Pregnancy Outcome of Multiparous Women Aged over 40 Years

Abstract

Objective. The aim of this study was to evaluate the effect of maternal age on prenatal and obstetric outcome in multiparaous women. Materials and Methods. A retrospective case control study was conducted, including women aged 40 years and over (study group, n = 97) who delivered at 20 week's gestation or beyond and women aged 20–29 years (control group, n = 97). Results. The mean age of women in the study group was 41.2 ± 1.7 years versus 25.4 ± 2.3 years in the control group. Advanced maternal age was associated with a significantly higher rate of hypertension, diabetes mellitus, fetal complication, and 5-minute Apgar scores <7 (P < 0.05). Caeserean section rate, incidence of placental abruption, preterm delivery, and neonatal intensive care unit admission were more common in the older group, but the differences were not statistically significant. Conclusions. Advanced maternal age is related to maternal and neonatal complications.

Complicações na gestação em mulheres com idade maior ou igual a 35 anos

“…en 30 and 34 (1) . The authors attribute the higher prevalence of chronic hypertension to vascular compromise with age, which can increase the susceptibility of those mothers to pregnancy-specific hypertension even if hypertension is not clinically recognised (1,11) .…”

“…As for parity, there was no significance for complications in pregnancy. According to some studies, however, multiparity is associated with increased maternal and neonatal risk (14) , and nulliparous women over 40 are at greater risk of complications, such as lower birth weight and shorter gestational age than those who have already had children (11) .…”

Pregnancy in advanced age and the risk of stroke in postmenopausal women: analysis of Women’s Health Initiative Study

“…T here is an increasing number of women with pregnancy and childbirth in the fourth decade of life for different reasons. [1][2][3] In United States between 2007 and 2011, birth rates have decreased for all women aged <35 years, unchanged for women aged 35e39 years, and increased for women aged 40e44 years. 4 Several studies have found increased rates of stillbirth, perinatal death, preterm birth, low birthweight, and maternal complications such as gestational diabetes mellitus and hypertension, preeclampsia, and need for interventions such as cesarean delivery among women !40 years.…”

Study of the neonatal outcomes in babies born to elderly mothers and young mothers

“…P value of APGAR <7 at 5 minutes was 0.032, which was statistically significant. 14 In the present study, 22 (10%) babies were SGA in the case group and only one (0.5%) baby was born SGA in the control group. The p value was <0.0001.…”

“…Study done by Seda A and Gonca B in Turkey, also found that NICU admission was more frequent in babies born to older women although the difference was not statistically significant. 14 Among 71 (30%) cases who had NICU admission, 20 (8%) cases had significant events in NICU, which included sepsis, jaundice, RDS, convulsions and death. Out of 39 (17%) controls shifted to NICU, only 6 (3%) had significant events.…”