Evaluation of the spatial distribution of urban emergency shelters can effectively identify defects in the current distribution of urban emergency shelters and weaknesses in the overall evacuation service capacity of the city and provide reference for improving the level of urban emergency shelters and evacuation and disaster relief capacity. At present, evaluation of the spatial distribution of urban emergency shelters is mainly carried out on three aspects: effectiveness, accessibility, and safety. However, there are problems, such as individual evaluation scales and incomplete indicator systems, unreasonable allocation of indicator weights, and ignoring the influence of fuzzy incompatibility between different indicator attributes on the evaluation results. In this paper, we start from two scales, the individual emergency shelter and the regional groups of emergency shelters. Based on the five criteria of effectiveness, accessibility, safety, suitability, and fairness, the evaluation indicator system of the spatial distribution of urban emergency shelters was constructed. It was combined with AHP, CRITIC, the optimal weight coefficient solution method based on the maximum deviation sum of squares theory, and fuzzy optimization theory to construct a multi-indicator evaluation model. Further, the spatial distribution condition of the existing emergency shelter in Shanghai was evaluated. The results show that: among the existing ninety-one emergency shelters in Shanghai, there are nine places with unreasonable spatial distribution; nineteen places are comparatively unreasonable. From the scale of regional groups, there is one district (Pudong New District) with unreasonable spatial distribution: its relative superiority value is far lower than other districts, and there are three districts that are comparatively unreasonable. Further, the evaluation scores of the spatial distribution reasonableness of emergency shelters in each region of Shanghai show a high–low–middle distribution from the downtown area of Shanghai outward. The evaluation indicator system and evaluation method used in this paper can effectively reflect the deficiencies in the spatial distribution of urban emergency shelters, thus providing a reference for the relevant departments to improve and plan emergency shelters.