Prehypertension, Diabetes, and Cardiovascular Disease Risk in a Population-Based Sample

Zhang, Ying; Lee, Elisa T.; Devereux, Richard B.; Yeh, Jeunliang; Best, Lyle G.; Fabsitz, Richard R.; Howard, Barbara V.

doi:10.1161/01.hyp.0000205119.19804.08

Cited by 221 publications

(158 citation statements)

References 23 publications

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“…Many cross-sectional studies of different populations demonstrated that prehypertensive individuals had higher total cholesterol, LDL-C, TG and lower HDL-C than normotensive subjects [6][7][8][20][21][22][23][24][25][26][27][28][29][30] . Some prospective studies also showed that dyslipidemia could predict occurrence of incident hypertension by years [31][32][33] .…”

Section: Discussionmentioning

confidence: 99%

“…A study of 1999 to 2000 NHANES data has suggested that 64% of prehypertensive subjects have ≥1 other abnormal CVD risk factors, the percentage increased to 94% in those ≥60 years of age 6 . The risk ratios for obesity, dyslipidemia, metabolic syndrome, and diabetes are all greater in prehypertensive than normotensive subjects 7,8 . The dyslipidemias represent heterogenic metabolic disorders.…”

Section: Introductionmentioning

confidence: 96%

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Prehypertension in dyslipidemic individuals; relationship to metabolic parameters and intima-media thickness

Karásek

Vaverková²,

Halenka³

et al. 2013

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Introduction. Like hypertension, prehypertension is associated with cardiovascular disease. Aims. The aim of this study was to evaluate: a) the prevalence of prehypertension/hypertension in individuals with various dyslipidemic phenotypes; b) the relation between blood pressure (BP) and other risk factors for atherosclerosis; c) atherogenic potential of prehypertension by the assessment of intima-media thickness of the arteria carotis communis (IMT). Methods. 667 clinically asymptomatic subjects were divided into four dyslipidemic phenotypes (DLP) according to apolipoprotein B (apoB) and triglycerides (TG): DLP1 (n=198, normo-apoB/normo-TG), DLP2 (n=179, normo-apoB/ hyper-TG), DLP3 (n=87, hyper-apoB/normo-TG), DLP4 (n=203, hyper-apoB/hyper-TG). DLP1 served as a control group. Results. There was significantly higher prevalence of prehypertension and hypertension in subjects with dyslipidemia (DLP2 43.0%, 41.3%; DLP3 42.5%, 29.9%; DLP4 42.4%, 47.8%) than in normolipidemic individuals (DLP1 32.8%, 20.2%). Systolic and diastolic blood pressure (SBP + DBP) correlated with age, total cholesterol, TG, non-HDL-cholesterol, body mass index and waist circumference; SBP additionally with C-peptide, fasting glycemia; DBP additionally with apoB, homeostasis model assessment (HOMA) and plasminogen activator inhibitor-1. The IMT of hypertensive and of prehypertensive subjects was higher than that of subjects with normal BP in all DLPs. Conclusions. The prevalence of prehypertension was higher in all dyslipidemic patients. The common prevalence of prehypertension/hypertension was highest in the hypertriglyceridemic subjects. Prehypertensive and hypertensive patients had higher IMT than normotensive individuals in all DLPs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Prehypertension in dyslipidemic individuals; relationship to metabolic parameters and intima-media thickness

Karásek

Vaverková²,

Halenka³

et al. 2013

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…Its treatment is one of the major risk factors for the development of cardiovascular disease, stroke, and the end stage of renal disease (Zhang et al, 2006). Among the processes associated with hypertension, angiotensin I converting enzyme (ACE) plays an important role in the regulation of blood pressure.…”

Section: Introductionmentioning

confidence: 99%

The Novel Angiotensin I Converting Enzyme Inhibitory Peptide from Rainbow Trout Muscle Hydrolysate

Kim¹,

Byun

2012

Fisheries and aquatic sciences

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The purpose of this study was the purification and characterization of an angiotensin I converting enzyme (ACE) inhibitory peptide purified from enzymatic hydrolysates of rainbow trout Oncorhynchus mykiss muscle. After removal of lipid, the approximate composition analysis of the rainbow trout revealed 24.4%, 1.7%, and 68.3% for protein, lipid, and moisture, respectively. Among six hydrolysates, the peptic hydrolysate exhibited the highest ACE inhibitory activity. We attempted to purify ACE inhibitory peptides from peptic hydrolysate using high performance liquid chromatography on an ODS column. The IC 50 value of purified ACE inhibitory peptide was 63.9 μM. The amino acid sequence of the peptide was identified as Lys-Val-Asn-Gly-Pro-Ala-Met-SerPro-Asn-Ala-Asn, with a molecular weight of 1,220 Da, and the Lineweaver-Burk plots suggested that they act as a competitive inhibitor against ACE. Our study suggested that novel ACE inhibitory peptides purified from rainbow trout muscle protein may be beneficial as anti-hypertension compounds in functional foods.

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“…Estos resultados son muy similares a los obtenidos en el estudio The Strong Heart Study 2006, donde la prehipertensión fue más frecuente en menores de 60 años que en los de mayor edad, sobre todo si los sujetos padecen concomitantemente diabetes mellitus. En este estudio se demostró que la intolerancia a la glucosa o la alteración de la glucosa en ayunas aumentan en gran medida el 45 riesgo de enfermedad cardiovascular en personas prehipertensas.…”

Section: Discussionunclassified

Frecuencia de preenfermedades en el Hospital Nacional

Onishi¹,

Delor²

2015

Rev. virtual Soc. Parag. Med. Int

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+ Artículo Original Frecuencia de preenfermedades en el Hospital NacionalFrequency of pre-diseases in the National Hospital Resultados: ingresaron al estudio 267 sujetos, siendo 64 varones con edad media 52±18 años y 203 mujeres con edad media 53±20 años (p 0,62). Se detectaron las sgtes. preenfermedades: prediabetes mellitus 31%, prehipertensión arterial sistólica 32%, prehipertensión arterial diastólica 46%, preobesidad 36%, prehipercolesterolemia 36%, prehipertrigliceridemia 15% y prehiperuricemia 60%. Conclusiones: las preenfermedades más frecuentes fueron la prehiperuricemia y la prehipertensión arterial diastólica. Palabras claves: preenfermedad, prediabetes mellitus, prehipertensión arterial, preobesidad, prehiperuricemia AbstractIntroduction: Preventive Medicine emphasizes the detection of pre-diseases like pre-diabetes mellitus, prearterial hypertension, pre-obesity and pre-hyperuricemia with the purpose of intervening opportunely in the development of these diseases. Objectives: To investigate the prevalence of pre-diseases in adult patients

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Prehypertension, Diabetes, and Cardiovascular Disease Risk in a Population-Based Sample

Cited by 221 publications

References 23 publications

Prehypertension in dyslipidemic individuals; relationship to metabolic parameters and intima-media thickness

Prehypertension in dyslipidemic individuals; relationship to metabolic parameters and intima-media thickness

The Novel Angiotensin I Converting Enzyme Inhibitory Peptide from Rainbow Trout Muscle Hydrolysate

Frecuencia de preenfermedades en el Hospital Nacional

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