This paper presents an innovative Internet of Things (IoT)-based smart emergency response system that aims to improve safety and efficiency across vehicles, homes and healthcare settings. The proposed system combines advanced sensors, communication technologies, and intelligent algorithms to provide a comprehensive solution for real-time monitoring and emergency management. The vehicle device is equipped with temperature, gas, flame, GPS, piezo, and accelerometer sensor and the system can detect accidents and hazardous conditions, automatically notifying emergency services and providing precise location data. For home security, it incorporates Flame Sensor, humidity sensor, DHT11, MQ-2 gas sensor, MQ-4 Gas Sensor, and MQ-135 gas sensor, and intrusion detection to ensure immediate alerts and response to potential threats. In healthcare, the proposed health device is equipped with temperature, humidity, stress levels, heart rate, oxygen saturation, and fetal heart rate sensor which can monitor vital signs and detect anomalies, triggering alerts for medical emergencies and facilitating timely intervention. The system utilizes a cloud-based platform to collect, analyze, and disseminate data, enabling seamless coordination between emergency responders such as ambulance for health and accident emergency, fire brigade for fire emergency and affected individuals. We have also developed a MySQL-PHP-Laravel based live dashboard and emergency response system where both the user and relevant stakeholder will have the access which could mitigate the emergency situation in the quickest amount of time without human intervention. By leveraging IoT capabilities, the smart emergency response system offers significant improvements in response times, accuracy, and overall effectiveness of emergency management. This integrated approach not only enhances individual safety but also contributes to broader public safety goals, showcasing the potential of IoT technologies in creating smarter, safer environments. Further development and field testing are anticipated to refine the system's functionality and expand its application scope.