As part of newly developing aviation markets, fixed-wing Uncrewed Aircraft Systems (UAS) are projected to impact airspace systems and conventional air traffic in the future. The initial introduction of fixed-wing cargo UAS for regional operations is anticipated to occur at smaller underutilized airports. Therefore, this paper assesses the integration potential of regional fixed-wing cargo UAS into the airspace system. A baseline is established to identify potential airports for UAS operations in different areas. Additionally, using 2022 data, regional aircraft eligible for future cargo UAS operations are investigated. Finally, the accessibility of these regional aircraft at the identified airports was analyzed. Based on the availability of current certified landing systems needed for initial UAS operations, the potential airports for UAS operations are compared in the areas of Germany, Texas, and California. Despite 173 identified airports for potential UAS operations in Germany, 376 in Texas, and 231 in California, only eleven of these airports provide current certified landing systems needed for initial UAS operations. However, other landing system technologies that are currently under development, such as vision-based landing systems, might support UAS accessibility at the identified airports for potential UAS operations in the future.