Pregnancy with Wilson's disease complicated with thrombocytopenia: a case report

Acharya, Neema; Samal, Soumya; Sunilkumar,; Acharya, Sourya; Shukla, Samarth

doi:10.5455/2349-3933.ijam20140806

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…The incidence of liver disorder in pregnancy in our study is 2.8% which is comparable to study conducted by Dsouza, et al 2015 [3] was 3.3%. The peak age of incidence in our study was 21-30 years (86.56%) and majority of them were primigravida (59.70%), it is consistent with study by Acharya N et al [4] . Cholestasis of pregnancy 70.89% (n-94) was found to be the most common cause of liver dysfunction in our study followed by hypertensive disorders of pregnancy (14.17%) whereas study conducted by Dsouza et al 2015 [3] found that cholestasis of pregnancy was 54.9% cause of liver dysfunction in pregnancy.…”

Section: Discussionsupporting

confidence: 92%

Fetomaternal outcome in pregnancy induced liver disorders: A Hospital based prospective study

Rana¹,

Digra²,

Salgotra³

et al. 2021

Int. J. Clin. Obstet. Gynaecol.

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Pregnancy specific liver disorders are common, intrahepatic cholestasis is the commonest etiology. This was a prospective study, patients who were admitted to our department with pre-existing liver disease or those suspected to have liver dysfunction on the basis of clinical and laboratory data from AUGUST 2020 to July 2021 were included in our study. During the study period, there were 4638 deliveries in the hospital and 134 pregnant women were diagnosed to have liver disease. Chief complaint associated with liver disease found in this study was pruritus (70%) followed by gastrointestinal symptoms (16.22%), jaundice (5.97%) and asymptomatic (6%). Intrahepatic cholestasis of pregnancy was the most common cause of liver disease (70.14%) followed by hypertensive disorders/HELLP syndrome (14.17%), hyperemesis gravidarum (9.7o%), viral hepatitis (5.22%) and acute fatty liver of pregnancy (0.74%). Early diagnosis, proper maternal and fetal monitoring and timely intervention can prevent adverse maternal and fetal outcome.

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Section: Discussionsupporting

confidence: 92%

Fetomaternal outcome in pregnancy induced liver disorders: A Hospital based prospective study

Rana¹,

Digra²,

Salgotra³

et al. 2021

Int. J. Clin. Obstet. Gynaecol.

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“…AFLP is usually diagnosed by ruling out all other differential diagnoses and requires prompt intervention. Maternal and fetal prognosis has been transformed thanks to rapid diagnosis and timely delivery of the baby [2]. The diagnosis should be suspected in the face of the appearance of epigastric pain, vomiting, jaundice associated with an increase in transaminases.…”

Section: Introductionmentioning

confidence: 99%

Acute Fatty Liver of Pregnancy-a Rare but Potentially Catastrophic Cause of Jaundice in Pregnancy

Memon

Acharya

2021

JPRI

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A 27-year-old female primigravida at 36.2 weeks gestational age presented nausea, vomiting, and yellowish discoloration of the eyes. On investigation, she had deranged liver and kidney functions, and USG was suggestive of Coarse Echotexture of the Maternal liver. We diagnosed it as a case of Acute fatty liver of pregnancy followed by Early Caesarean section and intensive supportive management. Active monitoring of Haemodynamic status, Metabolic status, Coagulation profile, Renal, and CNS function resulted in a safe and healthy mother and child.

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Wilsons Disease Presenting as Acute Fulminant Hepatic Failure

Raja¹

2021

jemds

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Wilson’s disease (WD) is a genetic disorder characterised by mutations in copper metabolism. Adenosine triphosphate (ATPase) ATP7B gene is responsible for disturbance in copper metabolism that leads to accumulation of copper mainly in liver and also in extra hepatic organs (like brain, cornea, heart and kidney).1 Heavy metal accumulation in brain (mainly in basal ganglia) leads to neuropsychiatric manifestations.2 Kayser Fleischer (KF) ring is golden brown ring distributed along the periphery of cornea. It is due to abnormal deposition of copper in the Descemet’s membrane of cornea. Kayser Fleischer (KF) ring is a pathognomonic sign of Wilson’s disease. Fulminant hepatic failure can be the first presentation of WD. Patients presenting with fulminant Wilson’s disease (FWD) clinically present as acute liver failure with encephalopathy and coagulopathy. The mortality of patients is high and orthotropic liver transplantation is the only option, which has been shown effective in patients with Fulminant Wilson’s disease.3 We are report a case of a young male who presented as acute liver failure first time in life and later was diagnosed as FWD.

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Pregnancy with Wilson's disease complicated with thrombocytopenia: a case report

Cited by 3 publications

References 3 publications

Fetomaternal outcome in pregnancy induced liver disorders: A Hospital based prospective study

Fetomaternal outcome in pregnancy induced liver disorders: A Hospital based prospective study

Acute Fatty Liver of Pregnancy-a Rare but Potentially Catastrophic Cause of Jaundice in Pregnancy

Wilsons Disease Presenting as Acute Fulminant Hepatic Failure

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