Preliminary analysis of stem cell-like cells in human neuroblastoma

Xing, Ling; Sha, Yong-Liang; Wu, Yeming; Hu, Jimeng; Zhang, Min; Lv, Fan

doi:10.1007/s12519-014-0529-2

Cited by 11 publications

(8 citation statements)

References 20 publications

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“…ABCG2 and nestin staining also colocalized to the same cells [ 26 ]. Both ABCG2 and nestin have since been used as markers for putative CSCs in neuroblastoma [ 25 , 28 , 29 ].…”

Section: Further Characterization Of Cscs In Neuroblastomamentioning

confidence: 99%

Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma

Garner¹,

Beierle²

2015

Cancers

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Neuroblastoma, a solid tumor arising from neural crest cells, accounts for over 15% of all pediatric cancer deaths. The interaction of neuroblastoma cancer-initiating cells with their microenvironment likely plays an integral role in the maintenance of resistant disease and tumor relapse. In this review, we discuss the interaction between neuroblastoma cancer-initiating cells and the elements of the tumor microenvironment and how these interactions may provide novel therapeutic targets for this difficult to treat disease.

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“…ABCG2 and nestin staining also colocalized to the same cells [ 26 ]. Both ABCG2 and nestin have since been used as markers for putative CSCs in neuroblastoma [ 25 , 28 , 29 ].…”

Section: Further Characterization Of Cscs In Neuroblastomamentioning

confidence: 99%

Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma

Garner¹,

Beierle²

2015

Cancers

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“…In neural stem/progenitor cells, ABCG2 and Nestin exhibits heightened colocalization and in particular the ABCG2 + and Nestin + cells mimic each other in their ability to form tumorospheres [90] . Consistently, number of studies designated them as putative CSC markers for various tumors including NB [61,91,92] . Similarly, the NB Side population cells expressing high levels of ABCG2 and ABCA3 transporter genes have been shown to possess high capabilities to expel chemotherapy drugs (e.g., mitoxantrone) and promote proliferation [16] .…”

Section: Titlementioning

confidence: 81%

Cancer stem cells in neuroblastoma therapy resistance

Aravindan¹,

Jain²,

Somasundaram³

et al. 2019

CDR

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Neuroblastoma (NB) is the most common cancer of infancy and accounts for nearly one tenth of pediatric cancer deaths. This mortality rate has been attributed to the > 50% frequency of relapse despite intensive, multimodal clinical therapy in patients with progressive NB. Given the disease's heterogeneity and developed resistance, attaining a cure after relapse of progressive NB is highly challenging. A rapid decrease in the timeline between successive recurrences is likely due to the ongoing acquisition of genetic rearrangements in undifferentiated NB-cancer stem cells (CSCs). In this review, we present the current understanding of NB-CSCs, their intrinsic role in tumorigenesis, their function in disease progression, and their influence on acquired therapy resistance and tumor evolution. In particular, this review focus on the intrinsic involvement of stem cells and signaling in the genesis of NB, the function of pre-existing CSCs in NB progression and therapy response, the formation and influence of induced CSCs (iCSCs) in drug resistance and tumor evolution, and the development of a CSC-targeted therapeutic approach.

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“…While SP represents a chemoresistant subpopulation, analysis of SP in vivo tumorigenicity and differential gene expression of NC and SA markers has yet to be elucidated. Furthermore, analysis of ABCG2 as a marker of CSCs showed ABCG2 is associated with stemness in neural stem cells and has implicated as a CSC marker; however robust evaluation of ABCG2 mediated tumorigenicity has also yet to be elucidated (Islam, et al, 2005, Xing, et al, 2015). Overall, in vivo validation of these markers as identifiers of CSC subpopulations has not be demonstrated to date.…”

Section: The Search For Neuroblastoma Cscsmentioning

confidence: 99%

“…These ALDH studies highlight the importance of rigorous in vivo testing of self-renewal rather than relying on tumorsphere re-passaging, which has been shown to be an unreliable predictor of stemness. A variety of other NB CSC markers have been used in panels, including the neurofilament Nestin, cytoplasmic protein GD2, and receptor tyrosine kinase c-KIT; however, demonstration of tumorigenicity using only in vitro models and/or expression within only a subset of NB cell lines and tumor specimens prevents the use of these proteins as robust markers (Walton, et al, 2004; Xing, et al, 2015). …”

Section: The Search For Neuroblastoma Cscsmentioning

confidence: 99%

Neuroblastoma pathogenesis: deregulation of embryonic neural crest development

2017

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Neuroblastoma (NB) is an aggressive pediatric cancer that originates from neural crest tissues of the sympathetic nervous system. NB is highly heterogeneous both from a clinical and molecular perspective. Clinically, this cancer represents a wide range of phenotypes ranging from spontaneous regression of 4S disease to unremitting treatment-refractory progression and death of high risk metastatic disease. At a cellular level, the heterogeneous behavior of NB likely arises from an arrest and deregulation of normal neural crest development. In the present review, we summarize our current knowledge of neural crest development as it relates to pathways promoting ‘stemness’ and how deregulation may contribute to the development of tumor initiating CSCs. There is an emerging consensus that such tumor subpopulations contribute to the evolution of drug resistance, metastasis, and relapse in other equally aggressive malignancies. As relapsed, refractory disease remains the primary cause of death for neuroblastoma, the identification and targeting of CSCs or other primary drivers of tumor progression remains a critical, clinically significant goal for neuroblastoma. We will critically review recent and past evidence in the literature supporting the concept of CSCs as drivers of neuroblastoma pathogenesis.

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Preliminary analysis of stem cell-like cells in human neuroblastoma

Abstract: Neuroblastoma might contain cancer stem cell-like cells.

Cited by 11 publications

References 20 publications

Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma

Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma

Cancer stem cells in neuroblastoma therapy resistance

Neuroblastoma pathogenesis: deregulation of embryonic neural crest development

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