Pregnancy Outcome in Gestational Diabetes Compared to Body Mass Index

Rudman, Senka Sabolović; Djaković, Ivka; Gall, Vesna; Djaković, Željko; Košec, Vesna

doi:10.20471/acc.2019.58.01.05

Cited by 7 publications

(7 citation statements)

References 14 publications

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“…In our study, FABP4 level was independent of GDM diagnosis and was associated with higher BMI in both the GDM and control groups. This finding is consonant with other studies that have associated FABP4 with obesity [26][27][28], as well as by the linkage of higher BMI values and GDM [31,32]. Interestingly, women with GDM and BMI < 25 showed the lowest FABP4 levels, even when compared to healthy controls.…”

Section: Discussionsupporting

confidence: 89%

FABP4 and I-FABP Levels in Pregnant Women Are Associated with Body Mass Index but Not Gestational Diabetes

Vorobjova,

Tagoma,

Talja

et al. 2022

Journal of Diabetes Research

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Objectives. Gestational diabetes mellitus (GDM) is glucose intolerance detected initially during pregnancy. GDM poses an increased risk for the development of diabetes later in life. Fatty acid-binding protein 4 (FABP4) is a regulator of lipid metabolism and is associated with obesity, insulin resistance, and type 2 diabetes. Increased level of intestinal fatty acid-binding protein (I-FABP) may indicate impaired intestinal permeability, which may be an important contributor to the pathogenesis of type 1 diabetes and GDM. We aimed to compare FABP4 and I-FABP levels in pregnant women with GDM and in healthy pregnant controls, taking into consideration their prepregnancy body mass index (BMI), past exposures to enteroviruses (EV), and adipokine and cytokine levels, which have been shown to decrease insulin sensitivity. Material and Methods. Forty patients with GDM (median age 30.5) and 40 pregnant healthy controls (median age 31.1) were divided on the basis of their prepregnancy BMI into two groups: normal weight ( BMI < 25 , n = 20 ) and overweight ( BMI ≥ 25 , n = 20 ). FABP4 and I-FABP were measured from serum samples using commercial ELISA kits. Results. FABP4 and I-FABP levels did not differ between women with GDM and healthy pregnant controls ( p > 0.05 for both comparisons). However, both levels were associated with BMI ( p < 0.001 for both comparisons). Median I-FABP level was the highest in healthy controls with lower BMI (<25) ( p = 0.0009 ). FABP4 levels correlated with BMI and C-peptide values in both groups ( p < 0.001 ). Anti-EV antibody levels did not correlate with FABP4 or I-FABP levels. FABP4 and adiponectin levels were negatively correlated in controls ( r = − 0.61 , p = 0.0009 ), while I-FABP correlated positively with adiponectin ( r = 0.58 , p = 0.04 ) and resistin ( r = 0.67 , p = 0.04 ) levels in the GDM group. Conclusion. FABP4 and I-FABP levels were not dependent on the diagnosis of GDM, but rather on BMI. The correlation of I-FABP with adiponectin and resistin levels in women with GDM may suggests the importance of lipid metabolism in GDM-associated changes in intestinal permeability.

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Section: Discussionsupporting

confidence: 89%

FABP4 and I-FABP Levels in Pregnant Women Are Associated with Body Mass Index but Not Gestational Diabetes

Vorobjova,

Tagoma,

Talja

et al. 2022

Journal of Diabetes Research

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“…Pre-pregnancy overweight and obesity increases the probability of obstetric complications; despite the developed molecular analysis techniques, the pathogenesis of these phenomena is still not clear [ 116 ]. It seems very likely that the maternal intestinal microflora may be of great importance in this respect.…”

Section: Overweight Obesity and Excessive Weight Gain In Pregnancymentioning

confidence: 99%

Changes in the Gut Microbiome and Pathologies in Pregnancy

GORCZYCA

Obuchowska

Kimber-Trojnar

et al. 2022

IJERPH

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Pregnancy is a special period in a woman’s life when her organism undergoes multiple physiological changes so that the fetus has optimal conditions for growth and development. These include modifications in the composition of the microbiome that occur between the first and third trimesters of pregnancy. There is an increase in Akkermansia, Bifidobacterium, and Firmicutes, which have been associated with an increase in the need for energy storage. The growth in Proteobacteria and Actinobacteria levels has a protective effect on both the mother and the fetus via proinflammatory mechanisms. The aim of the study is to review the research on the relationship between the mother’s intestinal microbiome and gestational pathologies. Changes in the maternal gut microbiome is probably one of the mechanisms that occurs in various pregnancy diseases such as preeclampsia, fetal growth restriction, gestational diabetes mellitus, excessive gestational weight gain, and premature birth. For this reason, it seems vital to pay attention to certain interventions that can benefit the affected patients both in the short term, by preventing complications during pregnancy, and in the long term, as one of the mechanisms occurring in various gestational diseases is dysbiosis of the maternal intestinal flora.

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“…We reviewed the literature relevant to the assessment of fetal weight in the group of women with gestational diabetes (GDM), given the higher frequency of macrosomia accompanied with GDM. An increased number of complications arise during pregnancy burdened by GDM, and perinatal outcome is worse in women with GDM, especially if women were obese before pregnancy, as compared with women whose pregnancies were not burdened with GDM ( 1 ).…”

Section: Introductionmentioning

confidence: 99%

Ultrasound Diagnosis of Macrosomia among Women with Gestational Diabetes – Review of the Literature

Lovrić¹

2022

acc

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Pregnancies burdened with gestational diabetes (GDM) are more likely to end in birth of a macrosomic child, where the frequency of operative termination of pregnancy is more common, accompanied with more complications and injuries of both mother and child in comparison to the general population. The need to calculate fetal weight right before delivery has led to the development of numerous methods for greater estimation accuracy. We reviewed the related literature from 1980 to 2020, using the terms macrosomia, ultrasound assessment, gestational diabetes, and relevant articles were considered in preparation of this article. The most frequently used methods are based on two-dimensional ultrasound measurements of individual fetal biometric parameters and their combination in a mathematical regression model. Some methods involve the addition of other mother and child conditions to increase reliability of the method in recognizing macrosomia. In daily work, especially with pregnant women suffering from GDM, it is necessary to have reliable data on the estimated fetal weight before making the correct clinical decision on how to terminate the pregnancy. In this regard, we bring a review of the literature related to the assessment of fetal macrosomia, especially in women with GDM.

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Pregnancy Outcome in Gestational Diabetes Compared to Body Mass Index

Cited by 7 publications

References 14 publications

FABP4 and I-FABP Levels in Pregnant Women Are Associated with Body Mass Index but Not Gestational Diabetes

FABP4 and I-FABP Levels in Pregnant Women Are Associated with Body Mass Index but Not Gestational Diabetes

Changes in the Gut Microbiome and Pathologies in Pregnancy

Ultrasound Diagnosis of Macrosomia among Women with Gestational Diabetes – Review of the Literature

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