Preimplantation growth factor physiology

Kaye, Peter L.

doi:10.1530/ror.0.0020121

Cited by 92 publications

(21 citation statements)

References 21 publications

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“…Maternal diabetes downregulates IR and IGF1R signaling, delays blastocyst development and gastrulation and increases apoptotic cell death in the embryonic disc. The 'double face' of IGFs -growth factor of the embryoblast (Kaye 1997, Markham & Kaye 2003, Navarrete Santos et al 2004a) and pro-apoptotic effects in bovine blastocysts (Velazquez et al 2011) -needs further clarification to improve understanding of potential mechanism(s) of periconceptional programming and diabetogenous embryopathies.…”

Section: Diabetes Mellitusmentioning

confidence: 99%

Rabbit as a reproductive model for human health

Fischer¹,

Chavatte‐Palmer²,

Viebahn³

et al. 2012

Reproduction

182

149

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The renaissance of the laboratory rabbit as a reproductive model for human health is closely related to the growing evidence of periconceptional metabolic programming and its determining effects on offspring and adult health. Advantages of rabbit reproduction are the exact timing of fertilization and pregnancy stages, high cell numbers and yield in blastocysts, relatively late implantation at a time when gastrulation is already proceeding, detailed morphologic and molecular knowledge on gastrulation stages, and a hemochorial placenta structured similarly to the human placenta. To understand, for example, the mechanisms of periconceptional programming and its effects on metabolic health in adulthood, these advantages help to elucidate even subtle changes in metabolism and development during the pre-and peri-implantation period and during gastrulation in individual embryos. Gastrulation represents a central turning point in ontogenesis in which a limited number of cells program the development of the three germ layers and, hence, the embryo proper. Newly developed transgenic and molecular tools offer promising chances for further scientific progress to be attained with this reproductive model species.

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Section: Diabetes Mellitusmentioning

confidence: 99%

Rabbit as a reproductive model for human health

Fischer¹,

Chavatte‐Palmer²,

Viebahn³

et al. 2012

Reproduction

182

149

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“…Glucose levels are low in the oviduct during the early cleavage phase but increase as the embryo enters the uterus to levels more in line with altered embryonic needs following compaction as the embryo increases both its reliance on glucose as an energy substrate and its ability to respond to exogenous growth factors (Kaye 1997). Oviductal and uterine epithelial secretions provide the early embryo with essential nutrients, electrolytes, macromolecules and growth factors required for optimal growth prior to implantation.…”

Section: The Embryo and Its Environmentmentioning

confidence: 99%

“…Different cytokines act through one or more downstream pathways, of which the most prominent in embryos are the phosphatidylinositol-3 kinase-protein kinase B (PI3K-AKT), Janus kinase/signal transducer and activator of transcription (JAK/ STAT), and mitogen-activated protein kinase (MAPK) pathways. For some cytokine (Kaye 1997;Richter 2008) receptors, ligation activates only PI3K-AKT, while others activate all three signalling pathways ( …”

Section: Cytokine Receptor Signal Transduction In Pre-implantation Emmentioning

confidence: 99%

“…A range of cytokines secreted by the oviduct and uterus are amongst the local signalling agents that mediate communication between the embryo and maternal tissues. Although embryos clearly can develop in vitro in simple culture media in the absence of exogenous cytokines, there is compelling evidence that factors released by the maternal tract have paracrine cell-cell signalling actions that promote embryo health and developmental potential (Kaye 1997;Richter 2008). These factors act in synergy with autocrine growth factors and cytokines synthesised by the embryo itself.…”

Section: Introductionmentioning

confidence: 99%

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Cell Signaling During Mammalian Early Embryo Development

Leese¹,

Brison²

2015

Advances in Experimental Medicine and Biology

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Advances in Experimental Medicine and Biology presents multidisciplinary and dynamic findings in the broad fields of experimental medicine and biology. The wide variety in topics it presents offers readers multiple perspectives on a variety of disciplines including neuroscience, microbiology, immunology, biochemistry, biomedical engineering and cancer research. Advances in Experimental Medicine and Biology has been publishing exceptional works in the field for over 30 years and is indexed in Medline, Scopus, EMBASE, BIOSIS, Biological Abstracts, CSA, Biological Sciences and Living Resources (ASFA-1), and Biological Sciences. The series also provides scientists with up to date information on emerging topics and techniques. This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. PrefaceInterest in cell signalling in the early embryo extends over the last 30 years, following extensive research on this topic in somatic cells largely in the context of exogenous growth factors and hormones. Thus, Edirisinghe and Wales (1985), working on preimplantation mouse embryos examined the effect of a variety of agents: glucagon, insulin, adrenaline, cAMP, theophylline and caffeine on glucose metabolism while O'Neill (1985), a pioneer in this field, reported that mouse embryos produced platelet-activating factor (PAF) which stimulated blastocyst rates and cell number. Research then focussed largely on peptide growth factors including their origini.e., whether growth factor ligands and/or receptors were produced by the embryo itself or by the female tract (oviduct and uterus), and their cellular effects, which could be autocrine, paracrine or juxtacrine. A number of excellent reviews of these studies were published: e.g., Schultz and Heyner (1993); Kaye (1997); Kane et al. (1997); Hardy and Spanos (2002).In the last few years interest in embryonic signalling has exploded with (i) the increasing use of ART procedures in animals and humans and the need to improve success rates and safety; (ii) ren...

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“…A role for a peptide/protein secretome was inferred from studies showing that the early embryo expressed a range of putative trophic ligands and also their receptors [6,7]. Evidence that the addition of one or more of these ligands to culture media caused an improvement in the rate of embryo development in vitro was indicative of a functional role for their secretion by the embryo [8,9].…”

Section: Introductionmentioning

confidence: 99%

Characterization of a diverse secretome generated by the mouse preimplantation embryo in vitro

Beardsley

O’Neill

2010

Reprod Biol Endocrinol

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This study investigates the suitability of surface-enhanced laser desorption and ionization time-of-flight (SELDI-TOF) and electrospray ionization (ESI) mass spectrometry for analysis of the proteins released by the mouse preimplantation embryo in vitro. SELDI-TOF analysis with CM10 or IMAC30 (but not Q10) protein chips detected a protein peak at m/z ~8570 released by both C57BL6 and hybrid embryos. No other peaks unique to the presence of the embryo were identified with this method. ESI mass spectrometry of tryptic digests of embryo-conditioned media identified a total of 20 proteins released during development from the zygote to blastocyst stage. Four proteins were expressed in at least 7 out of 8 cultures tested, one of these (lactate dehydrogenase B) was in all cultures. A further five proteins were in at least half of the cultures and 11 more proteins were in at least one culture. The expression of two of these proteins is essential for preimplantation embryo development (NLR family, pyrin domain containing 5 and peptidyl arginine deiminase, type VI). A further four proteins detected have roles in redox regulation of cells, and three others are capable of inducing post-translational modifications of proteins. This study shows the feasibility of ESI mass spectrometry for identifying the proteins secreted by the preimplantation embryo in vitro. This analysis identifies a range of targets that now require detailed functional analysis to assess whether their release by the embryo is an important property of early embryo development.

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Preimplantation growth factor physiology

Cited by 92 publications

References 21 publications

Rabbit as a reproductive model for human health

Rabbit as a reproductive model for human health

Cell Signaling During Mammalian Early Embryo Development

Characterization of a diverse secretome generated by the mouse preimplantation embryo in vitro

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