Pregnancy-Related Mortality in the United States, 1998 to 2005

Berg, Cynthia J.; Callaghan, William M.; Syverson, Carla; Henderson, Zsakeba

doi:10.1097/aog.0b013e3181fdfb11

Cited by 677 publications

(338 citation statements)

References 12 publications

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“…10 Currently, the United States is ranked 60th in the world for maternal mortality. 11 According to a Centers for Disease Control and Prevention study, 12 the leading causes of maternal mortality are associated with chronic conditions that affect women of reproductive age, and common obstetric complications such as hemorrhage. Moreover, maternal mortality in the United States represents a small component of the larger emerging problem of maternal severe morbidities and near-miss mortality that increased by 75% between 1998e99 and 2008e09.…”

Section: Introductionmentioning

confidence: 99%

Levels of maternal care

Menard

Kilpatrick

Saade

et al. 2015

American Journal of Obstetrics and Gynecology

132

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Section: Introductionmentioning

confidence: 99%

Levels of maternal care

Menard

Kilpatrick

Saade

et al. 2015

American Journal of Obstetrics and Gynecology

132

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“…Although only a small proportion of deaths occur in high income settings, maternal mortality is an increasing concern because of an increase in risk factors such as obesity,3 advanced maternal age4 and births among migrants 5. These factors have been reflected in the increase in maternal deaths in the United States of America (USA) and in the Netherlands 6, 7…”

Section: Introductionmentioning

confidence: 99%

Factors associated with maternal mortality at advanced maternal age: a population‐based case–control study

McCall

Nair

Knight

2016

BJOG

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ObjectiveThis study aimed to examine the factors associated with maternal mortality among women aged ≥35 years.DesignUnmatched population based case–control study.SettingUnited Kingdom.PopulationBetween 2009 and 2012, 105 cases of maternal deaths aged ≥35 years were extracted from the surveillance database of the MBRRACE‐UK confidential enquiries into maternal deaths in the UK. In addition, 766 controls aged ≥35 years were identified from the UK Obstetric Surveillance System (2005–2012).MethodsRisk factors known to be associated with maternal mortality and morbidity and for which data were available were examined for their association with maternal mortality among women ≥35 years using logistic regression analysis.Main outcome measuresOdds ratios and 95% confidence intervals associated with maternal death.ResultsFive factors were found to be significantly associated with increased odds of death among women aged ≥35 years: smoking during pregnancy (adjusted odds ratio (aOR) 2.06, 95% CI 1.13–3.75), inadequate use of antenatal care (aOR 23.62, 95% CI 8.79–63.45), medical co‐morbidities (aOR 5.92, 95% CI 3.56–9.86) and previous pregnancy problems (aOR 2.06, 95% CI 1.23–3.45). The odds associated with death increased by 12% per year increase in age (aOR 1.12, 95% CI 1.02–1.22).ConclusionAge was associated with maternal mortality even after adjusting for other known risk factors. Importantly, this study showed an association between maternal mortality and smoking among women aged 35 years or older. It emphasises the importance of public health action to reduce smoking levels and address trends in rising maternal age.Tweetable abstractSmoking is a risk factor for maternal death for those aged over 35 years.

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“…However, most cases of PE and IUGR occur at or near term, including a substantial proportion of maternal morbidity and medically indicated late preterm births [48,49,50]. Consequently, late PE and IUGR and its early prediction/diagnosis represent a public healthcare priority.…”

Section: Prediction Of Complications Of Placental Diseasementioning

confidence: 99%

Update on the Pathophysiological Implications and Clinical Role of Angiogenic Factors in Pregnancy

2015

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Angiogenic markers are now being incorporated into clinical practice for the screening, diagnosing, and monitoring of preeclampsia. Pregnancy requires both vasculogenesis and angiogenesis in the fetal compartment and angiogenesis in the maternal compartment. Abnormal angiogenesis in the placenta determines impaired remodeling of the maternal spiral arteries and placental underperfusion that may ultimately lead to fetal growth restriction and maternal preeclampsia. The dysregulation of angiogenesis in the placenta and maternal-fetal circulation has emerged as one of the main pathophysiological features in the development of placental insufficiency and its clinical consequences. Abnormal angiogenesis has also been related to other obstetric and fetal conditions such as peripartum cardiomyopathy and fetal cardiac defects. This opens up new challenges for our understanding of angiogenic involvement in maternal cardiovascular function and fetal cardiac development, and it offers new clinical opportunities. This review summarizes the current knowledge of the pathophysiological implications and the clinical role of angiogenic factors in pregnancy.

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Pregnancy-Related Mortality in the United States, 1998 to 2005

Cited by 677 publications

References 12 publications

Levels of maternal care

Levels of maternal care

Factors associated with maternal mortality at advanced maternal age: a population‐based case–control study

Update on the Pathophysiological Implications and Clinical Role of Angiogenic Factors in Pregnancy

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