 32 cases, 62.5% of cases were multigravida. Anemia (moderate and severe anemia) was the most common complication (71.87%). Hemolytic crisis was seen in 18.75%, and painful crises were seen in 6.25% cases, 9.37% of cases had acute chest syndrome. Complications such as urinary tract infection (UTI) were seen in 6.25%, preeclampsia in 34.37%, 56.25% had preterm deliveries, and history of miscarriage and stillbirth was seen in 34.37%. Intrauterine growth restriction (IUGR) was seen in 9.37%, neonatal death -3.12%, low birth weight -62.5%, fetal distress -12.50%, and intrauterine fetal death (IUFD) -6.25%. Maternal mortality was seen in 12.50% cases. Discussion: Because of physiological adaptations along with sickle cell crisis, maternal and fetal complications are more in SCD patients. Conclusion:The study will help understand the outcomes of pregnancy in SCD patients and will help for a better approach in treating these patients.

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“…Sickle cell disease (SCD) is the most common inherited disorder worldwide, being associated in pregnancy with a high risk of maternal and perinatal adverse outcomes, especially in low‐resource settings 1 . The incidence of SCD in low‐resource settings like Nigeria is up to 3% of the population, and unfortunately, Nigeria together with other sub‐Saharan countries like Cameroon has a high prevalence of SCD and reported rates of maternal mortality due to SCD exceeding 9% 2 . This is because the management of SCD in pregnancy is difficult in low‐resource settings where human, diagnostic, and therapeutic resources are less developed, limited, or unavailable 1 .…”

Section: Introductionmentioning

confidence: 99%

“… 1 The incidence of SCD in low‐resource settings like Nigeria is up to 3% of the population, and unfortunately, Nigeria together with other sub‐Saharan countries like Cameroon has a high prevalence of SCD and reported rates of maternal mortality due to SCD exceeding 9%. 2 This is because the management of SCD in pregnancy is difficult in low‐resource settings where human, diagnostic, and therapeutic resources are less developed, limited, or unavailable. 1 We are reporting a case of the preterm management of sickle cell crises in a twin pregnancy with poor antenatal care uptake in a primary healthcare facility devoid of a blood bank in Cameroon.…”

Section: Introductionmentioning

confidence: 99%

Preterm management of sickle cell crisis in a twin pregnancy with suboptimal antenatal care in a primary healthcare facility: A case report from Cameroon and literature review

Tih,

Takang,

Egbe

2023

Clinical Case Reports

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Key Clinical MessageTwin pregnancies in homozygous sickle cell patients are not only uncommon in our setting but are most often associated with adverse maternal–fetal outcomes especially in primary healthcare facilities where most of these cases initially present due to financial constraints, though lacking the necessary technical platform (including blood banks) to properly manage them.AbstractWe are reporting the case of the preterm management of sickle cell crises in a twin pregnancy with poor antenatal care uptake in a primary healthcare facility devoid of a blood bank in Cameroon. Ngungi Fely, a 21‐year‐old HbSS patient, of the Bakweri tribe G3P0020, blood group O rhesus positive, was admitted at our health facility at 33 3/7 weeks' gestation with twin pregnancy, clinical anemia (hemoglobin 3.3 g/dL), the pulse rate of 123 beats/min, the respiratory rate of 38 breaths per min, the temperature of 39.2°C, and altered state of consciousness. She has a history of two spontaneous abortions (16 and 18 weeks’ gestation) and has attended three antenatal care (ANC) visits (18, 24, and 28 weeks’ gestation) for the index pregnancy. She underwent cesarean delivery of two live‐born babies at 35 4/7 weeks' gestation and received 9 units of compatible blood (before, during, and after the cesarean) partly with the help of the “Blood Track Program” (which uses text messages to seek blood donors). The babies were referred to a secondary healthcare facility and the mother and babies' outcomes were uneventful. Sickle cell disease (SCD) in pregnancy is difficult to manage in primary care settings in Cameroon because of a poor technical platform. A multidisciplinary approach to the management of SCD in pregnancy is the mainstay in secondary and tertiary healthcare centers. The “Blood Track Program” is a good initiative that should be extended nationwide in Cameroon to reduce the burden of acquiring blood for transfusion, particularly in primary care centers devoid of blood banks.

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Pregnancy Outcome among Women with Sickle Cell Disease in a Tertiary Health Institution in Abakaliki: A Retrospective Case-Control Study

Cited by 8 publications

References 14 publications

Pregnancy in the Sickle Cell Disease and Fetomaternal Outcomes in Different Sickle cell Genotypes: A Systematic Review and Meta- Analysis

Pregnancy in the Sickle Cell Disease and Fetomaternal Outcomes in Different Sickle cell Genotypes: A Systematic Review and Meta- Analysis

Fetomaternal Outcomes among Patients with Sickle Cell Disease: A Retrospective Study

Preterm management of sickle cell crisis in a twin pregnancy with suboptimal antenatal care in a primary healthcare facility: A case report from Cameroon and literature review

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