Preimplantation genetic diagnosis (PGD) for HLA typing: bases for setting up an open international collaboration when PGD is not available

Bellavia, Marina; Weid, Nicolas von der; Peddes, Christina; Jacquemont, Sébastien; Liebaers, Inge; Hohlfeld, P.; Wunder-Galié, Dorothea; Ziegler, Dominique de

doi:10.1016/j.fertnstert.2009.11.007

Cited by 5 publications

(5 citation statements)

References 8 publications

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“…Collaboration like this may be performed nationally or internationally as they are routinely being performed at IHR/RGI as well as at other leading centers, even if the couple resides where PGD procedures are banned. 124 In summary, ART centers should evaluate their experience and outcome of IVF for PGD and decide whether they wish to offer it locally to patients or to collaborate with another more experienced center. Centers involved in PGD should follow the guidelines published by ESHRE and/or PGDIS.…”

Section: Clinical Expertise In Ivf-pgd Treatmentsmentioning

confidence: 99%

Clinical Management of in Vitro Fertilization with Preimplantation Genetic Diagnosis

Tur-Kaspa

2012

Semin Reprod Med

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Patients who undergo in vitro fertilization (IVF) because of preimplantation genetic diagnosis (PGD) require different clinical management than those who come in because of infertility alone. PGD adds a "fourth dimension" to the emotional aspect of a patients' assisted reproductive technology treatment. It significantly decreases the number of embryos available for transfer by 25 to 81%, and therefore ovarian stimulation for IVF with PGD should be tailored individually, taking into account patients' safety and estimated ovarian reserve. Recent studies showed that with increased number of oocytes retrieved, the higher the chance to have an embryo transfer and normal cryopreserved blastocysts. With adequate ovarian stimulation, there is no cutoff for the numbers of oocytes/embryos needed to start PGD with, especially for younger patients. Patient-friendly protocols, such as those based on gonadotropin-releasing hormone antagonist and vaginal progesterone support may be used. Elective single embryo transfer and blastocysts cryopreservation to avoid multiple pregnancies may be offered with PGD. The benefit of adding preimplantation genetic screening to IVF treatment is still controversial, and evidence-based data on 24-chromosome testing of polar bodies or trophectoderm is needed before it may be implemented into routine patient care.This review discusses the clinical management of IVF with PGD based on the best available data and my personal clinical experience as a reproductive specialist with >1000 IVF/intracytoplasmic sperm injection-PGD cycles. The information provided here will assist reproductive specialists, nurses, geneticists, genetic counselors, and embryologists to better counsel and treat couples who wish to conceive with a healthy child through IVF with PGD. It is time for PGD to be viewed as a modern modality of preventive medicine. As such, it should be incorporated into national health-care systems and be covered by medical insurance.

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Section: Clinical Expertise In Ivf-pgd Treatmentsmentioning

confidence: 99%

Clinical Management of in Vitro Fertilization with Preimplantation Genetic Diagnosis

Tur-Kaspa

2012

Semin Reprod Med

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“…It is distinguished from inferential statistics (or inductive statistics), in that descriptive statistics aim to summarize a sample, rather than use the data to learn about the population that the sample of data is thought to represent. This generally means that descriptive statistics, unlike inferential statistics, are not developed on the basis of probability theory (Basille, 2009;Bellavia, 2010). Even when a data analysis draws its main conclusions using inferential statistics, descriptive statistics are generally also presented.…”

Section: Discussionmentioning

confidence: 99%

“…Edwards and Gardner preformed first known embryo biopsy in 1968 on rabbits (Bellavia, 2010). Then used in human first in United Kingdom along with PGD in the mid-1980s as alternative to prenatal diagnoses.…”

Section: Introductionmentioning

confidence: 99%

The Power of Options: The Solution for Healthier Society and Better Economy

Al-Abdulhadi

2017

RHS

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“…The chance of being a normal embryo in an autosomal recessive disease is 3 in 4 and the likelihood of being HLA compatible is 1 in 4 which gives an overall likelihood of 3 in 16 embryos being suitable for transfer. The first PGD for this indication was applied to a family with Fanconi anemia (Verlinsky et al, 2001a) and later extended to Wiscott-Aldrich syndrome, Thalassemia, X-linked adrenoleukodystrophy, hyperimmunoglobulin M syndrome (Rechitsky et al, 2004) X-linked chronic granulomatous disease (Reichenbach et al, 2008) and Diamond-Blackfan anemia (Bellavia et al, 2010).…”

Section: Pgd For Stem Cell Transplantation ("Designer Babies")mentioning

confidence: 99%

Preimplantation Genetic Diagnosis and Selection

Coşkun

Qubbaj

2010

Journal of Reproductive and Stem Cell Biotechnology

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The availability of assisted reproductive technologies and advances in molecular biology gave rise to preimplantation genetic diagnosis (PGD). PGD is an early form of prenatal diagnosis and determines the genotype of an embryo before implantation takes place to avoid the implantation of diseased embryos. This requires couples to adhere to a strict family planning and effective contraceptive strategy, and undergo in vitro fertilization (IVF) treatment. During IVF, sampling of the cells can be performed at different developmental stages from polar body biopsy to trophectoderm cells from the blastocysts. It is indicated in couples with a family history of monogenic autosomal or X-linked recessive or dominant disorders and in detecting chromosomal aberrations of the embryos. The genetic diagnosis is performed using appropriate molecular testing which might include polymerase chain reaction, fluorescent in situ hybridization, comparative genomic hybridization or microarrays. PGD is now a wellestablished procedure and offers an alternative reproductive choice for couples who are at risk of an affected child. In this review, the past, present and future aspect of PGD will be covered.

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Preimplantation genetic diagnosis (PGD) for HLA typing: bases for setting up an open international collaboration when PGD is not available

Cited by 5 publications

References 8 publications

Clinical Management of in Vitro Fertilization with Preimplantation Genetic Diagnosis

Clinical Management of in Vitro Fertilization with Preimplantation Genetic Diagnosis

The Power of Options: The Solution for Healthier Society and Better Economy

Preimplantation Genetic Diagnosis and Selection

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