Pregnancy outcome in dairy and beef cattle after artificial insemination and treatment with seminal plasma or transforming growth factor beta-1

Odhiambo, John F.; Poole, Daniel; Hughes, L.; DeJarnette, J.M.; Inskeep, E. K.; Dailey, R. A.

doi:10.1016/j.theriogenology.2009.04.013

Cited by 43 publications

(42 citation statements)

References 25 publications

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“…The fact that embryo transfer results in high pregnancy rates also suggests that there is no absolute requirement for immunological signaling before the onset of conceptus elongation around d 13 to 15 of pregnancy. Furthermore, adding seminal plasma back at insemination in dairy and beef cattle did not improve pregnancy rates (Odhiambo et al, 2009). Pregnancy rates following embryo transfer are typically equal to or greater than those obtained by natural mating or the best AI programs.…”

Section: Mating-induced Immune Responsementioning

confidence: 94%

Symposium review: Immunological detection of the bovine conceptus during early pregnancy

Ott

2019

Journal of Dairy Science

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Section: Mating-induced Immune Responsementioning

confidence: 94%

Symposium review: Immunological detection of the bovine conceptus during early pregnancy

Ott

2019

Journal of Dairy Science

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“…Similarly, there was no significant effect of addition of TGFB to semen extender on total or live foetuses per litter, implantation rate or foetal survival in gilts (Rhodes et al 2006). There was also no effect of addition of seminal plasma to sperm used for AI on farrowing rates in pigs (Kirkwood et al 2008) or addition of seminal plasma or TGFB on pregnancy rates in beef and dairy cattle (Odhiambo et al 2009). In this last study, there was a tendency for TGFb to improve pregnancy rates of beef cattle when herd fertility was low, however.…”

Section: Angiogenesismentioning

confidence: 98%

“…There was also no effect of addition of seminal plasma to sperm used for AI on farrowing rates in pigs (Kirkwood et al. 2008) or addition of seminal plasma or TGFB on pregnancy rates in beef and dairy cattle (Odhiambo et al. 2009).…”

Section: Actions Of Cells and Molecules Of The Immune System That Promentioning

confidence: 99%

The Immunology of Early Pregnancy in Farm Animals

Hansen

2011

Reprod Domestic Animals

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Contents The mammalian conceptus undergoes development in the face of a functional immune system. This characteristic of viviparity creates opportunities and perils for the conceptus. In the period up to hatching from the zona pellucida, the conceptus appears immunologically inert with low expression of major histocompatibility complex (MHC) genes and little evidence for alterations in the function of maternal immune cells. The conceptus may benefit from cytokines produced by leucocytes resident in the reproductive tract or by other cells of the reproductive tract. One cytokine in particular, colony‐stimulating factor 2, can promote preimplantation development and cause changes in conceptus function that increase the likelihood that the conceptus develops to term. It is not clear whether activation of specific types of immune responses in early pregnancy can enhance the likelihood of pregnancy success. Semen deposition causes inflammation in the reproductive tract, but there is little evidence that this process is beneficial to pregnancy unless the uterus was exposed to a prior inflammatory event. Around the time of placentation, the period of immunological inertness of the conceptus is replaced by a period of immune activation caused by the expression of interferon genes in ruminants and pigs and MHC class I genes in invasive trophoblast of the horse. The large‐scale changes in the endometrium that occur as a result are likely to play an important role to ensure continued development of the conceptus. In contrast, other immune responses generated as a result of disease in the reproductive tract or other tissues (mastitis) can lead to death of the conceptus. Because of this hazard, as well as the possibility that cell‐mediated immune responses against the conceptus could occur, the immune system is regulated by both the mother and conceptus to reduce immune responsiveness during pregnancy.

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“…This cell-free, fluid fraction of the ejaculate is significantly diluted during semen preparation for use in AI programs, thus cows bred in this manner are only exposed to trace amount of SP. However, the relatively high pregnancy rates achieved in cattle following artificial insemination (AI) or embryo transfer (ET) suggest that maternal exposure to SP is not a critical component of the maternal immune response in cattle (Lima et al, 2009;Odhiambo et al, 2009). …”

Section: Response To Inseminationmentioning

confidence: 99%

Embryo maternal immune interactions in cattle

Fair¹

2016

Anim Reprod

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Mammalian embryo implantation requires the priming of the maternal immune system, but, not the provocation. There are many examples of conditions where a disturbed or aberrant immune profile during embryo implantation leads to pregnancy loss. However, these studies are primarily associated with human and mouse species; data is generally limited for cattle and livestock. Most available information centres on the endometrial response to interferon tau (IFNT), a type I antiviral cytokine, which is the maternal recognition factor for cattle and sheep. Interferon tau secretion by the embryo and detection by the dam is critical to corpus luteum (CL) maintenance and pregnancy retention. However, the large volume of bovine endometrial and conceptual transcriptomic data highlights a broader more integral role of the maternal immune system in the establishment of pregnancy in cattle. When taken together with available immunohistochemistry and flow cytometry data from livestock, mouse, and human, a profile of immune cell involvement from ovulation to conception and placentation emerges. The key events of pregnancy establishment in cattle and the involvement of the maternal immune system will be discussed.

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Pregnancy outcome in dairy and beef cattle after artificial insemination and treatment with seminal plasma or transforming growth factor beta-1

Cited by 43 publications

References 25 publications

Symposium review: Immunological detection of the bovine conceptus during early pregnancy

Symposium review: Immunological detection of the bovine conceptus during early pregnancy

The Immunology of Early Pregnancy in Farm Animals

Embryo maternal immune interactions in cattle

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