Pregnancy outcome of hemoglobin H disease

Tantiweerawong, N.; Jaovisidha, Adithep; Ayudhya, Nathpong Israngura Na

doi:10.1016/j.ijgo.2005.04.012

Cited by 10 publications

(13 citation statements)

References 3 publications

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“…Because the available data have been scarce, relations between HbH disease and pregnancy outcomes have been inconclusive. Ong et al [8] reported that HbH disease probably had no adverse effect on pregnancy, but Tantiweerawong et al [9] found that HbH disease may adversely affect maternal and fetal health, causing low birth weight in particular.…”

Section: Discussionmentioning

confidence: 99%

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Outcomes of pregnancies affected by hemoglobin H disease

Tongsong

Srisupundit

Luewan

2008

Intl J Gynecology & Obste

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Section: Discussionmentioning

confidence: 99%

“…None of the few published studies [8,9] on the outcomes of pregnancies complicated by HbH disease are cohort or case‐control studies. The objective of the present study was to compare the maternal and fetal outcomes of pregnancies complicated by HbH disease with those of normal pregnancies.…”

Section: Introductionmentioning

confidence: 99%

Outcomes of pregnancies affected by hemoglobin H disease

Tongsong

Srisupundit

Luewan

2008

Intl J Gynecology & Obste

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“…Hydrop foetalis can be the outcome of pregnancy of mothers with Hb H disease,67–68 and in fact, according to a report on hydrop foetalis in Thailand by Taweevisit and Thorner (2008),69 3.8% were related to Hb H disease. Ong et al (1977)70 reported that Hb H disease probably had no adverse effect on pregnancy, although Tantiweerawong et al (2005)71 found that Hb H disease may adversely affect maternal and fetal health, causing in particular low birth weight.…”

Section: Delivery Outcomes Of Pregnancies and Breast-feedingmentioning

confidence: 99%

Pregnancy in Thalassemia

Origa¹,

Comitini²

2019

Mediterr J Hematol Infect Dis

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Therapeutic advances, including the availability of oral iron chelators and new non-invasive methods for early detection and treatment of iron overload, have significantly improved the life expectancy and quality of life of patients with thalassemia, with a consequent increase in their reproductive potential and desire to have children. Hundreds of pregnancies have been reported so far, highlighting that women carefully managed during preconception usually carry out a successful gestation and labour, both in case of spontaneous conception and use of assisted reproductive techniques. A multidisciplinary team including a cardiologist, an endocrinologist and a gynaecologist, with the supervision of an expert in beta-thalassemia should be involved. During pregnancy, a close follow-up of maternal disorders and of the baby's status is recommended. Haemoglobin should be maintained over 10 g/dL to to allow normal foetal growth. Chelators are not recommended during pregnancy; nevertheless, it may reasonable to consider restarting chelation therapy with desferrioxamine towards the end of the second trimester when the potential benefit outweighs the potential foetal risk. Women with non-transfusion-dependent thalassemia who have never previously been transfused or who have received only minimal transfusion therapy are at risk of severe alloimmune anaemia if blood transfusions are required during pregnancy. Since pregnancy increases the risk of thrombosis three-fold to four-fold and thalassemia is also a hypercoagulable state, the recommendation is to keep women who are at higher risk -such as those who are not regularly transfused and those splenectomised- on prophylaxis during pregnancy and during the postpartum period. Keywords:Pregnancy, Thalassemia major, Thalassemia intermedia, Haemoglobin H disease, Counselling

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“…15,16,20 Some investigators who evaluated pregnancy outcome of women with HbH disease found a higher rate of low birth weight. 13,21 However, it was unclear whether fetuses with HbH disease had a direct effect on low birth weight. Interestingly, we observed no significant difference in the rate of low birth weight among the four groups, but the rate achieved statistical difference between non-thalassemic women and thalassemic women whose fetuses had HbH disease.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy Outcomes in Women Affected by Fetal Alpha-thalassemia: A Case Control Study

Jin

Huang

et al. 2021

Preprint

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To evaluate the possible associations between fetal α-thalassemia and risk of adverse pregnancy outcomes using a provincial woman-child health service information database in China. This was a case control study (N=438,747) in which we compared all singleton pregnancies of women with or without the α-thalassemia trait from May 2016 to May 2020, and where women with the trait were further allocated to a normal fetal group, a group of fetuses with the α-thalassemia trait, and a fetal group with hemoglobin H (HbH) disease according to the results of fetal DNA analysis. With thalassemic women whose fetuses were normal as the reference, fetuses in the HbH disease group showed a higher increase in the odds of Apgar scores being <7 at 1 minute (adjusted odds ratio [aOR], 2.79; 1.03–7.59) and 5 minutes (aOR, 4.56; 1.07–19.40). With non-thalassemic women as the reference, these trends were more obvious (aOR, 4.83; 2.55–9.16; aOR, 6.24; 2.75–14.18, respectively); whereas the normal fetal group was more likely to be diagnosed with postpartum hemorrhage (aOR, 1.66; 1.10–2.50). In addition, fetal HbH disease and gestational age were two independent factors influencing low Apgar scores, and their combination reflected medium accuracy in Apgar predictions.

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Pregnancy outcome of hemoglobin H disease

Cited by 10 publications

References 3 publications

Outcomes of pregnancies affected by hemoglobin H disease

Outcomes of pregnancies affected by hemoglobin H disease

Pregnancy in Thalassemia

Pregnancy Outcomes in Women Affected by Fetal Alpha-thalassemia: A Case Control Study

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