Preliminary dosimetric evaluation of 166 Ho-TTHMP for human based on biodistribution data in rats

Yousefnia, Hassan; Zolghadri, Samaneh; Jalilian, Amir Reza; Tajik, M.; Ghannadi‐Maragheh, Mohammad

doi:10.1016/j.apradiso.2014.08.017

Cited by 19 publications

(12 citation statements)

References 14 publications

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“…Extrapolation between animal data to human may lead to some over- or underestimation, previous studies have indicated the usefulness of using animal biodistribution as a model for absorbed dose estimations in humans. [ 23 ]…”

Section: Discussionmentioning

confidence: 99%

Absorbed dose assessment of ¹⁷⁷ Lu-zoledronate and ¹⁷⁷ Lu-EDTMP for human based on biodistribution data in rats

Yousefnia¹,

Zolghadri²,

Jalilian³

2015

J Med Phys

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Over the past few decades, several bone-seeking radiopharmaceuticals including various bisphosphonate ligands and β-emitting radionuclides have been developed for bone pain palliation. Recently, 177Lu was successfully labeled with zoledronic acid (177Lu-ZLD) as a new generation potential bisphosphonate and demonstrated significant accumulation in bone tissue. In this work, the absorbed dose to each organ of human for 177Lu-ZLD and 177Lu-ethylenediaminetetramethylene phosphonic acid (177Lu-EDTMP;as the only clinically bone pain palliation agent) was investigated based on biodistribution data in rats by medical internal radiation dosimetry (MIRD) method. 177Lu-ZLD and 177Lu-EDTMP were prepared in high radiochemical purity (>99%, instant thin layer chromatography (ITLC)) at the optimized condition. The biodistribution of the complexes demonstrated fast blood clearance and major accumulation in the bone tissue. The highest absorbed dose for both 177Lu-ZLD and 177Lu-EDTMP is observed in trabecular bone surface with 12.173 and 10.019 mSv/MBq, respectively. The results showed that 177Lu-ZLD has better characteristics compared to 177Lu-EDTMP and can be a good candidate for bone pain palliation.

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Section: Discussionmentioning

confidence: 99%

Absorbed dose assessment of ¹⁷⁷ Lu-zoledronate and ¹⁷⁷ Lu-EDTMP for human based on biodistribution data in rats

Yousefnia¹,

Zolghadri²,

Jalilian³

2015

J Med Phys

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“…Rex and Regina were centered at the origin (0,0,0) and inserted in a 5‐m radius air sphere. The biodistributed percentage of the radionuclides inside each organ of the phantom was considered in the simulations, from the data found in the literature . Every radionuclide was simulated individually by using the voxel phantoms where the most significant organs were considered as sources with the radionuclide of interest, following the necessary biodistribution mentioned above.…”

Section: Methodsmentioning

confidence: 99%

Determination of the dose rate constant through Monte Carlo simulations with voxel phantoms

2018

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The results for the body dose rate constant calculated in this work, for 30 radionuclides and 57 radiopharmaceuticals, and their effective half-lives, may be used to estimate the dose emitted by a person who has incorporated a radionuclide in the Nuclear Medicine activity range. This dose will be optimized when the body dose rate constant and the effective half-life determined in this study are used together with dose reduction factors.

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“…The accumulated activity for each organ of animals was extrapolated to human according to the mean weights of each organ of human and rat given in Table 1. The mean weight of the organs gathered from the animals and standard weights established for the adult male human organs was used [15].…”

Section: Dosimetric Calculationsmentioning

confidence: 99%

Determination of human absorbed dose of cocktail of 153Sm/177Lu-EDTMP, based on biodistribution data in rats

Ranjbar¹,

Bahrami-Samani²,

Yazdani

et al. 2015

J Radioanal Nucl Chem

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The aim of this work was to estimate the absorbed dose due to compositional radiopharmaceutical of 153 Sm/ 177 Lu-EDTMP in human organs based on biodistribution data of rats by using OLINDA/EXM software. The absorbed dose was determined by the Radiation Dose Assessment Resource (RADAR) formulation after calculating cumulated activities in each organ. The results show that the organs that received the highest absorbed dose were the bone surface and red marrow (1.51 and 7.99 mGy/ MBq for 153 Sm, and 1.98 and 10.76 mGy/MBq for 177 Lu, respectively). According to the results, using of cocktail of 153 Sm/ 177 Lu-EDTMP has considerable characteristics as compared to 153 Sm-EDTMP and 177 Lu-EDTMP alone.

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Preliminary dosimetric evaluation of 166 Ho-TTHMP for human based on biodistribution data in rats

Cited by 19 publications

References 14 publications

Absorbed dose assessment of ¹⁷⁷ Lu-zoledronate and ¹⁷⁷ Lu-EDTMP for human based on biodistribution data in rats

Absorbed dose assessment of ¹⁷⁷ Lu-zoledronate and ¹⁷⁷ Lu-EDTMP for human based on biodistribution data in rats

Determination of the dose rate constant through Monte Carlo simulations with voxel phantoms

Determination of human absorbed dose of cocktail of 153Sm/177Lu-EDTMP, based on biodistribution data in rats

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Preliminary dosimetric evaluation of 166 Ho-TTHMP for human based on biodistribution data in rats

Cited by 19 publications

References 14 publications

Absorbed dose assessment of 177 Lu-zoledronate and 177 Lu-EDTMP for human based on biodistribution data in rats

Absorbed dose assessment of 177 Lu-zoledronate and 177 Lu-EDTMP for human based on biodistribution data in rats

Determination of the dose rate constant through Monte Carlo simulations with voxel phantoms

Determination of human absorbed dose of cocktail of 153Sm/177Lu-EDTMP, based on biodistribution data in rats

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Absorbed dose assessment of ¹⁷⁷ Lu-zoledronate and ¹⁷⁷ Lu-EDTMP for human based on biodistribution data in rats

Absorbed dose assessment of ¹⁷⁷ Lu-zoledronate and ¹⁷⁷ Lu-EDTMP for human based on biodistribution data in rats