Moving back in time from the early colonial to the late pre-colonial period we evaluate the hypothesis asserting the migratory movement of Cariban-speaking groups from the Middle Orinoco River area towards north-central Venezuela. The explanation in vogue maintains that the migration followed fluvial routes and occurred between 1350 and 1150 BP (AD 600-800). We examine archaeological, linguistic, ethnohistorical, genetic, and ecological data seeking similarities between the Orinoco emigrants and their northcentral Venezuelan descendants. As a result, we propose an alternative terrestrial/fluvial route and suggest these events occurred between 1150 and 1050 BP (AD 800-900). The route first proceeded upstream along rivers of the central llanos and later followed a natural terrestrial geomorphological corridor into the Lake Valencia Basin. We argue that, while future interdisciplinary (especially archaeo-linguistic and bioarchaeological) research is needed to further assess the results of these analyses, the Orinocan descendants in northcentral Venezuela emerge as one of the most dynamic sociopolitical Cariban-speaking entities in all northeastern South America and the insular Caribbean on the eve of the European Conquest.