Preimplantation Stress and Development

Feuer, Sky K.; Rinaudo, Paolo

doi:10.1002/bdrc.21022

Cited by 50 publications

(41 citation statements)

References 205 publications

(227 reference statements)

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“…During the IVF process, both gametes and the pre-implantation embryos are exposed to in vitro conditions that do not perfectly recapitulate the normal environment of the Fallopian tube and uterus (Feuer & Rinaudo 2012), in which genome-wide epigenetic reprogramming occurs (Reik 2007, Cockburn & Rossant 2010. Moreover, male and female embryos differ in their chromosomal complement, transcriptome, proteome and subsequent metabolome (Kobayashi et al 2006, Bermejo-Alvarez et al 2010, Gardner et al 2010, and in their epigenetic processes, including X-chromosome inactivation (XCI) (Takagi & Sasaki 1975), DNA methylation (Bermejo-Alvarez et al 2008, Gebert et al 2009) and gene imprinting (Kobayashi et al 2006).…”

Section: Introductionmentioning

confidence: 99%

IVF affects embryonic development in a sex-biased manner in mice

Tan¹,

Wang²,

Zhang³

et al. 2016

Reproduction

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Increasing evidence indicates that IVF (IVF includes in vitro fertilization and culture) embryos and babies are associated with a series of health complications, and some of them show sex-dimorphic patterns. Therefore, we hypothesized that IVF procedures have sex-biased or even sex-specific effects on embryonic and fetal development. Here, we demonstrate that IVF-induced side effects show significant sexual dimorphic patterns from the pre-implantation to the prenatal stage. During the pre-implantation stage, female IVF embryos appear to be more vulnerable to IVF-induced effects, including an increased percentage of apoptosis (7.22G1.94 vs 0.71G0.76, P!0.01), and dysregulated expression of representative sex-dimorphic genes (Xist, Hprt, Pgk1 and Hsp70). During the mid-gestation stage, IVF males had a higher survival rate than IVF females at E13.5 (male:femaleZ1.33:1), accompanied with a female-biased pregnancy loss. In addition, while both IVF males and females had reduced placental vasculogenesis/angiogenesis, the compensatory placental overgrowth was more evident in IVF males. During the late-gestation period, IVF fetuses had a higher sex ratio (male:femaleZ1.48:1) at E19.5, and both male and female IVF placentas showed overgrowth. After birth, IVF males grew faster than their in vivo (IVO) counterparts, while IVF females showed a similar growth pattern with IVO females. The present study provides a new insight into understanding IVF-induced health complications during embryonic and fetal development. By understanding and minimizing these sex-biased effects of the IVF process, the health of IVF-conceived babies may be improved in the future.

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Section: Introductionmentioning

confidence: 99%

IVF affects embryonic development in a sex-biased manner in mice

Tan¹,

Wang²,

Zhang³

et al. 2016

Reproduction

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“…Several studies reporting long-term consequences of in vitro culture or other ART identified a sex bias in the frequency and nature of the long-term effect (FernandezGonzalez et al 2004, Sjoblom et al 2005, Feuer & Rinaudo 2012, Tarin et al 2014. These deleterious effects have pointed to epigenetic alterations produced by ARTs.…”

Section: Sex-specific Long-term Effects Mediated By Assisted Reproducmentioning

confidence: 99%

Early sex-dependent differences in response to environmental stress

et al. 2018

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Developmental plasticity enables the appearance of long-term effects in offspring caused by exposure to environmental stressors during embryonic and foetal life. These long-term effects can be traced to pre-and post-implantation development, and in both cases, the effects are usually sex specific. During preimplantation development, male and female embryos exhibit an extensive transcriptional dimorphism mainly driven by incomplete X chromosome inactivation. These early developmental stages are crucial for the establishment of epigenetic marks that will be conserved throughout development, making it a particularly susceptible period for the appearance of long-term epigenetic-based phenotypes. Later in development, gonadal formation generates hormonal differences between the sexes, and male and female placentae exhibit different responses to environmental stressors. The maternal environment, including hormones and environmental insults during pregnancy, contributes to sex-specific placental development that controls genetic and epigenetic programming during foetal development, regulating sex-specific differences, including sex-specific epigenetic responses to environmental hazards, leading to long-term effects. This review summarizes several human and animal studies examining sex-specific responses to environmental stressors during both the periconception period (caused by differences in sex chromosome dosage) and placental development (caused by both sex chromosomes and hormones). The identification of relevant sex-dependent trajectories caused by sex chromosomes and/or sex hormones is essential to define diagnostic markers and prevention/intervention protocols.Reproduction (2018) 155 R39-R51

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“…According to previous report, there is no significant difference in the distribution of body fat from 4 to 14 years old children between IVF and natural mating [20]. Donjacur et al have detected the distribution of body lean and fat mass in IVF offspring by dual energy X-ray absorptiometry (DEXA) scanning, and found that the fat mass exhibits an obvious increase as the extension of age [5].…”

Section: Discussionmentioning

confidence: 99%

Effect of Vitrified Frozen-Thawed Embryo Transplantation on Glycometabolism of the Offspring Mice

Sui¹,

Xu²

2016

Metabolomics

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Objective: To investigate the change of glycometabolism in the offspring from in vitro fertilization through fresh embryo and vitrified embryo transplantation, and evaluate the effect of vitrification technology on the health of offspring. Materials and method:Offspring mice from fresh embryo transfer (FET) and vitrified embryo transfer (VET) were divided into two groups. Natural mating mice were used as the control. Introperitoneal glucose tolerance (IPGTT) and insulin tolerance test (IPITT) were performed in the adulthood offsprings. Total RNA was extracted from 14.5dpc fetus and neonate livers, and glycometabolism-related genes were detected by quantitative RT-PCR. Results:The glucose levels of IPGTT at 30 min and 120 min in offspring mice from VET were significantly higher than control, and the glucose level at 120 min was significantly higher than that in FET. In liver tissues from 14.5 dpc embryos, the mRNA expression of Igf1 and Igf2 in FET and VET groups, the mRNA expression of Glut8 in VET was significantly higher than that in the control. In livers of newly born mice, the mRNA expression of Igf1 and Igf2 in FET，Glut1 and Glut2 in FET and VET was significantly lower than that in the control.VET and FET, especially VET, may affect the glycometabolism of offspring mice.

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Preimplantation Stress and Development

Cited by 50 publications

References 205 publications

IVF affects embryonic development in a sex-biased manner in mice

IVF affects embryonic development in a sex-biased manner in mice

Early sex-dependent differences in response to environmental stress

Effect of Vitrified Frozen-Thawed Embryo Transplantation on Glycometabolism of the Offspring Mice

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