2019
DOI: 10.1007/s42000-019-00144-2
|View full text |Cite
|
Sign up to set email alerts
|

Pregnancy, thyroid, and the potential use of selenium

Abstract: The management of pregnant women is a major concern of health care around the world. There is growing evidence regarding the influence of selenium (Se) on pregnancy and fetus outcomes. However, due to as yet insufficient evidence, lack of measurable markers to assess the effect of Se supplementation on the human metabolism, and Se's narrow therapeutic index, the majority of experts and the current guidelines published by several scientific societies do not recommend the use of Se in pregnancy and in women of c… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
27
0
3

Year Published

2020
2020
2022
2022

Publication Types

Select...
8
1

Relationship

1
8

Authors

Journals

citations
Cited by 35 publications
(30 citation statements)
references
References 42 publications
0
27
0
3
Order By: Relevance
“…In summary, Se deficiency during pregnancy has been associated with a range of adverse effects on the fetus and mother and increased biomarkers of OS. While there is cogent evidence that SE supplementation may reduce occurrence of these adverse events as well as decrease the risk of AIT complications and prevent PP hypothyroidism, the current lack of clear cut-off levels for Se administration, which implicates the risk of overdose, at present tends to militate against Se supplementation in this setting [68]. Concerning patients with AIT, the current Guidelines do not recommend Se replacement during pregnancy [69], while there is a lack of randomized control trials (RCTs) to determine the safety and efficacy of Se supplementation in pregnancy at high risk for adverse events, including miscarriage, preeclampsia, preterm delivery, and fetal death.…”
Section: Se and Thyroid Autoimmunity During Pregnancymentioning
confidence: 99%
See 1 more Smart Citation
“…In summary, Se deficiency during pregnancy has been associated with a range of adverse effects on the fetus and mother and increased biomarkers of OS. While there is cogent evidence that SE supplementation may reduce occurrence of these adverse events as well as decrease the risk of AIT complications and prevent PP hypothyroidism, the current lack of clear cut-off levels for Se administration, which implicates the risk of overdose, at present tends to militate against Se supplementation in this setting [68]. Concerning patients with AIT, the current Guidelines do not recommend Se replacement during pregnancy [69], while there is a lack of randomized control trials (RCTs) to determine the safety and efficacy of Se supplementation in pregnancy at high risk for adverse events, including miscarriage, preeclampsia, preterm delivery, and fetal death.…”
Section: Se and Thyroid Autoimmunity During Pregnancymentioning
confidence: 99%
“…In summary, Se deficiency during pregnancy has been associated with a range of adverse effects on the fetus and mother and increased biomarkers of OS. While there is cogent evidence that SE supplementation may reduce occurrence of these adverse events as well as decrease the risk of AIT complications and prevent PP hypothyroidism, the current lack of clear cut-off levels for Se administration, which implicates the risk of overdose, at present tends to militate against Se supplementation in this setting [ 68 ].…”
Section: Introductionmentioning
confidence: 99%
“…Future double-blind placebo-controlled studies raising the issue of Se supplementation in pregnancy are warranted, especially in high-risk pregnancies in women from Se-depleted regions. Concomitant assessment of SePP as a marker of individual response for adjusting correct Se doses and the mutual interplay between different micronutrients may be relevant [55,56].…”
Section: Se Supplementation In Ait and Healthy Pregnant Womenmentioning
confidence: 99%
“…Selenium treatment led to a reduction in serum antithyroid antibody concentrations and prevented the development of PT [137]. However, these data are insufficient to recommend selenium supplementation during pregnancy and in women of childbearing age [147]. The possible beneficial effect of vitamin D in preventing the development of PT has also been highlighted, although the mechanism of this effect remains unclear [145].…”
Section: Antithyroid Antibodies: Effects On Procreation -Recommendations and Guidelinesmentioning
confidence: 99%