Pregnancy Outcome in a Woman Exposed to Continuous Intrathecal Baclofen Infusion

Muñoz, Francisco Calderón; Marco, David García; Pérez, Alfonso Verdú; Camacho, Manuela Martínez

doi:10.1345/aph.18317a

Cited by 13 publications

(8 citation statements)

References 1 publication

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“…There have been case reports of successful use of this modality during pregnancy. Although no specific information is available about the potential teratogenicity of baclofen, children born of these pregnancies have not had abnormalities 50–52 . Our center treated one woman with ITB throughout her pregnancy, and she delivered an infant who had no problems.…”

Section: Itb Treatment and Outcomes In Adultsmentioning

confidence: 99%

Intrathecal baclofen use in adults with cerebral palsy

Krach

2009

Develop Med Child Neuro

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Intrathecal baclofen (ITB) is an effective treatment for both spasticity and dystonia in people with cerebral palsy (CP). Its use is becoming increasingly common. ITB is typically associated with fewer side effects than the oral form of the product, but there are risks related to the hardware needed for intrathecal delivery. Much of what has been reported in the literature about ITB is based on experience with children or groups of children and adults; few reports exclusively address its use in adults with CP. These reports indicate that muscle tone is consistently reduced, but there is some variability in functional outcomes. Few wellcontrolled studies have been done. Controversies remain concerning ITB, including whether a trial is needed before pump implantation, proper catheter tip placement, and programming options, as well as whether it contributes to the development or progression of scoliosis. These and other unanswered questions should be addressed in a systematic way.Spasticity is the most common abnormality of muscle tone associated with cerebral palsy (CP); it affects approximately 70% of those with CP.

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Section: Itb Treatment and Outcomes In Adultsmentioning

confidence: 99%

Intrathecal baclofen use in adults with cerebral palsy

Krach

2009

Develop Med Child Neuro

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“…Four separate case reports documenting 5 pregnancies have been previously reported, describing general pregnancy and infant outcomes after ITB therapy during pregnancy [1‐4]. Two of the cases reported a short course of ITB treatment during the third trimester, one documenting an ITB programmable pump implanted at 30 weeks' gestation and another, ITB administration for management of severe tetanus at 28 weeks' gestation for 3 weeks' duration.…”

Section: Discussionmentioning

confidence: 99%

“…Literature regarding intrathecal baclofen (ITB) therapy during pregnancy is sparse, especially that documenting outcomes of pregnancies in women exposed to ITB from the time of conception [1‐4]. Because of the lack of controlled, prospective studies of ITB administration in pregnancy, most practicing clinicians rely on previous experience in management of these unusual cases.…”

Section: Introductionmentioning

confidence: 99%

Intrathecal Baclofen Administration During Pregnancy: A Case Series and Focused Clinical Review

Morton

Rosenow

Wong

et al. 2009

PM&R

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“…There are five case reports on intrathecal baclofen therapy; three patients were treated throughout the whole pregnancy. All five newborns were healthy and did not show withdrawal symptoms (Roberts 2003, Munoz 2000. In two cases, 20-80 mg was taken orally throughout the whole pregnancy.…”

Section: Myotonolyticsmentioning

confidence: 97%