2016
DOI: 10.1097/mat.0000000000000311
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Preliminary Diffusive Clearance of Silicon Nanopore Membranes in a Parallel Plate Configuration for Renal Replacement Therapy

Abstract: Silicon nanopore membranes (SNM) with compact geometry and uniform pore size distribution have demonstrated a remarkable capacity for hemofiltration. These advantages could potentially be used for hemodialysis. Here we present an initial evaluation of the SNM’s mechanical robustness, diffusive clearance, and hemocompatibility in a parallel plate configuration. Mechanical robustness of the SNM was demonstrated by exposing membranes to high flows (200ml/min) and pressures (1,448mmHg). Diffusive clearance was per… Show more

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Cited by 7 publications
(7 citation statements)
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“…Tunneled catheters were placed in the carotid artery and jugular vein of a 55 kg Yorkshire female pig, and a closed external circuitry was set up. A custom designed, flow path optimized titanium housing containing separated blood flow chambers, 58 each holding 18 1 Â 1 cm 2 solid pSBMA-silicon chips was utilized for ex vivo blood flow experiments. Blood flowed from the carotid artery through Masterfelx, Tygon E-LFL Tubing (L/S 25, 4.8 mm inner diameter from Cole-Parmer) to the extracorporeal device, then back through Tygon tubing to the catheter connected to the jugular vein.…”
Section: Extracorporeal Studymentioning
confidence: 99%
“…Tunneled catheters were placed in the carotid artery and jugular vein of a 55 kg Yorkshire female pig, and a closed external circuitry was set up. A custom designed, flow path optimized titanium housing containing separated blood flow chambers, 58 each holding 18 1 Â 1 cm 2 solid pSBMA-silicon chips was utilized for ex vivo blood flow experiments. Blood flowed from the carotid artery through Masterfelx, Tygon E-LFL Tubing (L/S 25, 4.8 mm inner diameter from Cole-Parmer) to the extracorporeal device, then back through Tygon tubing to the catheter connected to the jugular vein.…”
Section: Extracorporeal Studymentioning
confidence: 99%
“…The fabrication of the SμM‐PDMS membrane is based on prior work in this lab on silicon nanopore membranes, with adaptations specific to this project . Briefly, the prior work describes a process by which controlled growth of silicon dioxide produces arrays of sub‐100 nm rectangular pores within silicon wafers (Fig.…”
Section: Methodsmentioning
confidence: 99%
“…The hemofiltration unit is constructed from biocompatible silicon nanopore membranes, which exhibit high flux and high selectivity such that cardiac perfusion pressure is sufficient enough to drive blood flow without need for battery or electrical power. Various components of the implantable artificial kidney are being evaluated via a series of preclinical studies (18,(49)(50)(51)(52)(53). Membranes configured in a parallel-plate hemofilter format were implanted in six dogs that received only antithrombotic therapy (acetylsalicylic acid) (18).…”
Section: Implantable Kidney Replacement Therapymentioning
confidence: 99%