Some1,2,3,6-tetrahydro-5-(4'-substituted)phenyl-1,1-dimethyl-3-oxo-pyridinium bromides were synthesized from the commercially available p-substituted phenacyl bromides and N,N-dimethylaminoacetone. The acetophenones were converted in the corresponding phenacyl bromides, which by treatment with N,N-dimethylaminoacetone gave nitrogen quaternary salts, which were turned in the 3oxopyridinium bromides using sodium hydroxide, followed treatment with hydro-bromidric acid, in good yields. All compounds were fully characterized by 1 H and 13 C NMR spectral data and elemental analysis. The main goal for the synthesis of these intermediates is their further application in the synthesis of pyridostigmine derivatives, since pyridostigmine itself is widely used in the treatment of myasthenia gravis, and of Parkinson's and Alzheimer's diseases due to its AChE activity.