Prehypertension and risk of cardiovascular disease in Chinese adults

Gu, Dongfeng; Chen, Jing; Wu, Xigui; Duan, Xin; Jones, Daniel W.; Huang, Jianfeng; Chen, Chung-Shiuan; Chen, Ji-Chun; Kelly, Tanika N.; Whelton, Paul K.; He, Jiang

doi:10.1097/hjh.0b013e328323ad89

Cited by 67 publications

(64 citation statements)

References 31 publications

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“…To our best knowledge, there were 3 prior studies about prehypertension and CVD risk conducted in Chinese populations 2, 4, 5. The average age of participants from all the previously described 3 studies in Chinese populations was ≈55 years, which was ≈8 years younger than the average age of 63 years in our study.…”

Section: Discussionmentioning

confidence: 55%

“…In the other 2 studies among Chinese populations,4, 5 prehypertension was defined as systolic BP 120 to 139 mm Hg and diastolic BP 80 to 90 mm Hg, without further categorization into a low or high range. In a follow‐up study conducted in Taiwan, prehypertension was associated with a 73% (HR, 1.73; 95% CI, 1.00–2.98) higher risk of cardiovascular events 4.…”

Section: Discussionmentioning

confidence: 99%

“…In their subgroup analysis, the significant association with CVD mortality was only observed in participants with at least 1 CVD risk factor (RR, 1.19; 95% CI, 1.11–1.28) but not in those without any CVD risk factor (RR, 1.11; 95% CI, 0.91–1.36). This led the authors to conclude that medical treatment of prehypertension may not be as beneficial as treatment of established hypertension in the general population 5. In accordance with our results, this study also found that, although the association was significant among participants <65 years of age (HR, 1.29; 95% CI, 1.17–1.43), the association was weaker and of borderline significance among participants ≥65 years of age (HR, 1.08; 95% CI, 0.99–1.17) 5…”

Section: Discussionmentioning

confidence: 99%

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Association of “Elevated Blood Pressure” and “Stage 1 Hypertension” With Cardiovascular Mortality Among an Asian Population

Talaei

Hosseini

Koh

et al. 2018

JAHA

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BackgroundThe new American College of Cardiology/American Heart Association high blood pressure (BP) guidelines in the United States have lowered definition of hypertension by defining normal as systolic/diastolic BP <120/80 mm Hg; elevated BP as systolic between 120 and 129 mm Hg and diastolic <80 mm Hg; and stage 1 hypertension as systolic between 130 and 139 mm Hg or diastolic between 80 and 89 mm Hg.Methods and ResultsWe investigated the association between the new hypertension definition and cardiovascular disease mortality among Chinese in Singapore. We used data from 30 636 participants of a population‐based cohort, the SCHS (Singapore Chinese Health Study), who had BPs measured using a standard protocol at ages 46 to 85 years between 1994 and 2005. Information on lifestyle factors was collected at recruitment (1993–1998) and follow‐up 1 interviews (1999 and 2004). Mortality was identified via nationwide registry linkage up to December 31, 2016. Neither elevated BP (hazard ratio, 0.89; 95% confidence interval, 0.74–1.07) nor stage 1 hypertension (hazard ratio, 0.94; 95% confidence interval, 0.81–1.11) was associated with increased risk of cardiovascular mortality compared with normal BP in the whole cohort. Stage 1 hypertension was associated with increased cardiovascular risk only in those <65 years of age and without a history of cardiovascular disease (hazard ratio, 1.40; 95% confidence interval, 1.01–1.94), but not in those ≥65 years of age or with a history of cardiovascular disease.ConclusionsOur data suggest that the newly defined stage 1 hypertension may not be associated with increased cardiovascular mortality across all ages among Chinese in Singapore, but that the at‐risk subpopulation is limited to those <65 years of age and without a prior cardiovascular disease.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association of “Elevated Blood Pressure” and “Stage 1 Hypertension” With Cardiovascular Mortality Among an Asian Population

Talaei

Hosseini

Koh

et al. 2018

JAHA

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“…This optimal number-needed-to-treat to prevent a CVD related event was significantly smaller in PreHTN patients with a history of CVD or diabetes (34 for incidence and 44 for mortality) compared with those without (115 for incidence and 352 for mortality). 27 The CVD mortality among the Japanese (12 928 subjects followed) was 1.32 (0.59-2.94), very similar to the Chinese population, with a 7% population attributable fraction in the 40-64 year age group. 28 Among the Omani adults with prediabetes (40.9%), 54.1% had a history of PreHTN.…”

Section: Discussionmentioning

confidence: 73%

Prehypertension in disease-free adults: a marker for an adverse cardiometabolic risk profile

et al. 2010

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“…13 In the Chinese population, prehypertension has been found to be associated with increased risk of hypertension and major cardiovascular diseases. 14,15 However, the temporal changes in prehypertension prevalence in the Chinese population are still unknown.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of prehypertension and hypertension in a Chinese rural area from 1991 to 2007

Yang

Cheng

et al. 2010

Hypertens Res

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Shandong Province is located in the east of China. The province is characterized by robust economic development, with a rural population accounting for 56% of the total population. However, no data are available regarding temporal changes in the prevalence, awareness, treatment and control of hypertension among this population. Three independent cross-sectional surveys were performed in 1991 (n¼8359), 2002 (n¼18922) and 2007 (n¼20167) in the rural area population, aged 35-74 years. The sampling included a survey on blood pressure and associated risk factors. Although the rate of smoking and alcohol consumption decreased significantly from 1991 to 2007, the prevalence of overweight and obesity increased, whereas that of high-strength physical activity decreased remarkably. In 1991, 2002 and 2007, the prevalence of prehypertension was 33.8, 61.5 and 54.6%, respectively. The prevalence of hypertension was 20.4, 24.5 and 30.6%, respectively. Overall, the rate of hypertension awareness, treatment and control showed a steady increase over the 16-year period, although the control rate of hypertension is still far from being satisfactory. In conclusion, among the Chinese rural population, the prevalence of prehypertension and hypertension increased significantly from 1991 to 2007. Public health programs are required to improve this situation in Chinese rural populations.

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Prehypertension and risk of cardiovascular disease in Chinese adults

Abstract: Prehypertension was related to an increased risk of CVD. Treatment of prehypertension among patients with a history of CVD or diabetes was as beneficial as treatment of stage 1 hypertensive patients without a history of CVD or diabetes.

Cited by 67 publications

References 31 publications

Association of “Elevated Blood Pressure” and “Stage 1 Hypertension” With Cardiovascular Mortality Among an Asian Population

Association of “Elevated Blood Pressure” and “Stage 1 Hypertension” With Cardiovascular Mortality Among an Asian Population

Prehypertension in disease-free adults: a marker for an adverse cardiometabolic risk profile

Prevalence of prehypertension and hypertension in a Chinese rural area from 1991 to 2007

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