Pregnancy with mitochondrial disease complicated by threatened preterm labor and preeclampsia

Nakamura, Eishin; Ushijima, Junko; Samejima, Koki; Akashi, Keiko; Hotta, Daisuke; Kadowaki, Kanako; Horiuchi, Isao; Takagi, Kenjiro

doi:10.14390/jsshp.hrp2015-015

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…During pregnancy, women with MELAS syndrome or carrying the m3243A>G mutation are at high risk of obstetrical complications, such as diabetes and preeclampsia [5]. In their cohort study, De Laat et al showed a prevalence of 12% for preeclampsia in women carrying the m3243A>G mutation compared to 3.5% in the general population (a 7-fold higher risk) [2].…”

Section: Discussionmentioning

confidence: 99%

Maternal Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-Like Episodes Syndrome and Neonatal Magnesium Toxicity: A Case Report

Tinier¹,

Lorenzini²,

Joal³

et al. 2017

Gynecol Obstet

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Introduction: Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome is a progressive disorder associated with neurologic, cardiac, neuromuscular, hepatic, metabolic and gastrointestinal dysfunction, including potential anesthetic and obstetrical complications. Increased susceptibility to drugs in patient with MELAS syndrome can be due to drug-induced mitochondrial toxicity and/or decreased elimination. We present here a case of severe neonatal magnesium sulfate toxicity in the context of MELAS syndrome.

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Section: Discussionmentioning

confidence: 99%

Maternal Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-Like Episodes Syndrome and Neonatal Magnesium Toxicity: A Case Report

Tinier¹,

Lorenzini²,

Joal³

et al. 2017

Gynecol Obstet

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Fetal and obstetrics manifestations of mitochondrial diseases

Adelizzi,

Giri,

Di Donfrancesco

et al. 2024

J Transl Med

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During embryonic and neonatal development, mitochondria have essential effects on metabolic and energetic regulation, shaping cell fate decisions and leading to significant short- and long-term effects on embryonic and offspring health. Therefore, perturbation on mitochondrial function can have a pathological effect on pregnancy. Several shreds of evidence collected in preclinical models revealed that severe mitochondrial dysfunction is incompatible with life or leads to critical developmental defects, highlighting the importance of correct mitochondrial function during embryo-fetal development. The mechanism impairing the correct development is unknown and may include a dysfunctional metabolic switch in differentiating cells due to decreased ATP production or altered apoptotic signalling. Given the central role of mitochondria in embryonic and fetal development, the mitochondrial dysfunction typical of Mitochondrial Diseases (MDs) should, in principle, be detectable during pregnancy. However, little is known about the clinical manifestations of MDs in embryonic and fetal development. In this manuscript, we review preclinical and clinical evidence suggesting that MDs may affect fetal development and highlight the fetal and maternal outcomes that may provide a wake-up call for targeted genetic diagnosis.

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Pregnancy with mitochondrial disease complicated by threatened preterm labor and preeclampsia

Cited by 2 publications

References 7 publications

Maternal Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-Like Episodes Syndrome and Neonatal Magnesium Toxicity: A Case Report

Maternal Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-Like Episodes Syndrome and Neonatal Magnesium Toxicity: A Case Report

Fetal and obstetrics manifestations of mitochondrial diseases

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