Preleukemic States

Differentiation of Myeloid Leukaemic Cells: New Possibilities for Therapy

“…ARA-C was repeated, with the same dose and schedule, and an identical response was obtained. Selective kill of abnormal cells, unusually sensitive to ARA-C, could be the unique cxplanation, but this is in contrast with what has been observed in many patients with refractory anaemia or other haemopoietic dysplasias (Dreyfus, 1976;Ricci et al, 1978). Also the dose and schedule of ARA-C, as employed in this patient, was milder than that commonly employed for the therapy of AML.…”

“…This is one of the haemopoietic dysplasias or preleukaemic disorders whose study may provide important information on human leukaemia (Dreyfus, 1976;Ricci et al, 1978).…”

Clinical Contribution to the Knowledge of Hemopoietic Dysplasias: Long-Term Follow-Up of 13 Patients with Refractory Anemia

“…Much knowledge of RA remains anecdotal and dispersed, notwith standing its frequency and the remarkable studies by D reyfus [4] and D reyfus et al [5], either for lack of data allowing the precise identifica tion of the patients studied, or for incomplete information on the clinical and hematological evolution. This situation is not by chance, but a logic consequence of the intermediate and complex nature of the disorder.…”

“…This is due to the objective difficulty of separating leukemic from nonleukemic conditions [1,10], and to the relative paucity of adequate information on the clinical characters, laboratory features, and evolution of the multifar ious hemopoietic dysplasias [12,22,23]. The interest in these disorders lies both in the necessity for sharper diagnostic criteria, and the shortage of adequate therapy [4,10,22], Moreover, hemopoietic dysplasias pro vide a natural model, in humans, for investigation of a developing leuke mia, or of a disease situated at the boundary of leukemia [1,10,12,22]. The importance of these points was emphasized during a symposium re cently held in Paris, leading to a proposition for an international registry for hemopoietic dysplasias [8].…”

“…Amongst hemopoietic dysplasias, much space is occupied by a chronic anemia of the elderly, already recognized at the beginning of the century [13], and described today under the general heading of refractory anemia (RA) [4,5],…”