Pregnancy rate and outcome in Swedish women with Turner syndrome

Bryman, Inger; Sylvén, Lisskulla; Berntorp, Kerstin; Innala, Eva; Bergström, Ingrid; Hanson, Charles; Oxholm, Marianne; Landin‐Wilhelmsen, Kerstin

doi:10.1016/j.fertnstert.2010.12.039

Cited by 138 publications

(114 citation statements)

References 26 publications

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“…Italian data in 522 TS persons described 84 women with spontaneous pubertal development, whereas 30 women had regular menstrual cycles more than 9 years after menarche; among these 84 women, only three (3.6%) pregnancies were reported (18). However, spontaneous pregnancies are reported, also in 45,X persons (19,20). With the limited data available on births in TS persons and the well-known hypogonadal problems (21), the finding of 77 (46.1%) mothers in the 45,X/46,XX subgroup is striking but is backed up by recent Swedish data (21).…”

Section: Discussionmentioning

confidence: 99%

Socioeconomic parameters and mortality in Turner syndrome

Stochholm

Hjerrild

Mortensen

et al. 2012

European Journal of Endocrinology

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Background: Turner syndrome (TS) is characterized by hypogonadism, short adult height, increased morbidity and mortality, contrasted by self-reported normal quality of life and perception of health. Small studies have indicated a similar level of education compared with the background population. Aim: To study the socioeconomic profile in TS and the impact of these factors on mortality. Materials and methods: Register study using Danish nationwide registries. Nine hundred and seventynine TS females and 94 850 controls were included. Information concerning cohabitation, motherhoods, level of education (bachelor degree), income, retirement, and death were obtained. One hundred and three TS and 5989 controls died during the study period. For the socioeconomic parameters, median age at first relevant episode was calculated. Income was analyzed using conditional logistic regression and the other parameters using Cox regression. Results: In comparison with controls, TS had significantly fewer partnerships (hazard ratio (HR): 0.45), fewer motherhoods (HR: 0.18), and retired earlier (HR: 1.8). After the diagnosis of TS, the risk of retiring was increased. Educational attainment (HR: 1.0) as well as risk of unemployment was similar. Before the age of 30, low income was significantly more frequent; hereafter, it was similar to controls. Mortality was significantly increased (HR: 2.9) and slightly lower after adjustment for cohabitation and education (HR: 2.7). Conclusions: A divergent socioeconomic profile is apparent, with a reduced proportion of TS persons finding a partner and becoming mothers. The educational level was similar to controls. The increased mortality in TS was not materially affected after adjustment for cohabitation and education.

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Section: Discussionmentioning

confidence: 99%

Socioeconomic parameters and mortality in Turner syndrome

Stochholm

Hjerrild

Mortensen

et al. 2012

European Journal of Endocrinology

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“…The likelihood of cesarean section is also increased owing to maternal short stature, cardiovascular disease, hypertensive disorders, and intrauterine growth restriction (3,14). For the small percentage of women with Turner syndrome who conceive with their own oocytes, reports suggest that their pregnancies may be further complicated by an increased risk of spontaneous abortion and fetal chromosomal anomalies (7,25).…”

Section: Maternal and Fetal Morbidity And Mortalitymentioning

confidence: 99%

Fertility, pregnancy, and medical management of Turner syndrome in the reproductive years

Karnis¹

2012

Fertility and Sterility

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“…However, only patients with 45,X/46,XX mosaicisms, 46,XX karyotype with structural abnormality of the second X-chromosome spontaneously conceived live children. In Swedish women with TS, pregnancy occurred in 12% with spontaneous pregnancies occurring in 40% of these 12%, mainly in those with 45,X/46,XX mosaicisms [Bryman et al 2011]. Table 1 summarizes recent studies involving spontaneous pregnancies in Turner syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…The chance of dissection in pregnancy reaches 10% in some reports, particularly in the third trimester of the pregnancy and in the puerperium, and its main risk factors are hypertension, aortic coarctation, and bicuspid aortic valve [Bouchlariotou et al 2011]. Bryman et al [2011] reported aortic dissection during pregnancy in women with a postnatal diagnosis of TS, demonstrating that a delayed diagnosis may pose additional risk to pregnancies. Non-insulin dependent or gestational diabetes mellitus and dysregulation of thyroid disease are other causes of pregnancy complication in TS [Mortensen et al 2010].…”

Section: Discussionmentioning

confidence: 99%

Spontaneous procreation in Turner syndrome: report of two pregnancies in the same patient

Alves

Silva

2011

Systems Biology in Reproductive Medicine

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Spontaneous procreation in Turner syndrome (TS) is a rare condition, and repeated gestation is even rarer. We report two spontaneous and successful pregnancies (at the age of 25 and 28 y) in a patient with TS (karyotype: 45,X/47,XXX, in 30 metaphases). Births were by caesarean section due to fetal-pelvic disproportion. Both children, a boy and a girl, were born at full term, with normal physical exam and karyotype. Despite the elevated pregnancy risks associated with TS co-morbidities, this report presents two successful spontaneous pregnancies with normal children in a patient with TS diagnosis after her deliveries. Gynecologists and obstetricians should be aware of this possibility when evaluating women with unusual short stature or dysmorphic features in order to implement a more cautious prenatal care in those being diagnosed with TS.

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Pregnancy rate and outcome in Swedish women with Turner syndrome

Cited by 138 publications

References 26 publications

Socioeconomic parameters and mortality in Turner syndrome

Socioeconomic parameters and mortality in Turner syndrome

Fertility, pregnancy, and medical management of Turner syndrome in the reproductive years

Spontaneous procreation in Turner syndrome: report of two pregnancies in the same patient

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