Pregnancy outcomes after preterm premature rupture of membranes: The Japan Environment and Children's Study

Abstract

Aim: To evaluate the pregnancy outcomes of preterm premature rupture of membranes (preterm PROM; PPROM) by gestational age. Methods: This cohort study analyzed data from the Japan Environment and Children's Study. Pregnancy outcomes were documented using descriptive statistics. Logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of complications. Results: Data were collected for 104 062 fetuses, and 99 776 were eligible for inclusion. The incidences of early (18-23 weeks) and late (24-36 weeks) PPROM were 0.1% (n = 102) and 1.2% (n = 1205), respectively. Of the 1307 cases, 66 (5.0%) resulted in miscarriage or stillbirth. Overall, 85.6% (1119/1307) resulted in preterm births, and 9.3% (122/1307) in term births. There was a higher incidence of oligohydramnios (OR 6.82,

Exploratory study on the mechanism of necrotic effect of nourishing cells in the context of genital tract infection in premature rupture of membranes

“…Under the influence of pathogenic infections or danger signals, the innate and adaptive immune responses of the body are activated to recognize pathogen-associated molecular patterns. [ 32 ] As previously mentioned, the relative expression levels of Caspase-1, Caspase-3, NLRP3, and IL-1 proteins have been closely associated with preterm PROM. The findings from this study also indicate that there is no statistically significant difference in the relative expression levels of these proteins related to trophoblast cell apoptosis between preterm and full-term patients within the PROM group.…”