Preliminary Evaluation of the Correlation Between in Vitro Release and in Vivo Bioavailability of Two Aminophylline Slow-Release Tablets

Lin, Shan‐Yang; Kao, Yuh-Horng; Chang, Hsiao-Ning

doi:10.1002/jps.2600790411

Cited by 22 publications

(7 citation statements)

References 15 publications

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“…It is freely soluble in water, and in the body readily liberates TP. Investigations concerning drug release characteristics of TP performed with commercially available AP sustained release products under various conditions (pH of the media, apparatus type, stirring rates) produced different results and conclusions (Herzfeldt et al, 1989;Lin et al, 1990). Differences in the TP release rates were obtained when drug release studies were conducted in different composition and pH value of dissolution media (Simons et al, 1984;Smart et al, 1992;Fassihi and Munday, 1989).…”

Section: Introductionmentioning

confidence: 96%

An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design

Petrović¹,

Ibrić

Trajkovic³

et al. 2009

Arch. Pharm. Res.

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The purpose of this study was to investigate the effect of various in vitro test conditions, on the release properties of theophylline (TP) from aminophylline (AP) matrices based on different hydroxypropylmethylcellulose (HPMC) ratio and viscosity grades. The general full factorial experimental design 3 x 3 x 3 was used, based on three independent variables: applied in vitro test (X1), HPMC/drug ratio (X2) and polymer viscosity grade (X3). The drug release percent at 2h (Y(2h)), 4h (Y(4h)) and 8 h (Y(8h)) and time for 50% of TP release from matrices (Y(T50%)) were response variables. Three in vitro tests were used: test 1 and test 4 (theophylline extended-release capsules, USP 30) and half-change method. According to factorial design analyses, in vitro test was the most significant factor influencing mechanism and amount of drug release. For half change method erosion was the predominant mechanism indicating case - II transport, while for test 1 the release mechanism were followed by both diffusion and erosion. The lowest release exponent n values, obtained from Ritger-Pepass equation, for test 4 indicate diffusion process inclining from Fickian diffusion to anomalous transport. Therefore, it is in the stage of development, useful to consider the influence of various in vitro test conditions on the formulation, in order to choose an optimal test for the purpose of future drug release examination.

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Section: Introductionmentioning

confidence: 96%

An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design

Petrović¹,

Ibrić

Trajkovic³

et al. 2009

Arch. Pharm. Res.

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show abstract

“…A partir de então, surgiram diversos trabalhos com o objetivo de estabelecer correlação entre os parâmetros da dissolução in vitro e os parâmetros relativos aos estudos de biodisponibilidade in vivo (correlações in vitro-in vivo ou correlações iviv) (Aoyagi et al, 1982;Avico et al, 1976;Bramanti, 1973;Dey et al, 1989;Drewe, Guitard, 1993;Grdinic et al, 1979;Hayashi et al, 1995;Lin et al, 1990;Yau, Meyer, 1983).…”

Section: Introductionunclassified

Avaliação biofarmacêutica in vitro de cápsulas de fluconazol

Porta¹,

Yamamichi²,

Storpirtis³

2002

Rev. Bras. Cienc. Farm.

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“…Polyvinyl alcohol and methyl acrylate copolymeric system (Sandeep et al 1992), a combination of hydrophilic and hydrophobi c matrix (Nath et al 2000) and a threelayer matrix technology (Yang and Faassihi 1996) have been 149 investigated for sustained release TPL formulations. A few researchers have successfully formulated sustained release tablets of some antibiotics by the matrix-embedding technique (Hilton and Deasy 1993;Lin et al 1990). Ethyl cellulose has been widely used for a number of water-soluble drugs to retard the release rate or to improve stability (Chowdary and Rao 1984;Bergisadi and Gurvardar 1989;Donbrow and Benita 1977;Nasa and Yadav 1989;Kasai and Koishi 1977).…”

mentioning

confidence: 99%

A Comparative Study of Controlled Release Matrix Tablets of Diclofenac Sodium, Ciprofloxacin Hydrochloride, and Theophylline

Saha

Sajeev²,

Sahoo³

2001

Drug Delivery

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The need for controlled release formulations for diclofenac sodium, ciprofloxacin, and theophylline is well recognized. In our study, controlled release tablets of the three drugs were formulated by the matrix-embedding technique using ethyl cellulose as retardant. Tablets of all the drugs were of good physical quality with respect to appearance, drug content uniformity, hardness, weight variation, and friability. In vitro release rate studies showed that ethyl cellulose extended the release of the three drugs to 12 hr or more. Release patterns from formulations of the three drugs followed Higuchi's square root kinetics. At pH 6.8, the release rate was higher in all three drugs, probably due to increased solubility of the drugs and/or increased swelling of ethyl cellulose at the higher pH. The formulations were highly stable and possessed reproducible release kinetics across batches.

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Preliminary Evaluation of the Correlation Between in Vitro Release and in Vivo Bioavailability of Two Aminophylline Slow-Release Tablets

Cited by 22 publications

References 15 publications

An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design

An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design

Avaliação biofarmacêutica in vitro de cápsulas de fluconazol

A Comparative Study of Controlled Release Matrix Tablets of Diclofenac Sodium, Ciprofloxacin Hydrochloride, and Theophylline

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