Pregnancy risk in female kidney and liver recipients: a retrospective comparative study

Abstract

Pregnancies after kidney transplantation are complicated with a higher prevalence of prematurity and worse neonatal prognosis, which depends mainly on the underlying condition.

Analysis of the Selected Biochemical Parameters of Liver and Kidney Function in Children of Mothers After Liver Transplantation

“…All of these drugs cross the placenta barrier. It is difficult to predict drug distribution in different tissues and their influence on the organs of the fetus [1,2].…”

The risk of obstetrical syndromes after solid organ transplantation

“…The high frequency of chronic hypertension in kidney recipients may explain the excess of severe obstetrical disorders in this population. In a retrospective study, Wielgos et al [15] compared maternal, neonatal and graft outcomes in pregnant women after kidney or liver transplantation. Complete data sets were collected in 38 pregnancies in 37 women.…”

Pregnancies in liver and kidney transplant recipients: a review of the current literature and recommendation

“…Outcome of pregnancies after kidney or liver transplantation according to the literature research (Table 4) Sample sizes of the studies included in the literature review varied between 19 and 692 pregnancies. Of those, 72 pregnancies were related to LTRs [6], and all others to KTRs. To maintain consistency when extracting data, Deshpande [3] used the number of pregnancies as the denominator for the analysis of pregnancy outcomes.…”

“…The mean gestational age and mean birth weight were higher for newborns of LTRs in comparison to the newborns of KTRs. Due to the higher pregnancy complications in KTRs, the mean gestational age was lower (35.6% [3], 35% [7] and 34.9% [6]) in comparison to LTRs (36.5% [4], 38% [7] and 37.5% [6]). Altogether, the rate of caesarean sections was lower for LTRs in comparison to KTRs.…”

“…In contrast to this comparison of the meta-analyses, there are currently two uni-centric studies summarizing the outcome of pregnancies in LTRs and KTRs in Poland [6] and in Germany [7]. In the latter, 115 pregnancies within a cohort of 37 LTRs and 34 KTRs were retrospectively analysed.…”