Pregnancy outcomes and contraceptive use in patients with systemic lupus Erythematosus, rheumatoid arthritis and women without a chronic illness: a comparative study

Galappatthy, Priyadarshani; Jayasinghe, Jayan D.; Paththinige, C. Sampath; Sheriff, Rezvi; Wijayaratne, L.S.

doi:10.1111/1756-185x.12996

Cited by 18 publications

(22 citation statements)

References 34 publications

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“…Nevertheless, methodological flaws were still existent. First, the sample sizes of some studies were small [15, 22]. The diagnosis criteria for APOs including GDM were obscure [14, 15, 22].…”

Section: Resultsmentioning

confidence: 99%

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Risk of gestational diabetes mellitus in systemic lupus erythematosus pregnancy: a systematic review and meta-analysis

Dong

Dai

Wang

et al. 2019

BMC Pregnancy Childbirth

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Background It is well established that the risks of insulin resistance and diabetes mellitus are elevated in systemic lupus erythematosus (SLE) patients. However, the relationship between SLE pregnancy and gestational diabetes mellitus (GDM) is still obscure. We perform the present systematic review and meta-analysis to determine the relationship between GDM and SLE pregnancy. Methods According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, relevant studies were carefully retrieved through PubMed, Cochrane library and Web of Science, China National Knowledge Infrastructure, Wanfang database and China Biology Medicine database from inception till 30 August 2018. GDM risk ratio (RR) of pregnant SLE patients versus controls was calculated to evaluate the association between GDM and SLE. Pooled RRs and 95% confidence intervals (CIs) were calculated using random effects model by R software. Results The literature retrieval identified 339 potential studies in total, and five studies containing 3432 pregnant participants with 248 GDM events were included finally. Pooled analysis found that the risk of GDM were not significant increased in SLE patients compared to controls (RR = 1.08, 95% CI = 0.49 to 2.41, Z = 0.19 and P = 0.848). Nevertheless, meta-regression identified that glucocorticoids use and anti-double stranded DNA antibodies positive of SLE patients were positively associated with the risk of GDM. Conclusions Our meta-analysis demonstrated that SLE pregnancy may not increase the risk of GDM, but the steroid use during pregnancy was associated with increased risk of GDM. Further large prospective and basic immunologic studies should be implemented for exploring the mechanism underlying glucocorticoids use and GDM. Electronic supplementary material The online version of this article (10.1186/s12884-019-2329-0) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

“…Present studies indicated that SLE pregnancy is associated with elevated risk of GDM [10]. However, studies also reported that the GDM risk of SLE patients was not significant increased [9, 14, 15]. Besides, whether there are specific risk factors influencing GDM incidence in SLE patients is also doubtful.…”

Section: Introductionmentioning

confidence: 99%

Risk of gestational diabetes mellitus in systemic lupus erythematosus pregnancy: a systematic review and meta-analysis

Dong

Dai

Wang

et al. 2019

BMC Pregnancy Childbirth

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“…Galappathy et al have reported an approximately 45% live birth rate in similar settings. 19 Appropriate contraceptive methods had been advised to all patients to avoid unwanted pregnancy, especially to prevent any possible deterioration of maternal condition due to the medical disorder.…”

Section: Discussionmentioning

confidence: 99%

Clinical presentation of autoimmune disorders in pregnancy

Singhal

Gupta

Prasad

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Autoimmune disorders have a significant impact over the health of an individual. This heterogenous group of disorders affects pregnancy in a multitude of ways. Pregnancies with autoimmune disorders are usually cared for by a multidisciplinary team of doctors.Methods: Pregnancies with autoimmune disorders were studied over a one-year period in one unit of a medical college teaching hospital set up. Obstetric and neonatal outcomes were studied.Results: Ten patients were studied. Average age was 29.9 years. Majority presented in early second trimester. Eight patients were ANA positive. Two patients had antiphospholipid antibody syndrome, for whom low molecular weight heparin was helpful. Hypothyroidism was seen in two patients. Bad obstetric history was seen in most patients. Successful neonatal outcome was seen in six patients. One patient had Evans syndrome. There were no maternal mortalities. There was one perinatal mortality.Conclusions: Autoimmune disorders in pregnancy when managed in a tertiary care centre with multidisciplinary approach can result in good obstetric and neonatal outcomes.

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“…Bir olgu doğumdan iki ay sonra hastalığın alevlenmesi ve kardiyak tutulum neticesinde kaybedildi. Daha önceki çalışmalarda hastalığın gebelik sırasında alevlenmesi için %13-33 arasında oranlar bildirilmiştir (21) . Oranların faklı olması çalışmalar arasında hastalık aktivasyonunun tanımındaki farklılıklardan ya da profilaktik kortikosteroid kullanılıp kullanılmaması ile ilgili olabilir.…”

Section: Gereç Ve Yöntemlerunclassified

Perinatal outcomes of 126 pregnancies with Sistemic lupus erythematosus

Özel¹,

Davutoğlu²,

Erenel³

et al. 2018

İstanbul Tıp Fakültesi Dergisi

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Pregnancy outcomes and contraceptive use in patients with systemic lupus Erythematosus, rheumatoid arthritis and women without a chronic illness: a comparative study

Abstract: More pregnancies occur in SLE than in RA after diagnosis of illness. Unplanned pregnancies and adverse pregnancy outcomes need to be addressed more in SLE than in RA or in WNCI.

Cited by 18 publications

References 34 publications

Risk of gestational diabetes mellitus in systemic lupus erythematosus pregnancy: a systematic review and meta-analysis

Risk of gestational diabetes mellitus in systemic lupus erythematosus pregnancy: a systematic review and meta-analysis

Clinical presentation of autoimmune disorders in pregnancy

Perinatal outcomes of 126 pregnancies with Sistemic lupus erythematosus

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