Preliminary clinical pharmacokinetic evaluation of bemotrizinol - A new sunscreen active ingredient being considered for inclusion under FDA's over-the-counter (OTC) sunscreen monograph

D’Ruiz, Carl D.; Plautz, James; Schuetz, Rolf; Sanabria, Carlos; Hammonds, Jody; Erato, Cassandra; Klock, Jochen; Vollhardt, Juergen; Mesaros, Szilvia

doi:10.1016/j.yrtph.2023.105344

Cited by 12 publications

(5 citation statements)

References 9 publications

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“…In addition, several studies have highlighted the ability of SLN and NLC to incorporate organic UV-filters, thus supporting the feasibility of using these nanocarriers to develop sunscreen formulations [36][37][38][39].The increasing awareness of the harmful effects of both UV-A and UV-B radiation has drawn a great deal of attention to the search for broad-spectrum UV-filters that could effectively protect the skin from UV solar radiation after their topical application. In this context, bemotrizinol (BMTZ), a triazine derivative, has been designed to absorb UV radiation in the range 280-380 nm and launched in the market as a broad-spectrum sunscreen [40][41][42][43][44] In a previous work of ours, BMTZ was incorporated into various types of NLC and the technological properties of O/W emulsions containing different percentages of optimized BMTZloaded NLC were evaluated [45]. These formulations showed interesting technological characteristics, such as low BMTZ release from the vehicle, good stability and about a 20% increase of in vitro SPF values in comparison with formulations containing the same percentage of free BMTZ.…”

Section: And Nlc Have Been Extensivelymentioning

confidence: 99%

Effects of Lipid Phase Content on the Technological and Sensory Properties of O/W Emulsions Containing Bemotrizinol Loaded Nanostructured Lipid Carriers

Santonocito,

Puglia,

Montenegro

2024

Preprint

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To improve efficacy and safety of sunscreen emulsions, UV‐filter skin permeation could be kept as low as possible by reducing UV‐filter content or changing emulsion composition. In this work, different lipid phase ratio (12, 14 and 16% w/w) were assessed for their ability to affect the technological and sensory properties of O/W emulsions in which bemotrizinol (BMTZ), a broad spectrum sunscreen agent, was incorporated free or loaded into nanostructured lipid nanocarriers (NLC) to reduce its release from the vehicle and, hence, its skin permeation. The following technological properties were evaluated in vitro by suitable methodologies: spreadability, viscosity, pH, occlusion factor, BMTZ release, sun protection factor (SPF). Sensory attributes were assessed by trained panelists in three different phases: before/during pick‐up, rub‐in, after application. Raising the lipid phase ratio led to an increase of viscosity and to a corresponding drop of spreadability while the incorporation of BMTZ‐loaded NLC determined a decrease of occlusion factor and an increase of SPF. No BMTZ release was observed from all emulsions. Sensory attributes were mainly affected by lipid phase ratio. These results suggest that lipid phase ratio and BMTZ incorporation into NLC could contribute to determine technological and sensory properties of O/W emulsions.

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Section: And Nlc Have Been Extensivelymentioning

confidence: 99%

Effects of Lipid Phase Content on the Technological and Sensory Properties of O/W Emulsions Containing Bemotrizinol Loaded Nanostructured Lipid Carriers

Santonocito,

Puglia,

Montenegro

2024

Preprint

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“…In addition, another filter with a similarly broad UVA1/VL absorption spectrum, bis‐ (diethylaminohydroxybenzoyl benzoyl) piperazine (BDBP), has been approved by regulatory agencies in EU; however, it has not yet been incorporated into marketed products. Bemotrizinol (BEMT), which offers broad spectrum UVB and UVA coverage, is currently undergoing the approval process by the FDA 26 …”

Section: Sunscreen Evaluation and Classificationmentioning

confidence: 99%

“…Bemotrizinol (BEMT), which offers broad spectrum UVB and UVA coverage, is currently undergoing the approval process by the FDA. 26…”

Section: Sunscreen Evaluation and Classificationmentioning

confidence: 99%

Sunscreens—Where are we now?

Gao,

Lim,

Mohammad

2024

Dermatological Reviews

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IntroductionSunscreen serves as an important method for photoprotection, with strong evidence in minimizing photoaging, photocarcinogenesis, photodermatoses, and pigmentary disorders.ObjectiveThis review explores the legislative status of ultraviolet filters, their mechanisms of action in photoprotection, impact on human health and the environment, secondary photoprotection, and upcoming developments in photoprotection.MethodsA narrative review of recently published literature was conducted.ResultsVarious studies have raised concerns about the impact of sunscreens on the environment and personal health. Further studies are needed in particular to characterize sunscreens' impact on human health. Multiple novel forms of photoprotection are emerging to complement traditional forms of photoprotection.ConclusionsWhile the sunscreen market in the US has remained stagnant, innovations in other avenues of photoprotection are emerging.

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“…A safety and implications for the future of US sunscreens in UV filters in the United States and European Union was reviewed 7 . A maximal topical applications of 6% bis‐ethylhexyloxyphenol methoxyphenyl triazine in a model sunscreen formulation did not contribute to meaningful systemic exposure 9 . In light of the importance of the ingredients of sunscreens that affect skin problems, the choice, purchase, and satisfaction of the golf population has been identified.…”

Section: Introductionmentioning

confidence: 99%

“… 7 A maximal topical applications of 6% bis‐ethylhexyloxyphenol methoxyphenyl triazine in a model sunscreen formulation did not contribute to meaningful systemic exposure. 9 In light of the importance of the ingredients of sunscreens that affect skin problems, the choice, purchase, and satisfaction of the golf population has been identified. It is essential for sunscreens to be identified first.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of choice and satisfaction regarding the use of ultraviolet blockers in the golf population in Republic of Korea: A quantitative study

Choi,

Kwon

2023

Health Science Reports

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Background and AimsKorea's golf population surpassed 5 million (5.15 million) as of 2020 according to data analyzed by Shinhan Financial Investment in 2021. Due to the continuous increase in the golf population, it is necessary to study the use of specific sunscreens. Men and women are using sunscreen selective attributes based on the actual use and perception of sunscreens for life. A questionnaire survey was conducted for an analysis of the effect of product satisfaction.MethodsStatistical processing of materials collected by the data analysis method is analyzed using the Statistical Package for Social Science WIN 25.0 statistical package program through the process of data coding and data cleaning.ResultsThis exercise was done under 3–4 h of strong ultraviolet (UV) rays, so products that have ensured the durability of UV protection are needed. Among the demographic characteristics of the golf population, gender, age, academic background, occupation, marriage status, and monthly income were investigated, and it was confirmed that the information path of a particular product was affected by the choice of purchase, increasing satisfaction and repurchase.ConclusionAn analysis of the paper's survey showed that men's awareness and interest in sunscreens increased. It is expected that differentiated strategies will be needed for products that match the actual conditions and aptitudes of the effective golf population.

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Preliminary clinical pharmacokinetic evaluation of bemotrizinol - A new sunscreen active ingredient being considered for inclusion under FDA's over-the-counter (OTC) sunscreen monograph

Cited by 12 publications

References 9 publications

Effects of Lipid Phase Content on the Technological and Sensory Properties of O/W Emulsions Containing Bemotrizinol Loaded Nanostructured Lipid Carriers

Effects of Lipid Phase Content on the Technological and Sensory Properties of O/W Emulsions Containing Bemotrizinol Loaded Nanostructured Lipid Carriers

Sunscreens—Where are we now?

Characteristics of choice and satisfaction regarding the use of ultraviolet blockers in the golf population in Republic of Korea: A quantitative study

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