Preliminary evaluation of dual wavelength phased array imaging on neonatal brain function

Chen, Yu; Zhou, Shaosheng; Xie, Chunhua; Nioka, Shoko; Delivoria‐Papadopoulos, Maria; Anday, Endla K.; Chance, Britton

doi:10.1117/1.429986

Cited by 15 publications

(8 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…OT has been also used to study spontaneous changes in oxygenation of the cortex of sleeping infants (23). Other researchers have proposed different techniques by using NIR lights to obtain functional brain imaging of passive motor response in preterm and term infants (24,25). In the present study, we used OT to obtain functional brain images of awake infants when exposed to visual stimuli.…”

mentioning

confidence: 99%

Brain imaging in awake infants by near-infrared optical topography

Taga

Asakawa

Maki

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

267

201

View full text Add to dashboard Cite

Studies of young infants are critical to understand perceptual, motor, and cognitive processing in humans. However, brain mechanisms involved are poorly understood, because the use of brainimaging methods such as functional magnetic resonance imaging in awake infants is difficult. In the present study we show functional brain imaging of awake infants viewing visual stimuli by means of multichannel near-infrared spectroscopy, a technique that permits a measurement of cerebral hemoglobin oxygenation in response to brain activation through the intact skull without subject constraint. We found that event-related increases in oxyhemoglobin were evident in localized areas of the occipital cortex of infants aged 2-4 months in response to a brief presentation of a checkerboard pattern reversal while they maintained fixation to attention-grabbing stimuli. The dynamic change in cerebral blood oxygenation was qualitatively similar to that observed in the adult brain. This result introduces near-infrared optical topography as a method for investigating the functional development of the brain in early infancy.

show abstract

mentioning

confidence: 99%

Brain imaging in awake infants by near-infrared optical topography

Taga

Asakawa

Maki

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

267

201

View full text Add to dashboard Cite

show abstract

“…The NIRS technique used in the present research utilizes changes in blood volume and hemoglobin oxygenation (i.e., hemodynamics) as an index of neural activation (see Meek, 2002;Grinvald et al, 1991;Strangman et al, 2002a;Villringer and Chance, 1997;Villringer and Dirnagl, 1995). This technique has been used with medically at-risk infants in the clinical setting (Chen et al, 2000;Hintz et al, 2001;Meek et al, 1999b;Meek et al, 1998;Meek et al, 1999a;Sakatani et al, 1999;Soul and du Plessis, 1999;Zaramella et al, 2001) and, more recently, its applicability in the experimental setting has been explored (Baird et al, 2002;Peña et al, 2003); Taga et al, 2003;Wilcox et al, 2005). The rationale for this approach rests on the concept that neural activation in response to a stimulus results in increased energy demands in the area activated.…”

mentioning

confidence: 99%

Assessing infants' cortical response to speech using near-infrared spectroscopy

2007

View full text Add to dashboard Cite

Sensitivity to spoken language is an integral part of infants' formative development, yet relatively little is known about the neural mechanisms that underlie the emerging ability to perceive and process speech. This is in large part because there are a limited number of non-invasive techniques available to measure brain functioning in human infants. Near-infrared spectroscopy (NIRS), an optical imaging technique that estimates changes in neuronal activity by measuring changes in total hemoglobin concentration and oxygenation, may be a viable procedure for assessing the relation between speech processing and brain function in human infants. While auditory processing data have been gathered from newborn and preterm infants using NIRS, such data have not been collected from older infants. Many behavioral measures used to establish linguistic sensitivity in this population are accompanied by visual stimuli; however, it is unclear how coupling of auditory and visual stimuli influences neural processing. Here we studied cortical activity in infants aged 6-9 months, as measured by NIRS, during exposure to linguistic stimuli paired with visual stimuli and compared this to the activity observed in the same regions during exposure to visual stimuli alone. Results dissociate infants' hemodynamic responses to multimodal and unimodal stimuli, demonstrating the utility of NIRS for studying perceptual development in infants. In particular, these findings support the utility of NIRS for studying the neurobiology of language development in older infants, a task that is difficult to accomplish without the use of attention-getting visual stimuli.Infants' ability to perceive speech begins in the womb, and progresses dramatically during the first year of life (DeCasper and Fifer, 1980;Werker and Tees, 1984). Research indicates that during the last trimester in-utero (Mehler et al., 1988), and in the first twelve months of life post-natally (Jusczyk, 1997), infants become aware of and adjust to regularities in their native language. By using various cues found in adult speech, infants gradually come to understand and use their native language. For example, between 6 and 9 months of age, infants become sensitive to patterns within their native language, such as prosodic cues (Cutler, 1990;Morgan, 1996), phonotactic cues (Hohne and Jusczyk, 1994;Jusczyk et al., 1994), and allophonic variation (Hohne and Jusczyk, 1994). Investigating and understanding the mechanisms of the trajectory of such advances is a difficult task, and researchers have advanced the study of infant speech perception largely based on clever behavioral paradigms (e.g., Eimas et al., 1971;Trehub, 1973;Jusczyk et al., 1993;Saffran et al., 1996).The behavioral methods used to understand language development across infants' first year are typically chosen based on the specific age group being studied and the particular question being asked. For example, with infants four months of age and younger, a useful method employs a pacifier to record changes in infant su...

show abstract

“…5 The maturation of this response seems to depend on the type of stimulus and the state of wakefulness of the infant as well as their age, and it is currently an area of active research using optical topography. [6][7][8][9][10] Bartocci et al investigated the response to olfactory stimuli in the newborn: they found a significant increase in oxyhaemoglobin measured over the frontal cortex in response to colostrum which was inversely related to postnatal age. 11 Neonates were also able to differentiate between pleasant and unpleasant odours.…”

Section: Functional Nirsmentioning

confidence: 99%

Optical imaging of the neonatal brain

Austin

2007

Archives of Disease in Childhood - Fetal and Neonatal Edition

View full text Add to dashboard Cite

Preliminary evaluation of dual wavelength phased array imaging on neonatal brain function

Cited by 15 publications

References 20 publications

Brain imaging in awake infants by near-infrared optical topography

Brain imaging in awake infants by near-infrared optical topography

Assessing infants' cortical response to speech using near-infrared spectroscopy

Optical imaging of the neonatal brain

Contact Info

Product

Resources

About