Pregnancy outcome in women with PCOS and in controls matched by age and weight

Haaková, L.; Cibula, David; Řežábek, K; Hill, Martin; Fanta, M.; Živný, J

doi:10.1093/humrep/deg289

Cited by 113 publications

(109 citation statements)

References 16 publications

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“…Most studies reporting an association between hypertension or pre-eclampsia and pregnancy in PCOS show mixed results. 28 In our study, none of the PCOS women developed gestational hypertension with or without metformin treatment. The study by Mikola showed that PCOS was not a significant predictor of preeclampsia compared with control pregnancies.…”

Section: Discussionmentioning

confidence: 45%

“…The link between PCOS and gestational diabetes was initially suggested by several retrospective series. [26][27][28] Women with PCOS who are insulin resistant are at high risk for the development of diabetes in pregnancy. In a large population based study, GDM has been reported to affect up to 18% of patients diagnosed with PCOS with an odds ratio of 2.4.…”

Section: Introductionmentioning

confidence: 99%

“…We compared the pregnancy outcomes of the women who became pregnant while taking metformin and remained on metformin throughout pregnancy versus www.asean-endocrinejournal.org Vol. 28 No. 1 May 2013 the pregnancy outcomes of the women who discontinued metformin at the time the pregnancy was confirmed.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Metformin on Pregnancy Outcome Among Filipino Women with Polycystic Ovary Syndrome

Uyking-Naranjo

Consencino

Mirasol

et al. 2013

JAFES

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Objective.To determine the effect of metformin on maternal and neonatal outcome among pregnant Filipino women with polycystic ovary syndrome (PCOS).Methodology.This is a retrospective cohort study of PCOS women who were on metformin treatment prior to achieving pregnancy. The women were divided into two groups: women who continued metformin during pregnancy and women who discontinued metformin at the time the pregnancy was confirmed. Determination of the effect of metformin on pregnancy outcomes were analyzed using chi-square test. Multivariate regression analysis was used to determine the factors related to spontaneous abortion.Result. A total of 101 women continued metformin during pregnancy while 60 women discontinued metformin. Women who continued metformin had lower rates of first trimester spontaneous abortion compared to those who discontinued metformin (5% versus 36.2%, p<0.001). There was no significant difference in gestational diabetes between those who continued and discontinued metformin during pregnancy (19.0% versus 32.6%, p=0.07). Logistic regression analysis showed that only metformin during pregnancy has a protective effect on abortion (OR=0.168; 95% CI 0.048,0.592; p=0.005). The differences in neonatal outcomes between the two groups did not achieve statistical significance.Conclusion. In Filipino women with PCOS, continuous use of metformin during pregnancy reduces the rate of first trimester spontaneous abortion.

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Section: Discussionmentioning

confidence: 45%

Section: Introductionmentioning

confidence: 99%

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The Effect of Metformin on Pregnancy Outcome Among Filipino Women with Polycystic Ovary Syndrome

Uyking-Naranjo

Consencino

Mirasol

et al. 2013

JAFES

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“…According to the Rotterdam consensus [3], PCOS is defined as the presence of two of the following criteria: hyperandrogenism, ovulatory dysfunction, and polycystic ovaries on ultrasound (12 or more follicles, 2-9 mm in diameter, and/ or increased ovarian volume >10 ml); disorders that mimic the clinical features of PCOS are excluded [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…These alterations can lead to glucose metabolism disorders and increased risk of developing gestational diabetes mellitus (GDM). Furthermore, pregnancy itself induces insulin resistance [1,2,4,5].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Gestational Diabetes Mellitus in Patients with Polycystic Ovary Syndrome

Julia¹,

Carlos²,

Ivonne³

et al. 2014

J Diabetes Metab

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Hyperandrogenism and Polycystic ovary syndrome: Effects in pregnancy and offspring development

Abruzzese

Silva

Velázquez

et al. 2022

WIREs Mechanisms of Disease

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Polycystic ovary syndrome (PCOS) is one of the major endocrine disorders affecting women of reproductive age. Its etiology remains unclear. It is suggested that environmental factors, and particularly the intrauterine environment, play key roles in PCOS development. Besides the role of androgens in PCOS pathogenesis, exposure to endocrine disruptors, as is Bisphenol A, could also contribute to its development. Although PCOS is considered one of the leading causes of ovarian infertility, many PCOS patients can get pregnant. Some of them by natural conception and others by assisted reproductive technique treatments. As hyperandrogenism (one of PCOS main features) affects ovarian and uterine functions, PCOS women, despite reaching pregnancy, could present high-risk pregnancies, including implantation failure, an increased risk of gestational diabetes, preeclampsia, and preterm birth. Moreover, hyperandrogenism may also be maintained in these women during pregnancy. Therefore, as an altered uterine milieu, including hormonal imbalance, could affect the developing organisms, monitoring these patients throughout pregnancy and their offspring development is highly relevant. The present review focuses on the impact of androgenism and PCOS on fertility issues and pregnancy-related outcomes and offspring development. The evidence suggests that the increased risk of pregnancy complications and adverse offspring outcomes of PCOS women would be due to the factors involved in the syndrome pathogenesis and the related co-morbidities. A better understanding of the involved mechanisms is still needed and could contribute to a better management of these women and their offspring.

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Pregnancy outcome in women with PCOS and in controls matched by age and weight

Abstract: When differences in age and weight between PCOS patients and controls are negligible, PCOS is not associated with a higher risk of pregnancy complications.

Cited by 113 publications

References 16 publications

The Effect of Metformin on Pregnancy Outcome Among Filipino Women with Polycystic Ovary Syndrome

The Effect of Metformin on Pregnancy Outcome Among Filipino Women with Polycystic Ovary Syndrome

Prevalence of Gestational Diabetes Mellitus in Patients with Polycystic Ovary Syndrome

Hyperandrogenism and Polycystic ovary syndrome: Effects in pregnancy and offspring development

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