Pregnancy outcome in women with peritoneal, ovarian and rectovaginal endometriosis: a retrospective cohort study

Vercellini, Paolo; Parazzini, Fabio; Pietropaolo, Giuliana; Cipriani, Sonia; Frattaruolo, Maria Pina; Fedele, Luigi

doi:10.1111/j.1471-0528.2012.03466.x

Cited by 116 publications

(134 citation statements)

References 10 publications

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“…Vercellini et al [32] in his study did not detect any particular findings with regard to the incidence of hypertension, preeclampsia, preterm birth, and abruption placenta, but he found an incidence of 3.7 % of placenta previa in women with endometriosis, more than 10 times the figure of 0.3 % reported in the general population.…”

Section: Discussionmentioning

confidence: 78%

Delivery and pregnancy outcome in women with bowel resection for deep endometriosis: a retrospective cohort study

et al. 2015

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Endometriosis affects women in reproductive age and can involve bowel in 6-12 % of the patients. In case of bowel occlusion or deep pain, radical laparoscopic endometriosic surgery associated with bowel resection is recommended. The purpose of this study was to analyze the conception rate, the obstetric complications, and the pregnancy outcome. This is a retrospective study; we investigated 51 patients with deep endometriosis who underwent surgical treatment with bowel resection during the period between 2000 and 2007. Among the 30 patients who gave birth to at least one live child after surgery, we considered only the first pregnancy following bowel resection and we investigated the incidence of pregnancy disorders, the gestational age at delivery, the baby birth weight, and the complications related to the different ways of delivery. We compared the results with a control group of 93 patients with no previous abdominal surgery. The whole group of 51 patients tried to conceive after surgery, and 30 women had at least one pregnancy with the birth of an alive baby. Considering only the first pregnancies after surgery, 6 (20 %) experienced gestational hypertensive disorders, 3 (10 %) had placenta previa, 6 (20 %) had preterm birth (<37 weeks), and 1 patient (3.3 %) gestational diabetes. In this group, the average newborn weight was 3000±545 g. Compared with the control group, women with previous bowel resection for deep endometriosis had a higher risk of hypertensive disorders (p<0.05), placenta previa (p<0.05), and lower newborn weight (p<0.05), while the association with preterm birth and gestational diabetes was not statistically significant. These patients experience 12 vaginal deliveries (40 %) and 18 caesarean sections (60 %). Comparing with the caesarean rate in the control group (29.03 %), the incidence of caesarean section in the study population was substantially higher (p<0.01) with 33.3 % of the sections performed because of previous bowel surgery. No differences in severe complication rates were observed between vaginal and caesarean deliveries (ns). Complete removal of endometriosis with bowel segmental resection seems to improve the pregnancy rate, but in this group, there is an increased incidence of hypertensive disorders, placenta previa, and lower newborn weight. Despite the small number of patients, we do not observe more complications in the vaginal group than in the caesarean group, so we hypothesize the previous radical surgery should not influence the way of delivery.

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Section: Discussionmentioning

confidence: 78%

Delivery and pregnancy outcome in women with bowel resection for deep endometriosis: a retrospective cohort study

et al. 2015

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“…Безусловно, генитальный эндометриоз влияет на ре-продуктивную функцию женщин [9][10][11][12][13][14]. В 1999 г. G. Gregoriou и соавт.…”

Section: пролактин и его рецепторы в патогенезе нгэunclassified

The significance of prolactin in the pathogenesis of genital endometriosis and the possibilities of dopamine agonist therapy

Molotkov¹,

Yarmolinskaya²

2015

Ross. vestn. akush.-ginekol.

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“…39,40 Recommendation Studies on pregnancy and pregnancy outcomes in women with endometriosis need to be undertaken.…”

Section: Recommendationmentioning

confidence: 99%

Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France

D’Hooghe²,

et al. 2013

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Endometriosis, defined as estrogen-dependent lesions containing endometrial glands and stroma outside the uterus, is a chronic and often painful gynecological condition that affects 6% to 10% of reproductive age women. Endometriosis has estimated annual costs of US $12 419 per woman (approximately €9579), comprising one-third of the direct health care costs with two-thirds attributed to loss of productivity. Decreased quality of life is the most important predictor of direct health care and total costs. It has been estimated that there is a mean delay of 6.7 years between onset of symptoms and a surgical diagnosis of endometriosis, and each affected woman loses on average 10.8 hours of work weekly, mainly owing to reduced effectiveness while working. To encourage and facilitate research into this debilitating disease, a consensus workshop to define future directions for endometriosis research was held as part of the 11th World Congress on Endometriosis in September 2011 in Montpellier, France. The objective of this workshop was to review and update the endometriosis research priorities consensus statement developed following the 10th World Congress on Endometriosis in 2008. 1 A total of 56 recommendations for research have been developed, grouped under 6 subheadings: (1) diagnosis, (2) classification and prognosis, (3) clinical trials, treatment, and outcomes, (4) epidemiology, (5) pathophysiology, and (6) research policy. By producing this consensus international research priorities statement, it is the hope of the workshop participants that researchers will be encouraged to develop new interdisciplinary research proposals that will attract increased funding support for work on endometriosis.

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Pregnancy outcome in women with peritoneal, ovarian and rectovaginal endometriosis: a retrospective cohort study

Cited by 116 publications

References 10 publications

Delivery and pregnancy outcome in women with bowel resection for deep endometriosis: a retrospective cohort study

Delivery and pregnancy outcome in women with bowel resection for deep endometriosis: a retrospective cohort study

The significance of prolactin in the pathogenesis of genital endometriosis and the possibilities of dopamine agonist therapy

Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France

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