Preliminary Evaluation of Biological Activities and Phytochemical Analysis of Syngonium podophyllum Leaf

Kumar, Shashank; Dwivedi, Astha; Kumar, Ramesh; Pandey, Abhay K.

doi:10.1007/s40009-014-0318-4

Cited by 10 publications

(5 citation statements)

References 14 publications

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“…Many plant products, namely, cinnamon, clove, jambolan, pomegranate, thyme, and lantana extracts have been shown to inhibit the growth of multidrug resistant Pseudomonas aeruginosa . There is a need to search for new antimicrobial substances from natural sources and to develop new infection-fighting strategies to control microbial infections [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

In VitroAntioxidant, Antibacterial, and Cytotoxic Activity andIn VivoEffect ofSyngonium podophyllumandEichhornia crassipesLeaf Extracts on Isoniazid Induced Oxidative Stress and Hepatic Markers

Kumar

Dwivedi

et al. 2014

BioMed Research International

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The present study reports the in vitro antioxidant, antibacterial, and cytotoxic potential of Syngonium podophyllum (SP) and Eichhornia crassipes (EC) leaf aqueous extracts as well as their in vivo effect on oxidative stress and hepatic biomarkers in isoniazid induced rats. Phytochemical screening of extracts revealed the presence of flavonoids, terpenoids, reducing sugars, alkaloids, and saponins. Phenolic content in SP and EC extracts was 5.36 ± 0.32 and 10.63 ± 0.13 mg PGE/g, respectively, while flavonoid content was 1.26 ± 0.03 and 0.51 ± 0.03 μg QE/mg, respectively. EC extract exhibited comparatively better antioxidant activity as indicated by reducing power (0.197–0.775), DPPH radical scavenging potential (11%–96%), and metal ion chelating ability (42%–93%). Both the extracts provided 13%–65% protection against lipid peroxidation in rat tissue (liver, kidney, and brain) homogenate. SP and EC extracts exhibited 51% and 43% cytotoxicity against lung cancer (NCI-H322) cell line, respectively. Both extracts demonstrated considerable antibacterial activity against Proteus vulgaris, Salmonella typhi, and Bordetella bronchiseptica. Coadministration of E. crassipes extract with isoniazid in rats accounted for 46% decrease in malondialdehyde content and 21% increase in FRAP value of plasma. It also mitigated the isoniazid induced alterations in serum enzymes (SGOT, SGPT, and ALP), total bilirubin, creatinine, and hemoglobin contents. S. podophyllum extract was found to be hepatotoxic.

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Section: Introductionmentioning

confidence: 99%

In VitroAntioxidant, Antibacterial, and Cytotoxic Activity andIn VivoEffect ofSyngonium podophyllumandEichhornia crassipesLeaf Extracts on Isoniazid Induced Oxidative Stress and Hepatic Markers

Kumar

Dwivedi

et al. 2014

BioMed Research International

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“…Moreover, the fact that Syngonium produces phenols was first observed by Lynn Miller and Toshio Murashige [22]. These observations were later confirmed by several teams of scientists, proving that this ornamental species also has a high therapeutic value-mainly due to phenolic compounds with high antioxidant activity [27][28][29]. Later, in 2001, Jose Carlos Lorenzo et al proved that the addition of cysteine shoot formation and the excretion of phenols in the in vitro cultivation of sugarca These authors also acknowledged several examples that showed contrasting resu velopmental processes for other species and in vitro systems.…”

Section: Effects Of Cysteine On Callus Formation In N69 Mediummentioning

confidence: 81%

“…The increase in commercial demand worldwide creates the opportunity for this species to be studied and introduced for industrial micropropagation [25] and, furthermore, to be considered one of the most valuable indoor ornamental plants in the world [26]. Moreover, today, it is known that syngonium is also a source of valuable phenolic compounds with different potential uses in medicine [27][28][29]. Generally, a major consequence of intense trade is to facilitate the spread of species to new environments.…”

Section: Introductionmentioning

confidence: 99%

“…In the case of leaf fragments, 2,4-D induced a 2.45-fold increase in TPA activity compared to intact leaves and a 1.25-fold increase compared to the control leaf fragments. Due to the larger leaf surface for wounding, the release of phenolic compounds [27][28][29] might have been responsible for the activation of enzymes with peroxidase activity, which should greatly enhance the wound stress response of leaf fragments in the presence of 2,4-D.…”

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confidence: 99%

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De Novo Shoot Development of Tropical Plants: New Insights for Syngonium podophyllum Schott.

Sand

Antofie

2022

Horticulturae

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Syngonium podophyllum Schott. cv. ‘White Butterfly’ is recognized as a valuable ornamental plant, and today it is also an important plant species of medicinal interest due to its high contents of phenolic compounds. The purpose of this article is to review the main scientific publications from our laboratory with regard to new scientific achievements dealing with Syngonium species or topics of interest, such as callus formation and further de novo shoot regeneration. The principles and stages necessary to start an industrial-level micropropagation protocol are discussed based on our experience. Different media compositions induced different morphogenetic responses inside the callus—particularly those related to the development of xylematic elements in the organogenetic areas, such as those for rooting, protocorms, and de novo shoot formation. The re-evaluation of old histological images revealed for the first time that xylematic elements are constantly closely positioned to all organogenetic centers, and that their development is closely dependent on the composition of the culture medium. Separate protocorms can be identified only when xylematic tracheary elements are well developed and closely connected to them. The formation of protocorms is strongly dependent on the mineral composition of the culture medium and the balance of plant growth regulators.

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“…Thus, reduced GSH content in fluoxetine-treated rats could be responsible for an increase in lipid peroxidation. Elevated levels of MDA, a product of lipid peroxidation, in the tissue also signify the oxidized state of the system that is beyond the control of the antioxidant defense system[ 44 - 48 ]. The higher levels of AOPP also point towards oxidative stress causing protein damage following prolonged fluoxetine treatment in rats.…”

Section: Discussionmentioning

confidence: 99%

Baicalin provides protection against fluoxetine-induced hepatotoxicity by modulation of oxidative stress and inflammation

Ganguly¹,

Kumar²,

Pandey³

2022

WJH

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BACKGROUND Fluoxetine is one of the most widely prescribed anti-depressant drugs belonging to the category of selective serotonin reuptake inhibitors. Long-term fluoxetine treatment results in hepatotoxicity. Baicalin, a natural compound obtained from the Chinese herb Scutellaria baicalensis is known to have antioxidant, hepatoprotective and anti-inflammatory effects. However, the beneficial effects of baicalin against fluoxetine-induced hepatic damage have not previously been reported. AIM To evaluate the protective action of baicalin in fluoxetine-induced liver toxicity and inflammation. METHODS Male albino Wistar rats were divided into seven groups. Group 1 was the normal control. Oral fluoxetine was administered at 10 mg/kg body weight to groups 2, 3, 4 and 5. In addition, groups 3 and 4 were also co-administered oral baicalin (50 mg/kg and 100 mg/kg, respectively) while group 5 received silymarin (100 mg/kg), a standard hepatoprotective compound for comparison. Groups 6 and 7 were used as a positive control for baicalin (100 mg/kg) and silymarin (100 mg/kg), respectively. All treatments were carried out for 28 d. After sacrifice of the rats, biomarkers of oxidative stress [superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione-S-transferase (GST), advanced oxidation protein products (AOPP), malondialdehyde (MDA)], and liver injury [alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total protein, albumin, bilirubin] were studied in serum and tissue using standard protocols and diagnostic kits. Inflammatory markers [tumor necrosis factor (TNF-α), interleukin (IL)-6, IL-10 and interferon (IFN)-γ] in serum were evaluated using ELISA-based kits. The effect of baicalin on liver was also analyzed by histopathological examination of tissue sections. RESULTS Fluoxetine-treated rats showed elevated levels of the serum liver function markers (total bilirubin, ALT, AST, and ALP) and inflammatory markers (TNF-α, IL-6, IL-10 and IFN-γ), with a decline in total protein and albumin levels. Biochemical markers of oxidative stress such as SOD, CAT, GST, GSH, MDA and AOPP in the liver tissue homogenate were also altered indicating a surge in reactive oxygen species leading to oxidative damage. Histological examination of liver tissue also showed degeneration of hepatocytes. Concurrent administration of baicalin (50 and 100 mg/kg) restored the biomarkers of oxidative stress, inflammation and hepatic damage in serum as well as in liver tissues to near normal levels. CONCLUSION These findings suggested that long-term treatment with fluoxetine leads to oxidative stress via the formation of free radicals that consequently cause inflammation and liver damage. Concurrent treatment with baicalin alleviated fluoxetine-induced hepatotoxicity and liver injury by regulating oxidative stress a...

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Preliminary Evaluation of Biological Activities and Phytochemical Analysis of Syngonium podophyllum Leaf

Cited by 10 publications

References 14 publications

In VitroAntioxidant, Antibacterial, and Cytotoxic Activity andIn VivoEffect ofSyngonium podophyllumandEichhornia crassipesLeaf Extracts on Isoniazid Induced Oxidative Stress and Hepatic Markers

In VitroAntioxidant, Antibacterial, and Cytotoxic Activity andIn VivoEffect ofSyngonium podophyllumandEichhornia crassipesLeaf Extracts on Isoniazid Induced Oxidative Stress and Hepatic Markers

De Novo Shoot Development of Tropical Plants: New Insights for Syngonium podophyllum Schott.

Baicalin provides protection against fluoxetine-induced hepatotoxicity by modulation of oxidative stress and inflammation

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