Pregnancy outcomes in women with gestational diabetes treated with metformin or insulin: a case–control study

Balani, Jyoti; Hyer, Steve; Rodin, D. A.; Shehata, Hassan

doi:10.1111/j.1464-5491.2009.02780.x

Cited by 127 publications

(124 citation statements)

References 18 publications

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“…Metformin treatment has been shown to be associated with reduced rates of PE, when used from early gestation in women with polycystic ovarian syndrome [31]. However, this finding is not universal and other studies in PCOS, type 2 diabetes mellitus and GDM have not reported the same association [32][33][34]. The MiG trial, from which these data are taken, did not find any difference in rates of PE in women allocated to metformin compared with those allocated to insulin for treatment of GDM, and the two groups did not differ in glycemic control attained [12].…”

Section: Discussioncontrasting

confidence: 47%

Predictors of Preeclampsia in Women in the Metformin in Gestational Diabetes(Mig) Study

Barrett

Nitert²,

McIntyre³

et al. 2014

J Diabetes Metab 2013

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Section: Discussioncontrasting

confidence: 47%

Predictors of Preeclampsia in Women in the Metformin in Gestational Diabetes(Mig) Study

Barrett

Nitert²,

McIntyre³

et al. 2014

J Diabetes Metab 2013

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“…The pregnancy outcomes in the women who were treated with metformin alone, demonstrated lesser incidence of prematurity, neonatal jaundice and admission to neonatal unit with an overall improvement in neonatal morbidity as compared to the women treated with insulin alone. There was no significant difference in the incidence of fetal macrosomia between the two groups of women [29].…”

Section: Ii) Metformin In Gestational Diabetesmentioning

confidence: 71%

“…In the light of the MiG findings, we conducted a case-control observational study comparing pregnancy outcomes in 100 women with GDM exclusively treated with metformin vs 100 with GDM exclusively treated with insulin and matched for age, weight, and ethnicity [29]. Both groups had similar baseline maternal risk factors.…”

Section: Ii) Metformin In Gestational Diabetesmentioning

confidence: 99%

Metformin in Pregnancy: Mechanisms and Clinical Applications

Hyer¹,

Balani²,

Shehata³

2018

Preprint

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Metformin use in pregnancy is increasing worldwide as randomised controlled trial (RCT) evidence is emerging demonstrating its safety and efficacy. The Metformin in Gestational Diabetes (MiG) RCT changed practice in many countries demonstrating that metformin had similar pregnancy outcomes to insulin therapy with less maternal weight gain and a high degree of patient acceptability. A multicentre RCT is currently assessing the addition of metformin to insulin in pregnant women with type 2 diabetes. RCT evidence is also available for the use of metformin for women with Polycystic Ovarian Syndrome and for non-diabetic women with obesity. No evidence of an increase in congenital malformations or miscarriages has been observed even when metformin is started before pregnancy and continued to term. Body composition and metabolic outcomes at two, seven and nine years have now been reported for the offspring of mothers treated in the MiG study. In this review, we will briefly discuss the action of metformin and then consider the evidence from the key clinical trials.

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“…Neste estudo, metade das gestantes aplicou 1000 mg diárias de metformina isoladamente e o outro grupo aplicou a terapia com insulina correspondente à idade, peso e etnia. Os resultados estatísticos novamente apontaram uma redução significativa no ganho de peso das gestantes que administraram metformina (p <0,001) (BALANI et al, 2009).…”

Section: Resultados Nas Terapias Metformina Versusunclassified

Os Efeitos Da Metformina Na Obesidade Da Gestante E No Peso Do Recém-Nascido

et al. 2017

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RESUMO:Quais são os resultados preponderantes com a administração do cloridrato de metformina no índice de massa corporal elevado da gestante e no peso do recém-nascido? Foi feita uma revisão sistemática da literatura selecionada entre os anos de 2000 a 2017 sobre a obesidade e os efeitos da terapia na gestação nas bases MEDLINE, LILA-CS, Embase e Cochrane. Analisou-se artigos disponíveis em meio eletrônico, publicados em português, espanhol e inglês. Dentre os 2.127 artigos inicialmente escolhidos, somente 29 estudos estavam dentro dos critérios estabelecidos. Os desfechos avaliados foram resultados da terapia metformina versus placebo, terapia metformina versus insulina e o impacto de diferentes dosagens de metformina utilizadas nas pesquisas. A medicação apresentou resultados relevantes na redução do peso da mãe, mas não o do recém-nascido. Novos estudos clínicos multicêntricos são necessários, bem como uma estratégia terapêutica inovadora quanto às dosagens do cloridrato de metformina durante os três trimestres da gravidez. PALAVRAS-CHAVE:Metformina; Gravidez; Obesidade; Recém-nascido. THE EFFECTS OF METFORMIN ON GESTATIONAL OBESIT Y AND NEWBORN WEIGHTABSTRACT: Which are the most predominant results with the administration of metformin hydrochloride in the high body mass index of the pregnant and in the newborn's weight? A systematic review of the literature choose from 2000 to 2017 on obesity and the effects of therapy on pregnancy in MEDLINE, LILACS, Embase and Cochrane databases was performed. Among the 2,127 papers initially chosen, only 29 studies presented the criteria established. The outcomes assessed were results of the metformin therapy versus placebo, metformin therapy versus insulin, and the impact of different dosages of metformin used in the researches. The drug presented relevant results in reducing the weight of the mother, but not the newborn. New multi-centre clinical studies are needed as well as an innovative therapeutic strategy regarding the dosages of metformin hydrochloride during the three quarters of pregnancy. KEY WORDS:Metformin; Pregnancy; Obesity; Newborn. INTRODUÇÃOO índice de obesidade na população mundial vem aumentando progressivamente. Em 2015 estimou-se 42 milhões de crianças Iramar Baptistella do Nascimento

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Pregnancy outcomes in women with gestational diabetes treated with metformin or insulin: a case–control study

Abstract: Women with GDM treated with metformin and with similar baseline risk factors for adverse pregnancy outcomes had less weight gain and improved neonatal outcomes compared with those treated with insulin. Diabet. Med. 26, 798-802 (2009).

Cited by 127 publications

References 18 publications

Predictors of Preeclampsia in Women in the Metformin in Gestational Diabetes(Mig) Study

Predictors of Preeclampsia in Women in the Metformin in Gestational Diabetes(Mig) Study

Metformin in Pregnancy: Mechanisms and Clinical Applications

Os Efeitos Da Metformina Na Obesidade Da Gestante E No Peso Do Recém-Nascido

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