Preleukemia: Does it Exist?

Killmann, Sven‐Aage

doi:10.1007/978-3-642-66312-3_6

Cited by 18 publications

(9 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ham's test was repeatedly negative in all three cases. Some hematologists will define the above combination of findings as myelodysplasia while others will prefer to use the term preleukemia, as this clinical situation frequently precedes the onset of acute leukemia [17][18][19][20][21][22][23]. It is generally agreed that there are no clinical or laboratory findings pathognomonic of preleukemia; however, there are a number of abnormal findings which taken together may be defined as preleukemia.…”

Section: Discussionmentioning

confidence: 99%

Pancytopenia with hypercellular bone marrow—a possible paraneoplastic syndrome in carcinoma of the lung: A report of three cases

Shinar

Polliack

1984

American J Hematol

View full text Add to dashboard Cite

Three patients with idiopathic pancytopenia and hypercellular bone marrow who developed carcinoma of the lung within two years of diagnosis are reported. All three patients had macrocytic anemia associated with a megaloblastic marrow in the presence of normal serum vitamin B12 and folic acid levels. Neutropenia with monocytosis, elevated serum muramidase and LAP scores, and increased fetal hemoglobin levels were also found. In all cases Ham's tests were negative with a normal bone marrow karyotype. In all three patients, pancytopenia due to myelodysplasia, a probable preleukemic state, was diagnosed initially prior to the appearance of carcinoma of the lung. One of the patients showed improved leukocyte and platelet counts during chemotherapy, while the other two died before chemotherapy could be administered. In the light of the above findings we suggest that carcinoma of the lung may be the cause of a paraneoplastic syndrome with pancytopenia, particularly in patients with a hypercellular marrow with a normal karyotype.

show abstract

Section: Discussionmentioning

confidence: 99%

Pancytopenia with hypercellular bone marrow—a possible paraneoplastic syndrome in carcinoma of the lung: A report of three cases

Shinar

Polliack

1984

American J Hematol

View full text Add to dashboard Cite

show abstract

“…In various preleukaemic states including aregenerative anaemia a large number of qualitative as well as quantitative abnormalities in all myeloid cells have been described (Sultan 1972, Maldonado 1975, Breton-Gorius et a1 1976, Killmann 1976, Linman & Bagby 1976. Most of these, however, are stable for years and lack definite prognostic value in estimating the risk of the leukaemic development.…”

Section: Discussionmentioning

confidence: 99%

Studies on Human Preleukaemia II In Vitro Colony Forming Capacity in Aregenerative Anaemia with Hypercellular Bone Marrow

Beran

Hast

1978

Scandinavian Journal of Haematology

View full text Add to dashboard Cite

The colony and cluster forming capacity of bone marrow and mononuclear leucocytes and colony:cluster ratio (CCIR) was studied in 23 patients with resistant anaemia and hypercellular bone marrow. Bone marrow controls included 28 patients with iron deficiency, haemolytic, megaloblastic and secondary anaemia as well as 15 haematologically normal subjects and 13 healthy volunteers. Colony formation by blood leucocytes was studied in aregenerative anaemias and in 13 healthy volun‐Colonies and clusters were grown in soft agar cultures in vitro from all control subjects. In normal volunteers the marrow grew between 24 and 201 colonies and 37 to 212 clusters/105 cells with the CCIR of 0.48–2.50. Blood leucocytes produced 6–184 colonies and 6–88 clusters/106 mononuclear cells with CCIR 0.43–2.64. Colony formation and CCIR were largely normal in haematologically intact subjects and patients with anaemia of known etiology. Patients with aregenerative anaemia showed abnormal colony formation by bone marrow and blood cells more often (P < 0.01) than control groups. Only 7 of 23 patients had colony formation within the normal range. Blood leucocytes in 12 out of 18 aregenerative anaemias failed to grow colonies in vitro. The marrow CCIR was below the normal range in all aregenerative anaemias with defective and in 3 with normal colony formation and was significantly lower than in the controls (P < 0.01). Of 19 aregenerative anaemias with defect colony formation 11 died, 7 with acute leukaemia. The in vitro colony formation appears useful for subclassification of anaemic conditions and for identification of patients who may be at higher risk of developing leukaemia.

show abstract

“…1,2 Consequently, as is observed for normal hematopoiesis, LSCs lie at the root of clonal growth and are therefore thought to be responsible for perpetuation of the leukemic population. While the general concept of LSCs is well-established, [3][4][5][6][7][8][9] a formal description of stem cells in AML has only come about as the result of relatively recent studies. Primarily through the efforts of John Dick and colleagues, a specific initial phenotype (CD34 + /CD38 − ) was assigned to the AML stem cell, and the characteristics of this population were defined by transplantation studies using the xenogeneic NOD/SCID mouse model system.…”

Section: Introductionmentioning

confidence: 99%

Unique molecular and cellular features of acute myelogenous leukemia stem cells

Jordan

2002

Leukemia

111

View full text Add to dashboard Cite

It is well known in the field of acute myelogenous leukemia (AML) that many different translocations and genetic aberrancies are found with the various forms of the disease. Indeed, specific translocations are often associated with disease subtypes that manifest themselves through the accumulation of immature myeloid cells at varying stages of differentiation. Moreover, the differentiation state of myeloid blast populations has been utilized as a means of categorizing different AML subtypes (French, American, British, or FAB classification system). Thus, the notion that AML is a family of related but distinct diseases is a common view. Interestingly, however, studies in recent years that have formalized the concept of a leukemic stem cell (LSC) have also begun to define shared developmental, cellular and molecular features amongst the malignant stem cells that give rise to different AML subtypes. Moreover, some of these conserved features appear to be unique to the leukemia stem/progenitor cell population, and are not found in normal hematopoietic stem cells (HSCs). This article will summarize data emerging from the study of LSCs and suggest how distinct molecular and cellular characteristics of the LSC population may provide new opportunities for AML therapy.

show abstract

Preleukemia: Does it Exist?

Cited by 18 publications

References 60 publications

Pancytopenia with hypercellular bone marrow—a possible paraneoplastic syndrome in carcinoma of the lung: A report of three cases

Pancytopenia with hypercellular bone marrow—a possible paraneoplastic syndrome in carcinoma of the lung: A report of three cases

Studies on Human Preleukaemia II In Vitro Colony Forming Capacity in Aregenerative Anaemia with Hypercellular Bone Marrow

Unique molecular and cellular features of acute myelogenous leukemia stem cells

Contact Info

Product

Resources

About