Preliminary characterization and potential hepatoprotective effect of polysaccharides from Cipangopaludina chinensis

Jiang, Changxing; Yun-peng, Jiao; Chen, Xiaoming; Li, Xia; Yan, Wenjun; Yu, Bo; Xiong, Qingping

doi:10.1016/j.fct.2013.05.036

Cited by 32 publications

(8 citation statements)

References 44 publications

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“…The peak at about 2930 cm −1 was ascribed to C-H stretching vibrations 18 . Moreover, the strong extensive absorption in the region of 900–1200 cm −1 for coupled C-O and C-C stretching and C-OH bending vibrations in the Al-DPS and En-DPS indicated the characteristic absorptions of polysaccharides 19 . There was a band at 1400 cm −1 due to C=O (-COOH) stretching vibration 20 .…”

Section: Resultsmentioning

confidence: 95%

“…Under normal physiological conditions, the elimination of ROS and the balance between generation and removal of ROS are performed by intracellular antioxidants to resist the oxidative damages. Whereas when the balance between generation and removal of ROS is broken, excessive accumulation of ROS will cause oxidative stress and injuries of tissues and organs 19,33 . MDA and LPO, as superfluous lipid intermediates, are capable to disturb the antioxidant defence and provide demonstrations for the pathogenic roles of oxidative stress 20 .…”

Section: Discussionmentioning

confidence: 99%

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Antihyperlipidemic and hepatoprotective properties of alkali- and enzyme-extractable polysaccharides by Dictyophora indusiata

Wang

Liu

Zhang

et al. 2019

Sci Rep

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Hyperlipidemia, a very common disease throughout the world, usually gives rise to severe liver damages. The current experiment was to investigate the antihyperlipidemic and hepatoprotective properties of alkali- and enzyme-extractable Dictyophora indusiata polysaccharides (Al-DPS and En-DPS) on the hyperlipidemic mice. The results of animal experiment in vivo showed that treatment with Al-DPS or En-DPS could improve the excessive level of lipid profiles in serum and liver, as well as strengthen antioxidant status. In addition, the histopathological observations of liver testified that polysaccharides were capable of attenuating hepatic cell injury. The primary structural features of Al-DPS and En-DPS were demonstrated by HPGPC, HPLC, FT-IR and NMR. Glucose tolerance test manifested that polysaccharides were able to restrain the rise of blood sugar. The results indicated that Al-DPS and En-DPS may be considered as novel compounds to treat hyperlipidemia and also act as hepatoprotective agents.

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Section: Resultsmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Antihyperlipidemic and hepatoprotective properties of alkali- and enzyme-extractable polysaccharides by Dictyophora indusiata

Wang

Liu

Zhang

et al. 2019

Sci Rep

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“…Recently, increasing evidence has highlighted that oxidative stress is involved in the pathogenesis and progression of hepatic injury [3,4]. Accordingly, several natural polysaccharides with antioxidant property have been demonstrated to possess potent hepatoprotective effect against various chemicals induced injury [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and protective effect of inulin and catechin grafted inulin against CCl4-induced liver injury

Liu

Lü

Wen

et al. 2015

International Journal of Biological Macromolecules

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“…[ 13 ] Plant based antioxidant compounds may have a hepatoprotective activity. [ 14 15 ] Our previous report shows antioxidant activity of ABA and it may be the reason for observed hepatoprotective action. [ 5 ] ABA also showed significant cytotoxic and apoptotic activities in HeLa cells.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective and cytotoxic activities of abietic acid from Isodon wightii (bentham) H. hara

Ramnath¹,

Thirugnanasampandan²,

Mathusalini³

et al. 2016

Phcog Res

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Isodon (Lamiaceae) is a known source of bioactive terpenoids. Diterpenoids isolated from Isodon wightii (Bentham) H. Hara showed antibacterial, antiacetylcholinesterase, antioxidant, anticancer, and anticarcinogenic activities, etc., Hepatoprotective activity of ABA against lipopolysaccharide (LPS) induced liver injury in BALB/c mice was studied. Cytotoxic activity of ABA was tested against cervical cancer cells (HeLa) using MTT assay followed by propidium iodide (PI) staining to identify apoptosis. Histopathological analysis revealed that 1.5 ॖg/mL LPS induced liver damage was attenuated by ABA in a dose dependent manner. ABA showed cytotoxicity with IC50 value of 176.28 ± 0.02 ॖg/mL and PI staining of treated cells showed apoptosis. This study proves that ABA would be a promising natural compound for herbal drug preparation.SUMMARY In the present study, abietic acid isolated from I. wightii had potent hepatoprotective effect on LPS induced liver damage in BALB/c mice. Abietic acid also showed cytotoxic activity on HeLa cells followed by apoptosis induction confirmed by PI staining. Abbreviation Used:ABA: Abietic acid; LPS: Lipopolysacharride; PBS: Phosphate buffer saline; PI: Propidium iodide; NMR: Nuclear magnetic resonance; COSY: Correlation spectroscopy; HSQC: Heteronuclear single quantum correlation; HMBC: Heteronuclear multi - bond correlation; MTT: 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide

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Preliminary characterization and potential hepatoprotective effect of polysaccharides from Cipangopaludina chinensis

Cited by 32 publications

References 44 publications

Antihyperlipidemic and hepatoprotective properties of alkali- and enzyme-extractable polysaccharides by Dictyophora indusiata

Antihyperlipidemic and hepatoprotective properties of alkali- and enzyme-extractable polysaccharides by Dictyophora indusiata

Antioxidant and protective effect of inulin and catechin grafted inulin against CCl4-induced liver injury

Hepatoprotective and cytotoxic activities of abietic acid from Isodon wightii (bentham) H. hara

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