Preliminary assessment of viral metagenome from cancer tissue and blood from patients with lung adenocarcinoma

Cai, Huazhong; Zhang, He-Teng; Yang, Jie; Zeng, Jian; Wang, Hao

doi:10.1002/jmv.26887

Cited by 14 publications

(9 citation statements)

References 40 publications

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“…Recent studies have indicated that global virome signatures may serve as markers of cancer development. Viral metagenomic signatures have been detected in lung adenocarcinoma biopsies (Cai et al, 2021) and more than 100 tumor samples, including oral, breast, colon, and genitourinary cancers (Mollerup et al, 2019). Cantalupo et al suggested that HPV, a known cause of cervical cancer and potentially other genitourinary cancers, is additionally correlated with tumor progression in head and neck cancers as well as bladder cancers (Cantalupo et al, 2018;IARC, 2009).…”

Section: Nonbacterial Cancer-associated Microbesmentioning

confidence: 99%

Microbiome and cancer

et al. 2021

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The human microbiome constitutes a complex multikingdom community that symbiotically interacts with the host across multiple body sites. Host-microbiome interactions impact multiple physiological processes and a variety of multifactorial disease conditions. In the past decade, microbiome communities have been suggested to influence the development, progression, metastasis formation, and treatment response of multiple cancer types. While causal evidence of microbial impacts on cancer biology is only beginning to be unraveled, enhanced molecular understanding of such cancer-modulating interactions and impacts on cancer treatment are considered of major scientific importance and clinical relevance. In this review, we describe the molecular pathogenic mechanisms shared throughout microbial niches that contribute to the initiation and progression of cancer. We highlight advances, limitations, challenges, and prospects in understanding how the microbiome may causally impact cancer and its treatment responsiveness, and how microorganisms or their secreted bioactive metabolites may be potentially harnessed and targeted as precision cancer therapeutics.

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Section: Nonbacterial Cancer-associated Microbesmentioning

confidence: 99%

Microbiome and cancer

et al. 2021

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“…Metagenomic analysis of the virome in the blood and nonsmall cell lung cancer tissues has revealed an abundant HERV presence 68 . Significantly increased levels of HERV‐K, HERV‐H, HERV‐P, and HERV‐R env mRNAs have been recognized in lung cancer tissues compared to healthy controls 69 .…”

Section: Herv Participation In Malignancies and Clinical Implicationsmentioning

confidence: 99%

“…Metagenomic analysis of the virome in the blood and nonsmall cell lung cancer tissues has revealed an abundant HERV presence. 68 Significantly increased levels of HERV‐K, HERV‐H, HERV‐P, and HERV‐R env mRNAs have been recognized in lung cancer tissues compared to healthy controls. 69 Adenocarcinoma tissues demonstrated the most prominent increases compared to other lung cancer histological types, and HERV‐K, HERV‐H, and HERV‐P levels were distinctive for lung adenocarcinoma compared to squamous and small‐cell lung cancer.…”

Section: Herv Participation In Malignancies and Clinical Implicationsmentioning

confidence: 99%

Human endogenous retroviruses in cancer: Oncogenesis mechanisms and clinical implications

Kitsou

Λάγιου

Magiorkinis

2022

Journal of Medical Virology

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Human Endogenous Retroviruses (HERVs) are viral sequences integrated into the human genome, resulting from the infection of human germ‐line cells by ancient exogenous retroviruses. Despite losing their replication and retrotransposition abilities, HERVs appear to have been co‐opted in human physiological functions while their aberrant expression is linked to human disease. The role of HERVs in multiple malignancies has been demonstrated, however, the extent to which HERV activation and expression participate in the development of cancer is not yet fully comprehended. In this review article, we discuss the presumed role of HERVs in carcinogenesis and their promising diagnostic and prognostic implications. Additionally, we explore recent data on the HERVs in cancer therapeutics, either through the manipulation of their expression, to induce antitumor innate immunity responses or as cancer immunotherapy targets. Finally, more precise and higher resolution high‐throughput sequencing approaches will further elucidate HERV participation in human physiological and pathological processes.

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“…This observation makes the scenario of a potential role of ERVs in human cancer plausible, as this is a rare form of the disease, lacking the usual exposures of this malignancy. Furthermore, metagenomic analyses in the virome of lung cancer tissues and blood from lung adenocarcinoma revealed the presence of multiple HERV families (216).…”

Section: Hervs and Human Cancer: Link Therapeutic And Prognostic Perspectivesmentioning

confidence: 99%

Viral Causality of Human Cancer and Potential Roles of Human Endogenous Retroviruses in the Multi-Omics Era: An Evolutionary Epidemiology Review

et al. 2021

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Being responsible for almost 12% of cancers worldwide, viruses are among the oldest known and most prevalent oncogenic agents. The quality of the evidence for the in vivo tumorigenic potential of microorganisms varies, thus accordingly, viruses were classified in 4 evidence-based categories by the International Agency for Research on Cancer in 2009. Since then, our understanding of the role of viruses in cancer has significantly improved, firstly due to the emergence of high throughput sequencing technologies that allowed the “brute-force” recovery of unknown viral genomes. At the same time, multi-omics approaches unravelled novel virus-host interactions in stem-cell biology. We now know that viral elements, either exogenous or endogenous, have multiple sometimes conflicting roles in human pathophysiology and the development of cancer. Here we integrate emerging evidence on viral causality in human cancer from basic mechanisms to clinical studies. We analyze viral tumorigenesis under the scope of deep-in-time human-virus evolutionary relationships and critically comment on the evidence through the eyes of clinical epidemiology, firstly by reviewing recognized oncoviruses and their mechanisms of inducing tumorigenesis, and then by examining the potential role of integrated viruses in our genome in the process of carcinogenesis.

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Preliminary assessment of viral metagenome from cancer tissue and blood from patients with lung adenocarcinoma

Cited by 14 publications

References 40 publications

Microbiome and cancer

Microbiome and cancer

Human endogenous retroviruses in cancer: Oncogenesis mechanisms and clinical implications

Viral Causality of Human Cancer and Potential Roles of Human Endogenous Retroviruses in the Multi-Omics Era: An Evolutionary Epidemiology Review

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