Preliminary Analysis of Functions of the Temporal Lobes in Monkeys

Klüver, Heinrich; Bucy, Paul C.

doi:10.1176/jnp.9.4.606-a

Cited by 241 publications

(224 citation statements)

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“…Other regions noted here had more modest numbers of sensory information (Ottersen, 1982;LeDoux et al, 1991;Turner and Herkenham, 1991;Yasui et al, 1991;Canteras et al, 1992), af€erents related to the state of arousal (Vertes, 1991), input about planning of viscero-and somatomotor aspects ofbehaviors (Price et al, 19871, and cognitive input from several polymodal association fields of the cerebral cortex (Ottersen, 1982;Canteras et al, 1992). Lesion studies by Kluver and Bucy (1939) suggested that these nuclei play a critical role in discriminating characteristics of sensory input used for the planning of behavior. This has been substantiated at the behavioral (Murray and Mishkin, 1985) and cellular (Bouma and O'Keefe, 1969) levels.…”

Section: Further Anatomical and Functional Considerationsmentioning

confidence: 74%

Characterization of inducible cyclooxygenase in rat brain

Breder

DeWitt

Kraig

1995

J of Comparative Neurology

497

281

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Considerable debate exists regarding the cellular source of prostaglandins in the mammalian central nervous system (CNS). At least two forms of prostaglandin endoperoxide synthase, or cyclooxygenase (COX), the principal enzyme in the biosynthesis of these mediators, are known to exist. Both forms have been identified in the CNS, but only the distribution of COX 1 has been mapped in detail. In this study, we used Western blot analysis and immunohistochemistry to describe the biochemical characterization and anatomical distribution of the second, mitogen-inducible form of this enzyme, COX 2 in the rat brain. COX 2-like immunoreactive (COX 2-ir) staining occurred in dendrites and cell bodies of neurons, structures that are typically postsynaptic. It was noted in distinct portions of specific cortical laminae and subcortical nuclei. The distribution in the CNS was quite different from COX 1. COX 2-ir neurons were primarily observed in the cortex and allocortical structures, such as the hippocampal formation and amygdala. Within the amygdala, neurons were primarily observed in the caudal and posterior part of the deep and cortical nuclei. In the diencephalon, COX 2-ir cells were also observed in the paraventricular nucleus of the hypothalamus and in the nuclei of the anteroventral region surrounding the third ventricle, including the vascular organ of the lamina terminalis. COX 2-ir neurons were also observed in the subparafascicular nucleus, the medial zona incerta, and pretectal area. In the brainstem, COX 2-ir neurons were observed in the dorsal raphe nucleus, the nucleus of the brachium of the inferior colliculus, and in the region of the subcoeruleus. The distribution of COX 2-ir neurons in the CNS suggests that COX 2 may be involved in processing and integration of visceral and special sensory input and in elaboration of the autonomic, endocrine, and behavioral responses.

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Section: Further Anatomical and Functional Considerationsmentioning

confidence: 74%

Characterization of inducible cyclooxygenase in rat brain

Breder

DeWitt

Kraig

1995

J of Comparative Neurology

497

281

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“…The amygdala and interconnected frontal‐limbic regions. These regions have been implicated in determining the emotional states of others through analysis of facial expressions (Adolphs, Tranel, Damasio, & Damasio, 1995; Morris et al ., 1996) and play a central and complex role in multiple aspects of emotion (Davis & Whalen, 2001; Kluver & Bucy, 1997; LeDoux, 1992). The extrastriate body area (EBA), which has been implicated in the visual perception of human bodies (Downing, Jiang, Shuman, & Kanwisher, 2001).…”

Section: Defining the Social Brainmentioning

confidence: 99%

Brain Mechanisms for Social Perception

Pelphrey

Carter

2008

Annals of the New York Academy of Sciences

184

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In this review, we summarize our research program that has as its goal charting the typical and atypical development of the social brain in children, adolescents, and adults with and without autism. We highlight recent work using virtual-reality stimuli, eye tracking, and functional magnetic resonance imaging that has implicated the superior temporal sulcus (STS) region as an important component of the network of brain regions that supports various aspects of social cognition and social perception. Our work in typically developing adults has led to the conclusion that the STS region is involved in social perception via its role in the visual analysis of others' actions and intentions from biological-motion cues. Our work in adolescents and adults with highfunctioning autism has implicated the STS region as a mechanism underlying social perception dysfunction in this neurodevelopmental disorder. We also report novel findings from a study of biological-motion perception in young children with and without autism.

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“…It has long been known that the amygdala is involved in emotional and motivational information processing (Kluver & Bucy, 1939;Weiskrantz, 1956). In particular, the basolateral complex of the amygdala (BLA) is important for modifying the motivational value of otherwise neutral stimuli through associative learning.…”

Section: Introductionmentioning

confidence: 99%

Lesions of basolateral amygdala impair extinction of CS motivational value, but not of explicit conditioned responses, in Pavlovian appetitive second‐order conditioning

Lindgren

Gallagher

Holland

2003

Eur J of Neuroscience

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The basolateral amygdala (BLA) is important for the modification of the motivational significance of events through associative learning. In previous work, we found that BLA was critical for the acquisition of conditioned reinforcement value to a visual conditioned stimulus (CS) paired with food. Unlike normal rats, rats with neurotoxic lesions of the BLA failed to acquire Pavlovian second-order conditioning to an auditory stimulus paired with the first-order visual CS in the absence of food. In this experiment, we examined the role of BLA in the extinction of the previously acquired conditioned reinforcement value of a Pavlovian CS. Rats received first-order visual CS-food pairings prior to either BLA- or sham-lesions. Subsequent CS-alone extinction training reduced the ability of the visual CS to reinforce second-order conditioning of an auditory stimulus in the sham-lesioned rats, but not in the BLA-lesioned rats. Despite this persistence of the conditioned reinforcement value of the visual first-order CS in the BLA-lesioned rats, no effects of the lesions were observed on extinction of the explicit behavioural conditioned responses elicited by that CS.

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Preliminary Analysis of Functions of the Temporal Lobes in Monkeys

Cited by 241 publications

References 0 publications

Characterization of inducible cyclooxygenase in rat brain

Characterization of inducible cyclooxygenase in rat brain

Brain Mechanisms for Social Perception

Lesions of basolateral amygdala impair extinction of CS motivational value, but not of explicit conditioned responses, in Pavlovian appetitive second‐order conditioning

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