2012
DOI: 10.1016/j.soard.2010.12.003
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Preliminary comparison of sertraline levels in postbariatric surgery patients versus matched nonsurgical cohort

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Cited by 90 publications
(80 citation statements)
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“…Interestingly, rates of any psychiatric medication usage, as well as any antidepressant medication or any antianxiety medication, remained relatively stable during the period of investigation, despite the reduced number of individuals meeting diagnostic criteria for any psychiatric disorder. Relatively little is known about clinical pharmacology after bariatric surgery, but two studies show evidence of reduced bioavailability of antidepressants after RYGB (33,34). Developing a better understanding of pharmacokinetics of psychotropic medications after surgery will inform clinical management of this patient population.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, rates of any psychiatric medication usage, as well as any antidepressant medication or any antianxiety medication, remained relatively stable during the period of investigation, despite the reduced number of individuals meeting diagnostic criteria for any psychiatric disorder. Relatively little is known about clinical pharmacology after bariatric surgery, but two studies show evidence of reduced bioavailability of antidepressants after RYGB (33,34). Developing a better understanding of pharmacokinetics of psychotropic medications after surgery will inform clinical management of this patient population.…”
Section: Discussionmentioning
confidence: 99%
“…There was a significantly smaller area under the plasma concentration/time curve in the postoperative group compared to the nonsurgical control group, which suggests an altered exposure to sertraline 63 . Despite the increasing numbers of bariatric surgeries performed, there is no accepted consensus regarding to antidepressant dosages after the different forms of bariatric surgery.…”
Section: Mood Disordersmentioning
confidence: 86%
“…Results based on such a small number of subjects cannot be generalized as most drugs display interindividual variability that must be considered as well [7]. Third, most pharmacokinetic studies have been performed in parallel patient cohorts consisting of those who had bariatric surgery a few months prior and their controls, often matched based on body mass index, age, and sex [8,9]. This design does not allow measuring the effect of surgery and weight loss for a given individual, nor the effects of other factors of interindividual variability of drug disposition, such as drug metabolism phenotypes.…”
Section: Weaknesses In the Research Done In This Fieldmentioning
confidence: 99%