Pregnancy outcome in Turner syndrome: A French multi-center study after the 2009 guidelines

Cadoret, Florence; Parinaud, Jean; Bettiol, Célia; Pienkowski, Catherine; Létur, H.; Ohl, J.; Sentilhes, Loïc; Papaxanthos, Aline; Winer, Norbert; d’Argent, Emmanuelle Mathieu; Catteau-Jonard, Sophie; Chauleur, Céline; Biquard, F.; Hiéronimus, S.; Pimentel, Céline; Lous, Maëla Le; Fontaine, Nathalie; Chevreau, Julien; Parant, Olivier

doi:10.1016/j.ejogrb.2018.08.005

Cited by 32 publications

(33 citation statements)

References 34 publications

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“…In France, a guideline for pregnant women with TS was established in 2009. 19 Cadoret et al 20 reported that the implementation rate of preconception evaluations for complications was 74% after the establishment of this guideline; this rate is higher than that in our results. Therefore, the development of a clinical guidelines for pregnant women with TS in Japan is needed for improving their pregnancy outcomes.…”

Section: Discussioncontrasting

confidence: 80%

“…Therefore, the development of a clinical guidelines for pregnant women with TS in Japan is needed for improving their pregnancy outcomes. On the other hand, Cadoret et al 20 also reported that, despite the development of this guideline, it is only partially adhered to, and the aortic diameter was unknown in 37% of pregnancy cases with donated oocytes. This report suggests that developing guidelines and ensuring that it is followed are very important for improving the pregnancy outcomes in women with TS.…”

Section: Discussionmentioning

confidence: 99%

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Current situation and outcomes of pregnancy in women with Turner syndrome in Japan

Obata

Tsuburai

Shindo

et al. 2020

J of Obstet and Gynaecol

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Aim Reports on pregnancy and delivery in women with Turner syndrome (TS) in Japan are limited to case reports, and the current situation remains unclear. Therefore, this study aimed to clarify the current situation of pregnancy and delivery in women with TS in Japan. Methods Our study comprised primary and secondary surveys and we included perinatal centers approved by the Ministry of Health, Labor and Welfare. Results A total of 24 cases from 19 facilities were reported, and we obtained individual information for 20 cases from 16 facilities. Of these 20 patients, 13 (65%) had become pregnant via oocyte donation. Three of these patients had received oocyte donation in Japan, while the other 10 had received donations in foreign countries. The other seven patients became pregnant with their own oocyte, with spontaneous menarche. Live babies were delivered by 18 patients, while an induced abortion was required at 18 weeks of gestation in one patient and an intrauterine fetal death from an unknown cause was detected at 38 weeks of gestation in another patient. Cesarean section was performed in 14 patients, with the most frequent indication being cephalopelvic disproportion. The rate of implementation of screening for complications related to TS was low, suggesting insufficient cooperation between facilities responsible for TS treatment, infertility and pregnancy and delivery management. Conclusion To improve pregnancy outcomes in women with TS, improved cooperation between facilities and laws regarding oocyte donation in Japan are needed.

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Section: Discussioncontrasting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Current situation and outcomes of pregnancy in women with Turner syndrome in Japan

Obata

Tsuburai

Shindo

et al. 2020

J of Obstet and Gynaecol

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“…In general, women at risk of pre‐eclampsia can be treated with 75 mg aspirin from 12 weeks of gestation until delivery (National Collaborating Centre for Women's and Children's Health (UK), ), which is currently also recommended treatment for women with Turner syndrome (Webber et al, ). In France, a survey of 103 women with Turner syndrome and 170 pregnancies performed after implementation of new guidelines showed that pregnancy outcome was much improved with reduced frequencies of hypertension, preeclampsia, and prematurity and morbidity with no maternal deaths (Cadoret et al, ), compared with a similar survey some years earlier (Chevalier et al, ); the need to improve was acknowledged.…”

Section: Fertility and Pregnancymentioning

confidence: 99%

Recognition and management of adults with Turner syndrome: From the transition of adolescence through the senior years

Lin

Prakash

Andersen

et al. 2019

American J of Med Genetics Pt A

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Turner syndrome is recognized now as a syndrome familiar not only to pediatricians and pediatric specialists, medical geneticists, adult endocrinologists, and cardiologists, but also increasingly to primary care providers, internal medicine specialists, obstetricians, and reproductive medicine specialists. In addition, the care of women with Turner syndrome may involve social services, and various educational and neuropsychologic therapies. This article focuses on the recognition and management of Turner syndrome

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“…Fourteen oocyte donation centers recruited 103 patients with TS (Cadoret et al, 2018). One hundred and seventy clinical pregnancies were followed, including 35 natural pregnancies and 130 obtained after oocyte donation.…”

Section: Identify High Risk Patients Of Cardiovascular Eventsmentioning

confidence: 99%

How can we make pregnancy safe for women with Turner syndrome?

Donadille¹,

Bernard²,

Christin-Maître

2019

American J of Med Genetics Pt C

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Pregnancy is a crucial issue in patients with Turner syndrome (TS). Although natural pregnancies have been reported in 4-7% of TS patients, most women will need assisted reproductive technologies (ART) with oocyte donation. The main issue is the maternal mortality rate that is higher than in the general population. It is related to cardiovascular anomalies and particularly aortic dissection. Turner syndrome, per se, is not a contraindication for pregnancy, but a multidisciplinary screening is mandatory before initiating a pregnancy. It includes repeated aortic diameters evaluation, blood pressure measurement and biological testing evaluating thyroid and liver functions, as well as blood glucose level. In order to make the pregnancy safe, contraindications of pregnancy should be respected and identification of high-risk patients for cardiovascular events should be performed. Hypertension and pre-eclampsia prevention may benefit from beta-blockers and aspirin, respectively. Collaborations between endocrinologists, cardiologists and obstetricians are mandatory during pregnancy and even in the post-partum period. Counseling the patients about the risks of pregnancy, screening them and spreading the international guidelines to physicians taking care of patients with TS are the three pillars of a safe pregnancy.

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Pregnancy outcome in Turner syndrome: A French multi-center study after the 2009 guidelines

Cited by 32 publications

References 34 publications

Current situation and outcomes of pregnancy in women with Turner syndrome in Japan

Current situation and outcomes of pregnancy in women with Turner syndrome in Japan

Recognition and management of adults with Turner syndrome: From the transition of adolescence through the senior years

How can we make pregnancy safe for women with Turner syndrome?

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