Preliminary evaluation of human health risks from ingestion of organotin contamined seafood in Brazil

Fernandez, Marcos Antônio; Limaverde, Aricelso Maia; Scofield, Arthur de L.; Wagener, Ângela de Luca Rebello

doi:10.1590/s1679-87592005000100008

Cited by 13 publications

(9 citation statements)

References 11 publications

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“…However, little of this research has extended the seafood contamination model to the toxicology of OTs, and an even smaller subset has focused on reproductive toxicology. Several investigations have reported a possible health risk in the consumption of seafood containing OTs [44,45,66]. Available information on OTs deposition in humans or mammals, based on a few studies in Japanese, Polish or Danish populations, is limited [18,48,67].…”

Section: Discussionmentioning

confidence: 99%

“…The oral route of exposure was chosen based on previous studies [3,24,[53][54][55][56]. Using OTs accumulated in seafood enabled us to compare our results with previous work on OTs and allowed us to compare the effects of OTs present in seafood, which has strongly toxic properties as one of its potential mechanisms [44,45]. OTs accumulated in seafood are not a pure OTs; therefore, the use of seafood without OTs also enabled us to differentiate toxic from non-toxic effects.…”

Section: Experimental Animals and Treatmentsmentioning

confidence: 99%

“…Also, in order to confirm the status of OTs contamination in marine sediments that were collected the seafood used (the same geographic area, 77 • 54 S, 36 • 63 W), the levels of total butyltin compounds ( OTs), TBT, di-(DBT) and monobutyltin (MBT) were found as 970.0, 398 ± 9.0, 276 ± 8.6 and 296 ± 2.0 ng Sn g −1 , (n = 3, OTs were determined for us by gas chromatography with pulsed flame photometric detection, Varian GC 3800, Walnut Creek, CA, USA) [35,59], respectively, suggesting the maintenance of OTs contamination in this environmental site. In addition, we estimated that each rat was exposed to the dose of the seafood intake rate of Brazilian riparian communities (i.e., 200 g/day/70 kg) based on previous literature of human health risk assessments [44,45]. Therefore, our dose is estimated to be within the range of human exposure (in Brazil) to seafood containing OTs.…”

Section: Experimental Animals and Treatmentsmentioning

confidence: 99%

“…Similarly, TBT doses were estimated to be 2.6 g TBT/day/person in Korean seafood [42,43]. Studies conducted in Brazil and Japan suggest the possibility of human health risks derived from the intake of OTs accumulated in seafood, especially in riparian populations [44,45]. The toxicology of OTs to humans is not fully understood [40,46].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Accumulation of organotins in seafood leads to reproductive tract abnormalities in female rats

Podratz

Merlo

Sena

et al. 2015

Reproductive Toxicology

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Section: Discussionmentioning

confidence: 99%

Section: Experimental Animals and Treatmentsmentioning

confidence: 99%

Section: Experimental Animals and Treatmentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Accumulation of organotins in seafood leads to reproductive tract abnormalities in female rats

Podratz

Merlo

Sena

et al. 2015

Reproductive Toxicology

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“…In addition, imposex has been reported in more than 190 marine species (2,8) and has been considered to be the most important endocrine disruption effect derived from a specific class of compounds (7). This syndrome is, therefore, a useful biomarker of organotin pollution (9)(10)(11). Besides affecting gastropods, organotins are also considered to be responsible for inducing hormonal alterations in bivalve www.bjournal.com.br Braz J Med Biol Res 44(9) 2011 mollusks (12), crustaceans (13) and fish (14).…”

mentioning

confidence: 99%

Triorganotin as a compound with potential reproductive toxicity in mammals

Filho

Lopes

Podratz

et al. 2011

Braz J Med Biol Res

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Organotin compounds are typical environmental contaminants and suspected endocrine-disrupting substances, which cause irreversible sexual abnormality in female mollusks, called "imposex". However, little is known about the capability of triorganotin compounds, such as tributyltin and triphenyltin, to cause disorders in the sexual development and reproductive functions of mammals, including humans and rodents. Moreover, these compounds can act as potential competitive inhibitors of aromatase enzyme and other steroidogenic enzymes, affecting the reproductive capacity of male and female mammals. In this review, we discuss the cellular, biochemical, and molecular mechanisms by which triorganotin compounds induce adverse effects in the mammalian reproductive function.

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Spatiotemporal appraisal of TBT contamination and imposex along a tropical bay (Todos os Santos Bay, Brazil)

Artifon

Castro

Fillmann

2016

Environ Sci Pollut Res

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A spatiotemporal evaluation of butyltin contamination was performed between 2010 and 2012 along Todos os Santos Bay (Northeast Brazil) using surface sediments, bivalve tissues (Anomalocardia brasiliana and Mytella guyanensis), and imposex occurrence (Stramonita rustica). The spatial study detected high tributyltin (TBT) levels (maximum values of 262 ng Sn g (-1) - 21,833 ng Sn g(-1) of total organic carbon - for surface sediments and 421 ng Sn g(-1) for bivalve tissues) in the innermost part of the bay. The TBT levels detected in M. guyanensis tissues might cause human health risk since local population consumes these organisms. These high concentrations observed in the bivalves might result in ingestions higher than the safe limits established by European Food Safety Authority (250 ng TBT kg(-1) day(-1)). Considering the temporal evaluation, no difference (p > 0.05) was observed between TBT concentrations in sediments obtained during the two sampling campaigns (2010/2011 and 2012). However, the increasing predominance of TBT metabolites (butyltin degradation index (BDI) >1) in more recent sediments indicates further degradation of old TBT inputs. In spite of that, recent inputs are still evident at this region. Nevertheless, a reduction of imposex parameters in S. rustica over the last decade suggests an overall decline in the TBT contamination, at least in the outermost and possible less impacted region of the bay. The TBT contamination is probably reducing due to the national and international legislative restrictions on the use of TBT as antifouling biocide. The contamination levels, however, are still relevant especially in the inner part of Todos os Santos Bay since they are above those that are likely to cause toxicity to the biota.

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Preliminary evaluation of human health risks from ingestion of organotin contamined seafood in Brazil

Cited by 13 publications

References 11 publications

Accumulation of organotins in seafood leads to reproductive tract abnormalities in female rats

Accumulation of organotins in seafood leads to reproductive tract abnormalities in female rats

Triorganotin as a compound with potential reproductive toxicity in mammals

Spatiotemporal appraisal of TBT contamination and imposex along a tropical bay (Todos os Santos Bay, Brazil)

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