Preliminary assessment of the risks associated with solar ultraviolet-A exposure

Petkov, Boyan; Vitale, Vito; Tomasi, Claudio; Gadaleta, Emanuela; Mazzola, Mauro; Lanconelli, Christian; Lupi, Angelo; Busetto, Maurizio; Benedetti, Elena

doi:10.1007/s00411-010-0335-8

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…They also stimulate the enzyme nitric oxide synthase that induces erythema [ 31 ], melanogenesis and contributes to immunosuppression [ 32 ]. UVB radiation also affects cutaneous angiogenesis by decreasing the expression of the thrombospondin-1 angiogenesis inhibitor by inducing the expression of vascular endothelial growth factor (VEGF, Vascular Endothelial Growth Factor) and endothelial cell growth factor 1 (ECGF1, Platelet- derived endothelial cell growth factor) [ 33 , 34 , 35 ].…”

Section: The Benefits Of Sun Exposure To Human Healthmentioning

confidence: 99%

Lipid Nanomaterials for Targeted Delivery of Dermocosmetic Ingredients: Advances in Photoprotection and Skin Anti-Aging

Souto

Jäger

et al. 2022

Nanomaterials

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Despite the health benefits of the sun, overexposure to solar radiation without proper precautions can cause irreversible damage to exposed skin. In the search for balance between the risks and benefits of exposure to solar radiation in human health, a technological alternative was found, the incorporation of photoprotective products in lipid nanoparticulate systems for topical application. These nanometric systems have demonstrated several advantages when used as adjuvants in photoprotection compared to chemical and/or physical sunscreens alone. The increase in the sun protection factor (SPF), photostability and UV action spectrum are parameters that have benefited from the application of these systems in order to increase the effectiveness and safety of photoprotective formulations containing organic and/or inorganic sunscreens.

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Section: The Benefits Of Sun Exposure To Human Healthmentioning

confidence: 99%

Lipid Nanomaterials for Targeted Delivery of Dermocosmetic Ingredients: Advances in Photoprotection and Skin Anti-Aging

Souto

Jäger

et al. 2022

Nanomaterials

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“…To enlarge the basis of protective strategy by including additional effects like previously indicated, a proper parametrization of such effects need to be performed. A similar attempt was made by Petkov et al (2011) who evaluated the exposure times ∆T UV−A,min to solar UV-A irradiance that could lead to doses D UV−A,min , which were found to trigger SCC in laboratory experiments with HaCaT keratinocytes (Colombo et al, 2017;Wischermann et al, 2008;He et al, 2006). For this purpose, weighting functions that replace the action spectrum in Eq.…”

Section: Additional Effects That Could Be Used For Protective Messagesmentioning

confidence: 99%

Some considerations on the protection against the health hazards associated with solar ultraviolet radiation

Petkov¹

2020

Preprint

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The present report briefly reviews the basic features of the current strategy for the protection against the health harms caused by solar ultraviolet (UV, ∼295 -400 nm). The emphasis has been made upon the erythema as being the best-studied UV harm and the ability of UV irradiance to damage the deoxyribonucleic acid (DNA) molecules, which leads to carcinogenesis. The erythemally weighted UV irradiance that determines the ultraviolet index (UVI), represents a common measure of the solar UV radiation level at the Earth's surface and the current protective messages have been made by using UVI as a basic parameter. However, such an approach seems insufficiently grounded to be used also in the messages against the skin cancer, bearing in mind the different nature of the erythema and DNA lesions. In this context, an enlargement of the strategy basis by including additional biological effects of UV radiation studied during the past years has been discussed. For instance, the weight of the spectral UV-A (315 -400 nm) band that in practice had been neglected by UVI definition can be enhanced since it was found to play an important role in DNA damaging. In addition, features of the contemporaneous life style can be taken into account together with some people habits.

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Procedure of embedding biological action functions into the atmospheric transmittance

Paulescu

Stefu

Gravila

et al. 2012

Theor Appl Climatol

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Preliminary assessment of the risks associated with solar ultraviolet-A exposure

Cited by 4 publications

References 37 publications

Lipid Nanomaterials for Targeted Delivery of Dermocosmetic Ingredients: Advances in Photoprotection and Skin Anti-Aging

Lipid Nanomaterials for Targeted Delivery of Dermocosmetic Ingredients: Advances in Photoprotection and Skin Anti-Aging

Some considerations on the protection against the health hazards associated with solar ultraviolet radiation

Procedure of embedding biological action functions into the atmospheric transmittance

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