Pregnancy outcomes in women with cardiothoracic transplants: A Systematic review and meta-analysis

Pregnancy Following Heart Transplantation: A Single Centre Case Series and Review of the Literature

“…In our case series, the median maternal age at pregnancy was 27 years (range 23-38 years). This is consistent with the mean maternal age at pregnancy in two recent publications of pregnancy outcomes after cardiac transplantation of 27 years (65.6 years) [10] and 28 years [11]. The median time from cardiac transplantation to pregnancy was 5 years (range 2-14 years) in our series which again was comparable to the published literature [10,11].…”

“…This is consistent with the mean maternal age at pregnancy in two recent publications of pregnancy outcomes after cardiac transplantation of 27 years (65.6 years) [10] and 28 years [11]. The median time from cardiac transplantation to pregnancy was 5 years (range 2-14 years) in our series which again was comparable to the published literature [10,11]. The most common reasons for cardiac transplantation in women who later became pregnant were congenital heart disease, viral myocarditis and idiopathic dilated cardiomyopathy [10,11].…”

“…The median time from cardiac transplantation to pregnancy was 5 years (range 2-14 years) in our series which again was comparable to the published literature [10,11]. The most common reasons for cardiac transplantation in women who later became pregnant were congenital heart disease, viral myocarditis and idiopathic dilated cardiomyopathy [10,11].…”

“…The recent systematic review and meta-analysis of observational studies in patients after thoracic transplant stated that mortality in pregnancy is very low, and significantly lower in patients with cardiac transplantation compared to lung transplantation [11]. Although mortality during pregnancy is low there is a significant risk of morbidity during pregnancy in cardiac transplant recipients.…”

“…The systematic review and meta-analysis did highlight an observed high rate of mortality for heart transplant recipients in the years following pregnancy. It is currently not clear whether this is a reflection of the shortened lifespan of heart transplant recipients generally or whether pregnancy itself contributes to increased mortality in the years following delivery [11]. These risks need to be carefully considered by the patient and weighed against their desire for pregnancy.…”