Preliminary analysis of low-level alcohol use and suicidality with children in the adolescent brain and cognitive development (ABCD) baseline cohort

Aguinaldo, Laika D.; Goldstone, Aimée; Hasler, Brant P.; Brent, David A.; Coronado, Clarisa

doi:10.1016/j.psychres.2021.113825

Cited by 8 publications

(12 citation statements)

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“…Tragically, more than a half of adolescents who die by suicide have previous records of suicide attempts and self-harming behaviors ( 4 ), which start during childhood and persist over several years ( 5 ). Suicidality in children, here defined as an umbrella term that includes both suicidal ideation (SI) and suicide attempts (SAs) ( 6 – 8 ), is also significantly associated with psychiatric disorders in later life, suggesting intrinsic etiological connections between suicide risk and mental health that start at earlier developmental periods. Understanding the etiological basis of suicidality in children may facilitate prevention and early intervention strategies ( 9 , 10 ).…”

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confidence: 99%

Genetic Association of Attention-Deficit/Hyperactivity Disorder and Major Depression With Suicidal Ideation and Attempts in Children: The Adolescent Brain Cognitive Development Study

Lee

Doyle

et al. 2022

Biological Psychiatry

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confidence: 99%

Genetic Association of Attention-Deficit/Hyperactivity Disorder and Major Depression With Suicidal Ideation and Attempts in Children: The Adolescent Brain Cognitive Development Study

Lee

Doyle

et al. 2022

Biological Psychiatry

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Section: Introductionmentioning

confidence: 99%

“…Alcohol use is linked to suicidal thoughts and behaviors during early adolescence (prepubescence) [ 1 ]. In our prior research, early adolescents who reported lifetime alcohol use (i.e., ≥a sip) showed a nearly two-fold increase in their odds of lifetime suicidal ideation and attempts, compared to early adolescents with no previous alcohol use [ 1 ]. Given that the alcohol use (ALC)–suicidal thoughts and behaviors (STB) association can be detected in early adolescence (as young as age 9), it is important to determine the mechanisms that may increase vulnerability to the ALC-STB association, given that the comorbidity is particularly deadly [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Early life (prepubescent) ALC, STBs, reward responsivity, and cognitive control are critical risk factors that share similar characteristics and predict addictive and suicidal behaviors [ 1 , 3 , 7 , 8 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 22 , 23 ]. Driven by prior research, theory, and parsimony, a priori construct selection drove our hypothesis and aims [ 1 , 7 , 8 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 22 , 23 , 32 ]. The primary aims of this study were to examine latent profiles of (1) positive valence (PVS) and cognitive (CS) systems, ALC, and STBs among 9- to 10-year-olds in the ABCD baseline cohort and (2) examine if PVS, CS, ALC, and STB profiles prospectively predict ALC, STBs, and their co-occurrence two years after initial assessment.…”

Section: Introductionmentioning

confidence: 99%

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Application of the RDoC Framework to Predict Alcohol Use and Suicidal Thoughts and Behaviors among Early Adolescents in the Adolescent Brain and Cognitive Development (ABCD) Study

et al. 2022

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Alcohol use confers risk for suicidal thoughts and behaviors (ideation, attempt) in early adolescents. The Research Domain Criteria provides a framework for examination of multidimensional and modifiable risk factors. We examined distinct latent profiles based on patterns of positive valence (reward responsivity) and cognitive systems (neurocognition) from the ABCD Study (age 9–10, N = 10,414) at baseline enrollment. Longitudinal associations were determined between baseline positive valence and cognitive profiles and group classification (alcohol use, suicidal thoughts and behaviors, or their co-occurrence) two-years after initial assessment (ages 11–12). Three unique profiles of positive valence, cognition, alcohol use, and suicidal thoughts and behaviors were identified. Two baseline profiles predicted alcohol use and suicidal thoughts and behaviors, two-years after initial assessment. Low positive valence with high cognition (but low impulsivity) predicted alcohol use (OR = 1.414, p < 0.001), while high positive valence with low cognition (but high impulsivity) predicted suicidal thoughts and behaviors (OR = 1.25, p = 0.038), compared to average positive valence and cognition. Unique profiles of positive valence and cognitive systems among 9–12-year-olds may be predictive of alcohol use and suicidal thoughts and behaviors over a two-year period. Findings underscore the potential for trajectory research on positive valence and cognitive profiles to enhance prevention for early-adolescents.

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Associations Between Genetic Risk for Adult Suicide Attempt and Suicidal Behaviors in Young Children in the US

et al. 2022

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IMPORTANCE Suicide rates have been increasing among youth in the US. While the heritability of suicide risk is well established, there is limited understanding of how genetic risk is associated with suicidal thoughts and behaviors in young children.OBJECTIVE To examine whether genetic susceptibility to suicide attempts (SAs) is associated with suicidal thoughts and behaviors in children. DESIGN, SETTING, AND PARTICIPANTSThis case-control study examined data from the Adolescent Brain Cognitive Development (ABCD) study, a population-based longitudinal study of 11 878 US children enrolled at age 9 and 10 years from September 2016 to November 2018. Youth reports of suicidal ideation (SI) and SAs were obtained from the Kiddie Schedule for Affective Disorder and Schizophrenia at baseline and 2 subsequent years. After conservative quality control of genotype data, this analysis focused on 4344 unrelated individuals of European ancestry. Data analysis was conducted from November 2020 to February 2022. MAIN OUTCOMES AND MEASURESChildren's lifetime experiences of SI and SAs were assessed each year from ages 9 to 10 years to ages 11 to 12 years. Polygenic risk scores (PRSs) for SAs were calculated for ABCD study participants based on the largest genome-wide association study of SA cases and controls of European ancestry (total sample n = 518 612). RESULTSOf 4344 children of European ancestry (2045 [47.08%] female; mean [SD] age, 9.93 [0.62] years), significant associations were found between children's SA PRSs and their lifetime SAs with the most robust association in the follow-up year 2 (odds ratio, 1.43 [95% CI, 1.18-1.75]; corrected P = 1.85 × 10 −3 ; Nagelkerke pseudo R 2 = 1.51%). These associations remained significant after accounting for children's sociodemographic backgrounds, psychopathology symptoms, parental histories of suicide and mental health, and PRSs for major depression and attention-deficit/hyperactivity disorder (likelihood ratio test P < .05). Children's depressive mood and aggressive behavior were the most significant partial mediators of SA genetic risk on SAs (mediation analysis P < 1 × 10 −16 ). Children's behavioral problems, such as attention problems, rule-breaking behavior, and social problems, also partially mediated the association of SA PRSs with SAs (mediation analysis false discover rate < 0.05).CONCLUSIONS AND RELEVANCE This study's findings indicate that there may be genetic factors associated with SA risk across the life span and suggest behaviors and conditions through which the risk could be mediated in childhood. Further research is warranted to examine whether incorporating genetic data could improve the identification of children at risk for suicide.

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Preliminary analysis of low-level alcohol use and suicidality with children in the adolescent brain and cognitive development (ABCD) baseline cohort

Cited by 8 publications

References 67 publications

Genetic Association of Attention-Deficit/Hyperactivity Disorder and Major Depression With Suicidal Ideation and Attempts in Children: The Adolescent Brain Cognitive Development Study

Genetic Association of Attention-Deficit/Hyperactivity Disorder and Major Depression With Suicidal Ideation and Attempts in Children: The Adolescent Brain Cognitive Development Study

Application of the RDoC Framework to Predict Alcohol Use and Suicidal Thoughts and Behaviors among Early Adolescents in the Adolescent Brain and Cognitive Development (ABCD) Study

Associations Between Genetic Risk for Adult Suicide Attempt and Suicidal Behaviors in Young Children in the US

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