Prehypertension and Cardiovascular Morbidity

Liszka, Heather A.; Mainous, Arch G.; King, Dana E.; Everett, Charles J.; Egan, Brent M.

doi:10.1370/afm.312

Cited by 205 publications

(147 citation statements)

References 25 publications

(21 reference statements)

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“…13,[27][28][29][30][31][32][33] Likewise, a number of large-scale cohort studies have reported significant effects of prehypertension separately on the risks of stroke 13,29,30,32 and coronary heart disease. 13,29 The present analysis from the APCSC confirmed the results from the previous observational studies and provided more detailed information about the separately significant associations of prehypertension with all of the major types of CVD, including ischemic and hemorrhagic stroke in the Asia-Pacific region.…”

Section: Discussionmentioning

confidence: 99%

Effects of Prehypertension and Hypertension Subtype on Cardiovascular Disease in the Asia-Pacific Region

et al. 2012

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Abstract-The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure defined blood pressure (BP) levels of 120 to 139/80 to 89 mm Hg as prehypertension and those of Ն140/90 mm Hg as hypertension. Hypertension can be divided into 3 categories, isolated diastolic (IDH; systolic BP Ͻ140 mm Hg and diastolic BP Ն90 mmHg), isolated systolic (systolic BP Ն140 mm Hg and diastolic BP Ͻ90 mmHg), and systolic-diastolic hypertension (systolic BP Ն140 mm Hg and diastolic BP Ն90 mmHg). Although there is clear evidence that isolated systolic hypertension and systolic-diastolic hypertension increase the risks of future vascular events, there remains uncertainty about the effects of IDH. The objective was to determine the effects of prehypertension and hypertension subtypes (IDH, isolated systolic hypertension, and systolic-diastolic hypertension) on the risks of cardiovascular disease (CVD) in the Asia-Pacific Region. The Asia Pacific Cohort Studies Collaboration is an individual participant data overview of cohort studies in the region. This analysis included a total of 346570 participants from 36 cohort studies. Outcomes were fatal and nonfatal CVD. The relationship between BP categories and CVD was explored using a Cox proportional hazards model adjusted for age, cholesterol, and smoking and stratified by sex and study. Compared with normal BP (Ͻ120/80 mmHg), hazard ratios (95% CIs) for CVD were 1.41 (1.31-1.53) for prehypertension, 1.81 (1.61-2.04) for IDH, 2.18 (2.00 -2.37) for isolated systolic hypertension, and 3.42 (3.17-3.70) for systolic-diastolic hypertension. Separately significant effects of prehypertension and hypertension subtypes were also observed for coronary heart disease, ischemic stroke, and hemorrhagic stroke. In the Asia-Pacific region, prehypertension and all hypertension subtypes, including IDH, thus clearly predicted increased risks of CVD. Key Words: prehypertension Ⅲ hypertension Ⅲ hypertension subtype Ⅲ isolated diastolic hypertension Ⅲ cardiovascular disease Ⅲ coronary heart disease Ⅲ stroke C ardiovascular disease (CVD) is a leading cause of premature death and disability globally.

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Section: Discussionmentioning

confidence: 99%

Effects of Prehypertension and Hypertension Subtype on Cardiovascular Disease in the Asia-Pacific Region

et al. 2012

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“…However, Seventh Report of the Joint National Committee (JNC-7) provides a newer guideline on classification of hypertension [5,6]; SBP between 120-139 mmHg or DBP between 80-89 mmHg fall into prehypertension [7] and possess higher cardiovascular and renal risk in future [8,9]. Prehypertension is commonly prevalent in the general population [10] but there are only a few studies on the prevalence and risk factors available in Indians [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Impact of Prehypertension on Left Ventricular Structure, Function and Geometry

Garg

Goel

2014

JCDR

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Background: Awareness of prevalence, determinants, and prognosis of asymptomatic untreated prehypertension is still lacking especially in India and subcontinent. The present study was to assess the effects of prehypertension on structure, function and geometrical pattern of left ventricle on the basis of left ventricular mass (LVM), left ventricular mass indexed to height (LVMI/Ht), and relative wall thickness (RWT) recorded by echocardiography based on the American society of echocardiography (ASE) convention.

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“…6 This is increasingly being shown to be an independent risk factor of hypertension 7,8 and cardiovascular morbidity. [9][10][11] In addition, individuals with prehypertension are a potential target population for promotion of lifestyle modifications aimed at prevention of hypertension and cardiovascular diseases. Little is known about the magnitude of prehypertension and its associated factors in Africa.…”

Section: Introductionmentioning

confidence: 99%

Prevalence, associated factors and relationship between prehypertension and hypertension: a study of two ethnic African populations in Northern Nigeria

et al. 2010

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To determine the prevalence and relationship between prehypertension and hypertension, we studied 782 ethnic Hausa and Fulanis (men, 409; women, 373) aged 38.9 ± 13.9 years recruited by multistage cluster sampling. Demographic, anthropometry, metabolic and JNC VII-based blood pressure categories were obtained and analysed using univariate and multivariate models. The prevalence rates of prehypertension and hypertension were 58.7% (men 59.2%, women 58.2%) and 24.8% (men 25.9%, women 23.6%), respectively. Only 16.5% of the population had JNC VII defined optimum blood pressure. Compared to hypertension, prehypertension had earlier onset (second versus third decade) and peak (fourth versus fifth decade) of life. The peak and trough prevalence of hypertension and prehypertension, respectively were observed in the 5th decade of life. Obesity, abnormalities of glucose metabolism and insulin resistance were the major factors associated with prehypertension and hypertension. Multivariate analysis identified obesity and impaired glucose tolerance as independent predictors of hypertension. Of those with hypertension, 13.9% were aware of their high blood pressure status of which 85.7% were commenced on treatment and 12.5% achieved blood pressure control. Overall, 1.5% of the study population had blood pressure o140/90 mm Hg. It is concluded that less than 20% of people of Hausa and Fulani ethnicities had optimum blood pressure. These are predominantly in their second decade of life suggesting that rise in blood pressure begins early in this population. The fifth decade of life may represent a period of transition from prehypertension to hypertension.

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Prehypertension and Cardiovascular Morbidity

Cited by 205 publications

References 25 publications

Effects of Prehypertension and Hypertension Subtype on Cardiovascular Disease in the Asia-Pacific Region

Effects of Prehypertension and Hypertension Subtype on Cardiovascular Disease in the Asia-Pacific Region

Impact of Prehypertension on Left Ventricular Structure, Function and Geometry

Prevalence, associated factors and relationship between prehypertension and hypertension: a study of two ethnic African populations in Northern Nigeria

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