Pregnancy Outcomes in 30 Lung Transplant Recipients

Abstract

had same diagnosis). At last child follow-up, age 9.6±6.8 yrs, the 20 children were reported otherwise healthy and developing well. Conclusion: Successful pregnancy is possible after lung transplantation, though caution is advised as these are extremely high-risk pregnancies with high incidences of prematurity, low birthweight infants, and maternal mortality. Close surveillance of these recipients is warranted due to the negative impact of rejection during pregnancy on graft and recipient survival.

A single center Israeli experience in pregnancy post lung transplantation: Feasibility of successful two or more full‐term pregnancies in individual lung transplant recipients

“…This case series describes our single‐center experience with pregnancy after lung transplantation in Israel. Newborn outcomes in our cohort are significantly improved as compared to results reported in previously published case series 2–4,6 . Notably, we report the first series of two or more successful pregnancies in individual LTRs.…”

“…In terms of mortality, the same study reported a survival rate of 77% (23/30) with a maternal follow-up of 9.6 ± 6.8 years. 1,6 We observed two deaths in our cohort due to graft failure, translating into a survival rate of 75%, with one patient undergoing re-transplantation. These patients exceeded the median survival of 7.8 years following lung transplant, 12 before succumbing to graft failure at 8.5 and 14 years following the transplant, respectively.…”

“…Newborn outcomes in our cohort are significantly improved as compared to results reported in previously published case series. [2][3][4]6 Notably, we report the first series of two or more successful pregnancies in individual LTRs. While female LTRs of reproductive age are increasingly considering pregnancy, it is generally limited to a single birth, with the decision on a second child generally deferred or considered only in the context of surrogacy.…”

“…1 While various centers have summarized their local experience in post-lung transplant pregnancy outcomes, the available data on pregnancies in women after lung transplantation remains limited to less than 80 patients published in various case series. [2][3][4][5][6] Given such limited experience, lung transplant programs have been reluctant to advocate for pregnancy following transplantation. Furthermore, lack of data have hindered the promulgation of consensus guidelines, and only recently has the International Society of Heart and Lung Transplantation (ISHLT) published a consensus expert statement on reproductive health issues in thoracic transplantation.…”

“…Improved survival rates and advances in patient care post‐lung transplantation have led to an increased interest in pregnancy among female lung transplant recipients (LTRs) of reproductive age 1 . While various centers have summarized their local experience in post‐lung transplant pregnancy outcomes, the available data on pregnancies in women after lung transplantation remains limited to less than 80 patients published in various case series 2–6 . Given such limited experience, lung transplant programs have been reluctant to advocate for pregnancy following transplantation.…”