Preliminary comparative study of anti-inflammatory effect of unheated and heat-treated Sahara honey: In vivo approach

doi:10.12980/jclm.3.2015j5-139

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“…Consistent with our findings, Sahara honey, Gelam honey, Indian honey, and Yemeni Sidr honey have been previously reported to cause significant attenuation of the inflamed paw tissues of mice following carrageenan injection although with an earlier onset of around 2-4 hr pi. [30,[42][43][44] This may be attributed to the relatively higher dosage of honey (500 mg-2000 mg/kg BW vs 100 mg/kg BW) and the longer duration of treatment utilized in these studies as opposed to the present work. Nonetheless, our results indicate that PSH similarly possesses a promising anti-inflammatory activity.…”

Section: Discussionmentioning

confidence: 99%

Abrogation of Acute Inflammation in ICR Mice with Topical Administration of Philippine Stingless Bee (Tetragonula biroi Friese) Honey

Desamero¹,

Rabino²,

Tayao³

et al. 2023

Pharmacogn. Res.

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Background: Honey, a sweet sugar-rich bee-derived product, has been widely recognized in the realm of Ayurveda and Pharmacognosy for the treatment of various inflammatory conditions including inflammatory bowel disease, asthma, arthritis, and gastric ulcer. However, the anti-inflammatory effect of Philippine honey obtained from local stingless bees remains unexplored and poorly investigated. Hence, this study delved on the anti-inflammatory potential of topically applied Philippine stingless bee honey (PSH) using the λ-Carrageenan-induced mouse model of paw edema. Materials and Methods: A total of 30, male ICR mice of six weeks of age were randomly divided into the following groups (n=10 per group) as follows: Distilled water-, 1% Diclofenac sodium, and Honey-treated group. All treatments were administered immediately after Carrageenan injection and then every 8 hr during the 24-hr test duration. Results: Repeated topical application of PSH significantly attenuated the gross hind paw swelling observed at the onset of the 6 hr post-induction (pi) until the 24 hr pi with Carrageenan in contrast to the Distilled water-treated group. This corresponded histologically to a marked reduction in dermal thickness, dermal edema, and leukocytic infiltration. Whereas, at the cytokine level, this correlated to significant suppression of the circulating blood levels of pro-inflammatory cytokines, TNF-α, IL-1β, and IL-6. Conclusion: Based on these results, honey from the Philippine stingless bees shows convincing anti-inflammatory activity which is partly mediated through the regulation of the expression of inflammation-associated cytokines.

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Section: Discussionmentioning

confidence: 99%