Preliminary Data on Some Behavioral Changes Induced by Short-Term Intraperitoneal Oxytocin Administration in Aged Rats

Balmus, Ioana Miruna; Lefter, Radu; Ciobîcă, Alin; Antioch, Iulia; Ababei, Daniela Carmen; Dobrin, Romeo

doi:10.24869/psyd.2018.91

Cited by 9 publications

(5 citation statements)

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“…It is well known that SD induces a clear anxiogenic effect (Albrechet-Souza et al, 2017;Macedo et al, 2018), which is completely blocked by OXT administration. Although data are controversial (for example, Grippo et al, 2012), many studies indicate that OXT exerts an anxiolytic effect in both sexes and even in aged rats (Balmus et al, 2018;Waldherr and Neumann, 2007). However, we did not observe any OXT effect on non-stressed mice.…”

Section: Discussioncontrasting

confidence: 81%

Oxytocin prevents the increase of cocaine-related responses produced by social defeat

et al. 2019

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Section: Discussioncontrasting

confidence: 81%

Oxytocin prevents the increase of cocaine-related responses produced by social defeat

et al. 2019

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“…OXT treatment began at PND90 when rats reached an average weight of 150 g. OXT (Sigma-Aldrich Co., LLC., Darmstadt, Germany) was intraperitoneally injected in the IP OXT-VPA group in a dose of 10 mg/kg/bodyweight for 8 days consecutively. This dosage was established based on previous published work of our group [ 54 , 55 ] and others [ 56 ]. Behavioral tests were initiated on the 6th day of OXT treatment and lasted three days during which the OXT administration continued.…”

Section: Methodsmentioning

confidence: 99%

Oxytocin Differentiated Effects According to the Administration Route in a Prenatal Valproic Acid-Induced Rat Model of Autism

et al. 2020

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Background and objectives: The hormone oxytocin (OXT) has already been reported in both human and animal studies for its promising therapeutic potential in autism spectrum disorder (ASD), but the comparative effectiveness of various administration routes, whether central or peripheral has been insufficiently studied. In the present study, we examined the effects of intranasal (IN) vs. intraperitoneal (IP) oxytocin in a valproic-acid (VPA) autistic rat model, focusing on cognitive and mood behavioral disturbances, gastrointestinal transit and central oxidative stress status. Materials and Methods: VPA prenatally-exposed rats (500 mg/kg; age 90 days) in small groups of 5 (n = 20 total) were given OXT by IP injection (10 mg/kg) for 8 days consecutively or by an adapted IN pipetting protocol (12 IU/kg, 20 μL/day) for 4 consecutive days. Behavioral tests were performed during the last three days of OXT treatment, and OXT was administrated 20 minutes before each behavioral testing for each rat. Biochemical determination of oxidative stress markers in the temporal area included superoxide dismutase (SOD), glutathione peroxidase (GPx) and malondialdehyde (MDA). A brief quantitative assessment of fecal discharge over a period of 24 hours was performed at the end of the OXT treatment to determine differences in intestinal transit. Results: OXT improved behavioral and oxidative stress status in both routes of administration, but IN treatment had significantly better outcome in improving short-term memory, alleviating depressive manifestations and mitigating lipid peroxidation in the temporal lobes. Significant correlations were also found between behavioral parameters and oxidative stress status in rats after OXT administration. The quantitative evaluation of the gastrointestinal (GI) transit indicated lower fecal pellet counts in the VPA group and homogenous average values for the control and both OXT treated groups. Conclusions: The data from the present study suggest OXT IN administration to be more efficient than IP injections in alleviating autistic cognitive and mood dysfunctions in a VPA-induced rat model. OXT effects on the cognitive and mood behavior of autistic rats may be associated with its effects on oxidative stress. Additionally, present results provide preliminary evidence that OXT may have a balancing effect on gastrointestinal motility.

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“…Y-Maze Task . For assessing short-term memory modifications, we used the reliable Y-maze task, as described in a previous study [52]. The spontaneous alternation percentage, defined by the consecutive entries into all three arms of the maze, was analyzed as the behavioral marker to reflect spatial working memory.…”

Section: Methodsmentioning

confidence: 99%

“…Elevated Plus Maze Task (EPM) . Anxiety-like behavior was assessed in the EPM paradigm which was also described in our previous study from 2018 [52]. Rats were placed at the juncture of the open and closed arms, and the amount of time spent on the open arms was recorded during a 5 min test.…”

Section: Methodsmentioning

confidence: 99%

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Antioxidant Capacity and Behavioral Relevance of a Polyphenolic Extract of Chrysanthellum americanum in a Rat Model of Irritable Bowel Syndrome

Cojocariu

Ciobîcă

Balmuș

et al. 2019

Oxidative Medicine and Cellular Longevity

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Chrysanthellum americanum L. (Vatke) is a medicinal plant from the Compositae family used in west-African traditional medicine, known for its flavonoid and saponin richness and for its strong antioxidant potential. In the present study, we assessed the effects of Chrysanthellum americanum polyphenolic extract in the psychological stress-induced rat model of irritable bowel syndrome (IBS), a chronic functional digestive tract disorder marked by immune and inflammatory-related disturbances of central nervous and peripheral intestinal systems, which is often associated with mood disorders including depression and anxiety. Consequently, memory impairment, anxiety and depression behavioral indicators, and cerebral oxidative stress biomarker dynamics were evaluated in a multifactorial heterotypic stress-exposed IBS rats after 6-day gavage with polyphenolic C. americanum extract (100 mg/kg body weight). Y-maze, elevated plus maze, and forced swimming tests were used for assessing behavioral responses. Administration of the extract exhibited significant anxiolytic and antidepressant-like effects coupled with significantly increased temporal lobe antioxidant enzyme specific activity (superoxide dismutase and glutathione peroxidase) and decreased malondialdehyde levels, a well-known lipid peroxidation marker. Furthermore, linear regression statistical analyses showed significant correlations between the oxidative stress parameters and behavioral tests. In conclusion, our results suggest that the administration of Chrysanthellum americanum polyphenolic extract could ameliorate mood and cognitive disturbances related to stress-induced in an IBS rat model. This could be also related to cerebral oxidative stress status attenuation.

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Preliminary Data on Some Behavioral Changes Induced by Short-Term Intraperitoneal Oxytocin Administration in Aged Rats

Cited by 9 publications

References 31 publications

Oxytocin prevents the increase of cocaine-related responses produced by social defeat

Oxytocin prevents the increase of cocaine-related responses produced by social defeat

Oxytocin Differentiated Effects According to the Administration Route in a Prenatal Valproic Acid-Induced Rat Model of Autism

Antioxidant Capacity and Behavioral Relevance of a Polyphenolic Extract of Chrysanthellum americanum in a Rat Model of Irritable Bowel Syndrome

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